University of Virginia - icddr,b Research Unit for Women's and Children's Health Research

项目摘要 我们建议弗吉尼亚大学(UVA)和ICDDR，b成为全球 妇女和儿童健康研究网络。 意义：孟加拉国和其他中低收入国家的母亲和儿童遭受不成比例的痛苦 从母婴营养不良、新生儿腹泻和呼吸道感染死亡率、疫苗 失败和损害儿童发展。UVA-ICDDRB研究单位(RU)将满足这些关键需求 通过增加科学专门知识来补充现有的网络优势，从而保护妇女和儿童的健康 传染病、神经认知发育、人类遗传学、母婴医学、免疫学、 和疫苗学。RU还将为农村和城市人口提供非同寻常的临床试验机会。 调查人员：RU首席调查员(PI)William Petri和高级外国调查员(SFI)Rashidul 哈克25年来一直共同领导研究母婴的多学科团队，发表了100多份联合出版物 以及八项正在进行的临床试验或观察性研究。他们在ICDDR，b由一个多学科小组加入。 F·卡德里(免疫学)、K·扎曼(疫苗学)、F·托费尔(儿童发育)、M.Billah和S.El Arifeen (孕产妇和儿童健康)，T.Ahmed(婴儿营养)，以及C.Chisholm(ob/gyn)和R.Sinkin在UVA (新生儿学)。 创新：北卡罗来纳大学在母婴健康方面的创新研究和专业知识有很长的历史，包括 感染和炎症对儿童神经认知发育的影响，空气污染物对儿童神经认知发育的影响 呼吸道感染，口服疫苗失败和营养不良时的肠道损伤功能。 方法：研究组将在网络内工作，促进有潜力导致 通过合作伙伴关系，切实和可持续地改善妇幼保健 孟加拉国政府(通过在全球范围内实施口服补液解决方案， 在ICDDR，b发现，并在全国范围内采用基于社区的护理的MatLab模式)。 环境：RU拥有无与伦比的多学科实力、实验室设施和进入城市的通道 以及农村人口的母亲和儿童。ICDDR，b是全球最重要的卫生机构之一 发展中国家拥有200多项正在进行的临床试验/方案。弗吉尼亚大学传染病学部 国际健康是弗吉尼亚大学最大的研究单位，每年提供超过2000万美元的赠款支持和 超过24个有效的临床方案。四分之一个世纪UVA-ICDDRB的合作和独特的 互补的专业知识有望为网络的目标带来无与伦比的优势 可持续改善孕产妇和儿童健康。

Project Summary We propose that the University of Virginia (UVa) and icddr,b become a Research Unit (RU) within the Global Network for Women's and Children's Health Research. Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, vaccine failure and impaired child development. The UVa-icddrb Research Unit (RU) will address these critical needs of women and young children by complementing the existing Network strengths with added scientific expertise in infectious diseases, neurocognitive development, human genetics, maternal-fetal medicine, immunology, and vaccinology. The RU will also provide extraordinary access to rural and urban populations for clinical trials. Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul Haque have for 25 years co-led multidisciplinary teams studying maternal-child, with over 100 co-publications and eight on-going clinical trials or observational studies. They are joined at icddr,b by a multidisciplinary team of F. Qadri (Immunology), K. Zaman (Vaccinology), F. Tofail (Child Development), M. Billah and S. El Arifeen (Maternal and Child Health), T. Ahmed (infant nutrition) and at UVa by C. Chisholm (ob/gyn) and R. Sinkin (neonatology). Innovation: The RU has a long history of innovative studies and expertise in maternal-child health, including the impact of infection and inflammation on child neurocognitive development, role of airborne pollutants on respiratory infection, function of gut damage in oral vaccine failure and malnutrition. Approach: The RU will work within the Network to promote innovative studies that have the potential to lead to actionable and sustainable improvement in maternal and child health through the partnership of the RU with the government of Bangladesh (manifest through the worldwide implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide of the Matlab model of community based care). Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases and International Health is the largest research unit at UVa with over $20 million in annual grant support and over two dozen active clinical protocols. The quarter of a century UVa-icddrb collaboration and unique and complementary expertise promises to bring unparalleled strengths to the Network's goal of making sustainable improvements in maternal and child health.