University of Virginia - icddr,b Research Unit for Women's and Children's Health Research

项目摘要 我们建议弗吉尼亚大学（UVa）和icddr，B成为全球范围内的研究单位（RU）。 妇女和儿童健康研究网络。 重要性：孟加拉国和其他中低收入国家的母亲和儿童遭受的痛苦不成比例 产妇和婴儿营养不良、腹泻和呼吸道感染造成的新生儿死亡率、疫苗 失败和儿童发育受损。UVA-icddrb研究单位（RU）将满足这些关键需求 通过增加科学专门知识来补充现有网络的优势， 在传染病，神经认知发育，人类遗传学，母胎医学，免疫学， 疫苗学RU还将为农村和城市人口提供特殊的临床试验机会。 研究者：RU主要研究者（PI）William Petri和高级外国研究者（SFI）Rashidul Haque在25年的时间里共同领导多学科团队研究母婴，共同出版了100多篇论文。 以及8项正在进行的临床试验或观察性研究。在icddr，B，一个多学科小组加入了他们 荷兰盾Qadri（免疫学），K. Zaman（Vaccinology），F. Tofail（儿童发展），M。Billah和S.埃尔阿里芬 （妇幼保健），T。艾哈迈德（婴儿营养）和UVa的C。奇泽姆（ob/gyn）和R.辛金 （生物学）。 创新：RU在母婴健康方面有着悠久的创新研究和专业知识历史，包括 感染和炎症对儿童神经认知发育的影响，空气中污染物对 呼吸道感染、口服疫苗失败时肠道功能受损和营养不良。 方法：RU将在网络内开展工作，促进有可能导致 通过RU与以下机构的伙伴关系，可持续地改善孕产妇和儿童健康： 孟加拉国政府（表现为在全世界实施口服体液补充溶液， 在icddr，B发现，并在全国范围内采用社区护理的Matlab模型）。 环境：RU拥有无与伦比的多学科实力，实验室设施和城市环境。 和农村人口的母亲和儿童。icddr，B是世界上最重要的全球卫生机构之一， 发展中国家有200多个正在进行的临床试验/方案。UVa传染病部 和国际卫生是弗吉尼亚大学最大的研究单位，每年获得超过2000万美元的赠款支持， 超过二十多个临床协议四分之一的世纪UVA-icdddb合作和独特的， 互补的专业知识有望为网络的目标带来无与伦比的优势， 可持续地改善妇幼保健。

Project Summary We propose that the University of Virginia (UVa) and icddr,b become a Research Unit (RU) within the Global Network for Women's and Children's Health Research. Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, vaccine failure and impaired child development. The UVa-icddrb Research Unit (RU) will address these critical needs of women and young children by complementing the existing Network strengths with added scientific expertise in infectious diseases, neurocognitive development, human genetics, maternal-fetal medicine, immunology, and vaccinology. The RU will also provide extraordinary access to rural and urban populations for clinical trials. Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul Haque have for 25 years co-led multidisciplinary teams studying maternal-child, with over 100 co-publications and eight on-going clinical trials or observational studies. They are joined at icddr,b by a multidisciplinary team of F. Qadri (Immunology), K. Zaman (Vaccinology), F. Tofail (Child Development), M. Billah and S. El Arifeen (Maternal and Child Health), T. Ahmed (infant nutrition) and at UVa by C. Chisholm (ob/gyn) and R. Sinkin (neonatology). Innovation: The RU has a long history of innovative studies and expertise in maternal-child health, including the impact of infection and inflammation on child neurocognitive development, role of airborne pollutants on respiratory infection, function of gut damage in oral vaccine failure and malnutrition. Approach: The RU will work within the Network to promote innovative studies that have the potential to lead to actionable and sustainable improvement in maternal and child health through the partnership of the RU with the government of Bangladesh (manifest through the worldwide implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide of the Matlab model of community based care). Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases and International Health is the largest research unit at UVa with over $20 million in annual grant support and over two dozen active clinical protocols. The quarter of a century UVa-icddrb collaboration and unique and complementary expertise promises to bring unparalleled strengths to the Network's goal of making sustainable improvements in maternal and child health.