Research Core
Research Core
批准号:
10176493
负责人:
HEATHER M STAPLETON
金额:
$25.77万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-10 至 2024-05-31
关键词:
AirBiologyChemicalsCommunitiesComplex MixturesConsultationsCore FacilityDataDatabasesDevelopmentDoctor of PhilosophyDustElementsEnsureEnvironmental ExposureEnvironmental HealthEnvironmental ImpactEnvironmental PollutionEpidemiologistExperimental DesignsExposure toFlame RetardantsHealthHumanInfrastructureLaboratoriesMass Spectrum AnalysisMeasurementMeasuresMetalsMethodologyMethodsOrganic ChemicalsPesticidesPlasticizersPositioning AttributePreparationProtocols documentationQuality ControlResearchResearch PersonnelResolutionResourcesSamplingScientistServicesSiliconesSoilStructureSuperfundTechnical ExpertiseTechnologyTimeTrace ElementsTrace metalUnited States National Institutes of HealthUniversitiesVisionWaterWorkdata centersdata harmonizationexperienceexposed human populationimprovedinstrumentationmembernovelorganic contaminantphthalatesprogramsquality assurancesample collectionscreening
中文摘要
项目摘要
杜克环境分析实验室(DEAL)中心的目的是提供一套全面的
分析服务,以支持流行病学家和卫生研究人员进行研究,重点是
环境污染物暴露对人类健康的影响。环境样品分析
资源(ESAR)核心的交易中心将有助于实现这一愿景,提供分析服务,
从不同的样品介质中分析有机化学品和无机元素。ESAR将利用切割-
利用高灵敏度的化学品进行可疑筛选和非靶向分析的边缘技术和方法,
分辨率质谱仪,并将采样分为三个不同的实验室:目标有机,
目标无机物和非目标有机物。所有三个实验室都将提供咨询,
向HHEAR网络研究人员提供有关实验设计、暴露评估、样本收集和
处理,由DEAL行政核心的项目管理专业知识协调工作。的
目标有机污染物分析实验室(由石楠斯台普顿博士指导)将提供以下服务:
有机污染物的样品制备、提取和定量分析(例如,阻燃剂,
聚氟烷基物质、邻苯二甲酸酯、增塑剂等)不同的环境媒介。目标
无机分析实验室(由Heileen Hsu-Kim博士领导)将提供相同的微量元素服务
(e.g.,金属),重点是物种形成和生物可及性。最后,非目标高分辨率质量
光谱实验室将提供高分辨率,准确的质谱服务,用于
开发生物学方法和方法,以帮助衡量人类的总体情况,
暴露于化学品(这项工作将由李弗格森博士指导)。ESAR的独特结构将
允许联合主任在他们自己的实验室中利用他们的相关专业知识,同时也进行协作和共享
信息,以实现ESAR的总体目标。此外,ESAR联合主任将
与开发核心双向协作,提高提取效率
方法,在靶向和非靶向方法工作流程中建立一致性,并扩展
目标有机污染物分析实验室,因为新出现的污染物被确定。
英文摘要
PROJECT ABSTRACT
The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of
analytical services to support epidemiologists and health researchers conducting studies focusing on the
impact of environmental contaminant exposures on human health. The Environmental Sample Analysis
Resource (ESAR) Core of the DEAL Hub will help achieve this vision by providing analytical services for the
analysis of organic chemicals and inorganic elements from diverse sample media. ESAR will utilize cutting-
edge technology and approaches for suspect-screening and non-targeted analyses of chemicals using high-
resolution mass spectrometry and will separate sampling into three distinct laboratories: Targeted Organic,
Targeted Inorganic, and Untargeted Organic. All three of the laboratories will provide consultation and
advice to HHEAR Network researchers on experimental design, exposure assessment, sample collection, and
processing, efforts coordinated by the project management expertise of the DEAL Administrative Core. The
Targeted Organic Contaminant Analysis Lab (directed by Dr. Heather Stapleton) will provide services for
sample preparation, extraction and quantitative analysis of organic contaminants (e.g., flame retardants,
polyflouroalkyl substances, phthalates, plasticizers, etc.) in diverse environmental media. The Targeted
Inorganic Analysis Lab (directed by Dr. Heileen Hsu-Kim) will provide the same services for trace elements
(e.g., metal) with a focus on speciation and bioaccessibility. Finally, the Non-Targeted High Resolution Mass
Spectrometry Lab will provide high-resolution, accurate-mass mass spectrometry services for use in
developing exposomics approaches and methodologies in order to help measure the totality of human
exposure to chemicals (this effort will be directed by Dr. Lee Ferguson). The unique structure of the ESAR will
allow the Co-Directors to utilize their relevant expertise in their own labs, while also collaborating and sharing
information in order to achieve the overarching aims of the ESAR. In addition, the ESAR Co-directors will work
collaboratively and bi-directionally with the Developmental Core to improve the efficiency of extraction
methods, build consistency in the targeted and non-targeted method workflows, and expand the analyte list of
the Targeted Organic Contaminant Analysis Lab as new emerging contaminants are identified.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Flame retardant effects on thyroid hormone regulation at the fetal-maternal interface of the placenta
-
批准号:10609446
-
项目类别:
-
资助金额:$59.21万
-
财政年份:2020
-
负责人:HEATHER M STAPLETON
-
依托单位:
Admin Core
-
批准号:10646273
-
项目类别:
-
资助金额:$39.78万
-
财政年份:2019
-
负责人:HEATHER M STAPLETON
-
依托单位:
Admin Core
-
批准号:10430118
-
项目类别:
-
资助金额:$39.18万
-
财政年份:2019
-
负责人:HEATHER M STAPLETON
-
依托单位:
Research Core
-
批准号:10646279
-
项目类别:
-
资助金额:$62.6万
-
财政年份:2019
-
负责人:HEATHER M STAPLETON
-
依托单位:
Research Core
-
批准号:10430120
-
项目类别:
-
资助金额:$63.54万
-
财政年份:2019
-
负责人:HEATHER M STAPLETON
-
依托单位:
Admin Core
-
批准号:10176491
-
项目类别:
-
资助金额:$15.45万
-
财政年份:2019
-
负责人:HEATHER M STAPLETON
-
依托单位:
Deiodinase Activity as a Biomarker of Response to Brominated Flame Retardants
-
批准号:8179666
-
项目类别:
-
资助金额:$34.55万
-
财政年份:2011
-
负责人:HEATHER M STAPLETON
-
依托单位:
Deiodinase Activity as a Biomarker of Response to Brominated Flame Retardants
-
批准号:8313850
-
项目类别:
-
资助金额:$38.74万
-
财政年份:2011
-
负责人:HEATHER M STAPLETON
-
依托单位:
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
-
批准号:8291305
-
项目类别:
-
资助金额:$36.83万
-
财政年份:2008
-
负责人:HEATHER M STAPLETON
-
依托单位:
Children Exposure to SVOC Mixtures Indoors and Associations with Obesity
-
批准号:8761391
-
项目类别:
-
资助金额:$59.54万
-
财政年份:2008
-
负责人:HEATHER M STAPLETON
-
依托单位:
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
-
批准号:7540236
-
项目类别:
-
资助金额:$52.99万
-
财政年份:2008
-
负责人:HEATHER M STAPLETON
-
依托单位:
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
-
批准号:7674010
-
项目类别:
-
资助金额:$48.97万
-
财政年份:2008
-
负责人:HEATHER M STAPLETON
-
依托单位:
Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
-
批准号:8092541
-
项目类别:
-
资助金额:$37.09万
-
财政年份:2008
-
负责人:HEATHER M STAPLETON
-
依托单位:
Project 1: Prenatal Exposures to PAHs and Metals in an Impacted Community: Assessing Neurodevelopment Impacts and Tracing Metal Sources
-
批准号:10698009
-
项目类别:
-
资助金额:$30.18万
-
财政年份:2000
-
负责人:HEATHER M STAPLETON
-
依托单位:
Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation
-
批准号:10819905
-
项目类别:
-
资助金额:$4.99万
-
财政年份:2000
-
负责人:HEATHER M STAPLETON
-
依托单位:
Administrative and Research Translation Core (ARTC)
-
批准号:10353156
-
项目类别:
-
资助金额:$18.95万
-
财政年份:2000
-
负责人:HEATHER M STAPLETON
-
依托单位:
Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation
-
批准号:10353150
-
项目类别:
-
资助金额:$233.93万
-
财政年份:2000
-
负责人:HEATHER M STAPLETON
-
依托单位:
Project 1: Prenatal Exposures to PAHs and Metals in an Impacted Community: Assessing Neurodevelopment Impacts and Tracing Metal Sources
-
批准号:10353151
-
项目类别:
-
资助金额:$31.37万
-
财政年份:2000
-
负责人:HEATHER M STAPLETON
-
依托单位:
Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation
-
批准号:10698008
-
项目类别:
-
资助金额:$233.71万
-
财政年份:2000
-
负责人:HEATHER M STAPLETON
-
依托单位:
Administrative and Research Translation Core (ARTC)
-
批准号:10698043
-
项目类别:
-
资助金额:$19.83万
-
财政年份:2000
-
负责人:HEATHER M STAPLETON
-
依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
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批准号:31024801
-
项目类别:专项基金项目
-
资助金额:24.0万元
-
批准年份:2010
-
负责人:贺萍
-
依托单位: