ACQUISITION OF THE INVEON SMALL ANIMAL PET/CT SYSTEM

收购 INVEON 小动物 PET/CT 系统

• 批准号: 7498345
• 负责人: RICHARD Andre LAFOREST
• 金额: $ 98.85万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498345
• 关键词: Animal Model; Animals; Basic Science; Cardiology; Clinical Research; Development; Diagnostic; Disease; Functional Imaging; Funding; Grant; Image; Immunology; Institutes; Lung; Mus; Neurology; Positron-Emission Tomography; Radiology Specialty; Rattus; Research Personnel; Research Project Grants; Science; Solutions; System; Translations; United States National Institutes of Health; Validation; cancer therapy; cardiogenesis; human disease; in vivo; instrumentation; multimodality; oncology; pet animal; pre-clinical; programs; public health relevance; whole body imaging

DESCRIPTION (provided by applicant): This proposal aims at acquiring funds from this High End Instrumentation Program for the acquisition of the small animal PET and CT combined camera, the Inveon from Siemens Pre- Clinical Solutions. This camera possesses a sensitivity of more than 10%, an extended field of view of 12cm allowing for imaging whole-body animals (mice and rats), and mostly, has inherent capability produce registered CT to PET images. Anatomical registration to functional image is now a prerequisite for the development of PET probes targeting the study of diseases using animal models in fields such as oncology, neurology, cardiology, immunology and pulmonary sciences. The Mallinckrodt Institute of Radiology is involved in numerous research projects, in the vast part supported by NIH grants, by the implication of a wide array of researchers. This camera will allow the developments of imaging agents for the study animal models of human diseases in vivo. Most of our applications are related to the developments of imaging agents for the diagnostics and therapy of cancer. PUBLIC HEALTH RELEVANCE: Multimodality imaging now represents the state of the heart for the development of imaging agents dedicated to the study of human diseases using animal models. Using animal models is important as it allow verification of hypothesis more quickly. It thus allow for faster validation of imaging agents for diagnostic and therapy and enables faster translation of basic research to clinical studies.

描述（由申请人提供）：本提案旨在从该高端仪器项目中获得资金，用于从Siemens Pre- Clinical Solutions购买小动物PET和CT组合摄像机Inveon。该相机具有超过10%的灵敏度，12 cm的扩展视场，允许对全身动物（小鼠和大鼠）进行成像，并且最重要的是，具有生成配准CT到PET图像的固有能力。功能图像的解剖配准现在是PET探针开发的先决条件，其目标是使用肿瘤学、神经学、心脏病学、免疫学和肺科学等领域的动物模型进行疾病研究。Mallinckrodt放射学研究所参与了许多研究项目，其中很大一部分由NIH赠款，由广泛的研究人员参与。该相机将允许开发用于体内人类疾病研究动物模型的成像剂。我们的大多数应用与癌症诊断和治疗的成像剂的开发有关。 公共卫生关系：多模态成像现在代表了心脏的状态，用于开发专用于使用动物模型研究人类疾病的成像剂。使用动物模型很重要，因为它可以更快地验证假设。因此，它允许更快地验证用于诊断和治疗的成像剂，并使基础研究更快地转化为临床研究。

项目成果

Gold nanocages as photothermal transducers for cancer treatment.

• DOI: 10.1002/smll.200902216
• 发表时间: 2010-04-09
• 期刊: SMALL
• 影响因子: 13.3
• 作者: Chen, Jingyi;Glaus, Charles;Laforest, Richard;Zhang, Qiang;Yang, Miaoxian;Gidding, Michael;Welch, Michael J.;Xia, Younan
• 通讯作者: Xia, Younan

Effect of α-Methyl versus α-Hydrogen Substitution on Brain Availability and Tumor Imaging Properties of Heptanoic [F-18]Fluoroalkyl Amino Acids for Positron Emission Tomography (PET).

• DOI: 10.1021/acs.jmedchem.6b00189
• 发表时间: 2016-04-14
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Bouhlel A;Alyami W;Li A;Yuan L;Rich K;McConathy J
• 通讯作者: McConathy J

Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[(76)Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging.

• DOI: 10.1021/acs.jmedchem.5b01035
• 发表时间: 2015-11-12
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Bartels JL;Huang C;Li A;Yuan L;Rich K;McConathy J;Lapi SE
• 通讯作者: Lapi SE