Research Core

项目摘要 杜克环境分析实验室(Deal)中心的目的是提供一套全面的 提供分析服务，以支持流行病学家和卫生研究人员进行侧重于 环境污染物暴露对人体健康的影响。环境样品分析 资源(Esar)交易中心的核心将通过提供以下分析服务来帮助实现这一愿景 不同样品介质中有机化学品和无机元素的分析。ESAR将利用切割- EDGE技术和方法，用于对化学品进行可疑筛选和非靶标分析，使用高密度的 并将把样品分到三个不同的实验室：靶向有机， 有针对性的无机和无针对性的有机。这三个实验室都将提供咨询和 向HHEAR网络研究人员提供关于实验设计、暴露评估、样本收集和 处理，由交易管理核心的项目管理专业知识协调的工作。这个 目标有机污染物分析实验室(由Heather Stapleton博士指导)将为 有机污染物(例如，阻燃剂， 聚氟烷基物质、邻苯二甲酸酯、增塑剂等)在不同的环境媒体上。目标人群 无机分析实验室(由海琳·徐金博士指导)将为微量元素提供同样的服务 (例如，金属)，重点是物种形成和生物可获得性。最后，非靶向高分辨率质量 光谱实验室将提供高分辨率、准确的质谱学服务，用于 发展暴露组学的途径和方法，以帮助测量人类的总体 接触化学物质(这项工作将由Lee Ferguson博士指导)。ESAR遗嘱的独特结构 允许联席主任在自己的实验室中利用他们的相关专业知识，同时也进行协作和分享 信息，以实现ESAR的总体目标。此外，ESAR联席董事将发挥作用 与开发核心合作双向提高提取效率 方法，在目标方法和非目标方法工作流程中建立一致性，并扩展分析物列表 目标有机污染物分析实验室被确定为新出现的污染物。

PROJECT ABSTRACT The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of analytical services to support epidemiologists and health researchers conducting studies focusing on the impact of environmental contaminant exposures on human health. The Environmental Sample Analysis Resource (ESAR) Core of the DEAL Hub will help achieve this vision by providing analytical services for the analysis of organic chemicals and inorganic elements from diverse sample media. ESAR will utilize cutting- edge technology and approaches for suspect-screening and non-targeted analyses of chemicals using high- resolution mass spectrometry and will separate sampling into three distinct laboratories: Targeted Organic, Targeted Inorganic, and Untargeted Organic. All three of the laboratories will provide consultation and advice to HHEAR Network researchers on experimental design, exposure assessment, sample collection, and processing, efforts coordinated by the project management expertise of the DEAL Administrative Core. The Targeted Organic Contaminant Analysis Lab (directed by Dr. Heather Stapleton) will provide services for sample preparation, extraction and quantitative analysis of organic contaminants (e.g., flame retardants, polyflouroalkyl substances, phthalates, plasticizers, etc.) in diverse environmental media. The Targeted Inorganic Analysis Lab (directed by Dr. Heileen Hsu-Kim) will provide the same services for trace elements (e.g., metal) with a focus on speciation and bioaccessibility. Finally, the Non-Targeted High Resolution Mass Spectrometry Lab will provide high-resolution, accurate-mass mass spectrometry services for use in developing exposomics approaches and methodologies in order to help measure the totality of human exposure to chemicals (this effort will be directed by Dr. Lee Ferguson). The unique structure of the ESAR will allow the Co-Directors to utilize their relevant expertise in their own labs, while also collaborating and sharing information in order to achieve the overarching aims of the ESAR. In addition, the ESAR Co-directors will work collaboratively and bi-directionally with the Developmental Core to improve the efficiency of extraction methods, build consistency in the targeted and non-targeted method workflows, and expand the analyte list of the Targeted Organic Contaminant Analysis Lab as new emerging contaminants are identified.