University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
基本信息
- 批准号:10176548
- 负责人:
- 金额:$ 65.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptionAfricanAsiansBangladeshBirth WeightCessation of lifeChildChild DevelopmentChild HealthChronicClinicalClinical ProtocolsClinical ResearchClinical TrialsClinical trial protocol documentCollaborationsCommunicable DiseasesCommunitiesComplementCoordination and CollaborationCountryDataDevelopmentDevelopmental Delay DisordersDiarrheaEnteralEnvironmentFacility AccessesFailureFunctional disorderGoalsGovernmentGrantHealthHealth StatusHuman GeneticsImmunologyImpairmentIncomeInfant MalnutritionInfectionInflammationInstitutesInternationalInterventionKnowledgeLeadLeadershipLive BirthMalnutritionMaternal MortalityMaternal and Child HealthMaternal-fetal medicineModelingMothersMucous MembraneNeonatal MortalityNeonatologyNeurocognitiveObservational StudyOralParasitologyPositioning AttributePregnancyPregnant WomenPrincipal InvestigatorPublic HealthPublicationsRecording of previous eventsRehydration SolutionsResearchResearch Peer ReviewResearch PersonnelRespiratory Tract InfectionsRoleRotavirus VaccinesRuralRural PopulationScientistSiteSustainable DevelopmentTestingUnited NationsUniversitiesUrban PopulationVaccinesVirginiaWeight GainWomanWorkauthoritybasecommunity based caredietary supplementsexperienceglobal healthimprovedinfant nutritioninnovationinventionlaboratory facilitymicrobiomemolecular diagnosticsmortalitymultidisciplinaryneonatal healthneurodevelopmentnovelnutritionoral vaccinepollutantpopulation healthpreventvaccinology
项目摘要
Project Summary
We propose that the University of Virginia (UVa) and icddr,b become a Research Unit (RU) within the Global
Network for Women's and Children's Health Research.
Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately
from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, vaccine
failure and impaired child development. The UVa-icddrb Research Unit (RU) will address these critical needs
of women and young children by complementing the existing Network strengths with added scientific expertise
in infectious diseases, neurocognitive development, human genetics, maternal-fetal medicine, immunology,
and vaccinology. The RU will also provide extraordinary access to rural and urban populations for clinical trials.
Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul
Haque have for 25 years co-led multidisciplinary teams studying maternal-child, with over 100 co-publications
and eight on-going clinical trials or observational studies. They are joined at icddr,b by a multidisciplinary team
of F. Qadri (Immunology), K. Zaman (Vaccinology), F. Tofail (Child Development), M. Billah and S. El Arifeen
(Maternal and Child Health), T. Ahmed (infant nutrition) and at UVa by C. Chisholm (ob/gyn) and R. Sinkin
(neonatology).
Innovation: The RU has a long history of innovative studies and expertise in maternal-child health, including
the impact of infection and inflammation on child neurocognitive development, role of airborne pollutants on
respiratory infection, function of gut damage in oral vaccine failure and malnutrition.
Approach: The RU will work within the Network to promote innovative studies that have the potential to lead to
actionable and sustainable improvement in maternal and child health through the partnership of the RU with
the government of Bangladesh (manifest through the worldwide implementation of oral rehydration solution,
discovered at icddr,b and adoption nationwide of the Matlab model of community based care).
Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban
and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in
the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases
and International Health is the largest research unit at UVa with over $20 million in annual grant support and
over two dozen active clinical protocols. The quarter of a century UVa-icddrb collaboration and unique and
complementary expertise promises to bring unparalleled strengths to the Network's goal of making
sustainable improvements in maternal and child health.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William A Petri其他文献
Environmental enteropathy and malnutrition: do we know enough to intervene?
- DOI:
10.1186/s12916-014-0187-1 - 发表时间:
2014-10-14 - 期刊:
- 影响因子:8.300
- 作者:
William A Petri;Caitlin Naylor;Rashidul Haque - 通讯作者:
Rashidul Haque
The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction
环境肠道功能障碍活检倡议(EEDBI)联盟:环境肠道功能障碍的黏膜研究
- DOI:
10.1016/j.ajcnut.2024.02.003 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Donna M Denno;Sheraz Ahmed;Tahmeed Ahmed;S Asad Ali;Beatrice Amadi;Paul Kelly;Sarah Lawrence;Mustafa Mahfuz;Chelsea Marie;Sean R Moore;James P Nataro;William A Petri;Peter B Sullivan;Phillip I Tarr;Kumail Ahmed;Md Ashraful Alam;Barrett H Barnes;SM Khodeza Nahar Begum;Stephen M Borowitz;Kanta Chandwe;Fayaz Umrani - 通讯作者:
Fayaz Umrani
Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
孟加拉国、巴基斯坦和赞比亚营养不良儿童队列研究与美国儿童相比的环境性肠功能障碍的组织病理学基础
- DOI:
10.1016/j.ajcnut.2024.02.028 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Paul Kelly;Kelley VanBuskirk;David Coomes;Samer Mouksassi;Gerald Smith;Zehra Jamil;Md Shabab Hossain;Sana Syed;Chelsea Marie;Phillip I Tarr;Peter B Sullivan;William A Petri;Donna M Denno;Tahmeed Ahmed;Mustafa Mahfuz;S Asad Ali;Sean R Moore;I Malick Ndao;Guillermo J Tearney;Ömer H Yilmaz;Kanekwa Zyambo - 通讯作者:
Kanekwa Zyambo
Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction
环境性肠功能障碍中小肠炎症和上皮参数的多重免疫组化评估
- DOI:
10.1016/j.ajcnut.2024.02.033 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Kelley VanBuskirk;Monica Mweetwa;Tad Kolterman;Shyam Raghavan;Tahmeed Ahmed;S Asad Ali;SM Khodeza Nahar Begum;Ellen Besa;Donna M Denno;Zehra Jamil;Paul Kelly;Mustafa Mahfuz;Sean R Moore;Samer Mouksassi;William A Petri;Phillip I Tarr;Peter B Sullivan;Christopher A Moskaluk;Kumail Ahmed;Sheraz Ahmed;Omer H Yilmaz - 通讯作者:
Omer H Yilmaz
Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers
十二指肠转录组学显示了全球多个中心环境肠道功能障碍儿童组织炎症和免疫细胞浸润的特征
- DOI:
10.1016/j.ajcnut.2024.02.023 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Chelsea Marie;Subhasish Das;David Coomes;Tahmeed Ahmed;S Asad Ali;Junaid Iqbal;Paul Kelly;Mustafa Mahfuz;Sean R Moore;William A Petri;Phillip I Tarr;Lee A Denson;Kumail Ahmed;Sheraz Ahmed;Md Ashraful Alam;David Auble;SM Khodeza Nahar Begum;Ellen Besa;Mubanga Chama;Donna M Denno;Kanekwa Zyambo - 通讯作者:
Kanekwa Zyambo
William A Petri的其他文献
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{{ truncateString('William A Petri', 18)}}的其他基金
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
- 批准号:
10223165 - 财政年份:2020
- 资助金额:
$ 65.17万 - 项目类别:
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
- 批准号:
10653065 - 财政年份:2020
- 资助金额:
$ 65.17万 - 项目类别:
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
- 批准号:
10443698 - 财政年份:2020
- 资助金额:
$ 65.17万 - 项目类别:
NICHD Global Network for Women’s and Children’s Health Research: Research Units
NICHD 全球妇女和儿童健康研究网络:研究单位
- 批准号:
10746195 - 财政年份:2018
- 资助金额:
$ 65.17万 - 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
- 批准号:
9754231 - 财政年份:2018
- 资助金额:
$ 65.17万 - 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
- 批准号:
10413887 - 财政年份:2018
- 资助金额:
$ 65.17万 - 项目类别:
Role of Type 2 Immunity in Innate Protection from C. difficile
2 型免疫在艰难梭菌先天保护中的作用
- 批准号:
10467414 - 财政年份:2016
- 资助金额:
$ 65.17万 - 项目类别:
Role of Type 2 Immunity in Innate Protection from C. difficile
2 型免疫在艰难梭菌先天保护中的作用
- 批准号:
10561651 - 财政年份:2016
- 资助金额:
$ 65.17万 - 项目类别:
Role of IL-23 in the Immunopathogenesis of C. difficile colitis
IL-23 在艰难梭菌结肠炎免疫发病机制中的作用
- 批准号:
9057951 - 财政年份:2015
- 资助金额:
$ 65.17万 - 项目类别:
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