NICHD Global Network for Women’s and Children’s Health Research: Research Units

NICHD 全球妇女和儿童健康研究网络:研究单位

基本信息

  • 批准号:
    10746195
  • 负责人:
  • 金额:
    $ 53.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-08-10 至 2030-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, and maternal mortality from childbirth, vaccine failure and impaired child development. The UVA-icddrb Research Unit (RU) addresses critical needs of women and young children by bringing to the Network strengths in infectious diseases, lactation, pharmacology, neurocognitive development, human genetics, maternal-fetal medicine, immunology, vaccinology and CTSA coordination. The RU has access to nearly 8000 pregnant women annually at our existing clinical trial sites, is highly attuned to ethical and cultural issues with local community and ethical review boards, and leads Network studies of COVID-19 in pregnancy and maternal anemia. Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul Haque have for 30 years co-led multidisciplinary teams studying maternal-child health, with over 170 co- publications and ten on-going or completed clinical studies in the last five years. They are joined at icddr,b and UVA by a diverse and multidisciplinary core team of 19 accomplished investigators in maternal-child health. Innovation: The RU conceptualized the multi-site study of COVID-19 infection during pregnancy that demonstrated minimal impact on birth outcomes, is leading a study of the role of maternal anemia on low-birth weight infants, has multi-site Network-approved protocols on maternal nutritional supplements and on asymptomatic bacteriuria and has pioneered electronic data capture for the Network. Special capabilities include infectious diseases, pharmacology, lactation, and novel clinical trial designs through the CTSA. Approach: The RU has conducted 12 clinical trials since 2016 with 99% adherence to follow-up visits, and access to 8000 pregnant women annually in existing clinical trial sites. Science to policy translation catalyzed by the partnership of the icddr,b with the Government of Bangladesh, as evidenced by the worldwide implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide, and the Matlab model of community -based care. Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases and International Health has a unique focus on Global Health, with over $16 million in annual grant support and over two dozen active clinical protocols. UVa-icddrb unique and complementary expertise will continue to bring unparalleled strengths to the Network’s goal of making sustainable improvements in maternal and child health.
项目总结

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study.
孟加拉国农村地区早产期的全身性炎症,肠病大肠杆菌和微量营养素不足,可能是早产的预测指标:一项前瞻性研究。
Setting up a maternal and newborn registry applying electronic platform: an experience from the Bangladesh site of the global network for women's and children's health.
  • DOI:
    10.1186/s12978-020-00993-w
  • 发表时间:
    2020-11-30
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Billah SM;Haque R;Chowdhury AI;Siraj MS;Rahman QS;Hossain T;Alam A;Alam M;Marie C;McGrath B;El Arifeen S;Petri WA Jr
  • 通讯作者:
    Petri WA Jr
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William A Petri其他文献

Environmental enteropathy and malnutrition: do we know enough to intervene?
  • DOI:
    10.1186/s12916-014-0187-1
  • 发表时间:
    2014-10-14
  • 期刊:
  • 影响因子:
    8.300
  • 作者:
    William A Petri;Caitlin Naylor;Rashidul Haque
  • 通讯作者:
    Rashidul Haque
The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction
环境肠道功能障碍活检倡议(EEDBI)联盟:环境肠道功能障碍的黏膜研究
  • DOI:
    10.1016/j.ajcnut.2024.02.003
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Donna M Denno;Sheraz Ahmed;Tahmeed Ahmed;S Asad Ali;Beatrice Amadi;Paul Kelly;Sarah Lawrence;Mustafa Mahfuz;Chelsea Marie;Sean R Moore;James P Nataro;William A Petri;Peter B Sullivan;Phillip I Tarr;Kumail Ahmed;Md Ashraful Alam;Barrett H Barnes;SM Khodeza Nahar Begum;Stephen M Borowitz;Kanta Chandwe;Fayaz Umrani
  • 通讯作者:
    Fayaz Umrani
Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
孟加拉国、巴基斯坦和赞比亚营养不良儿童队列研究与美国儿童相比的环境性肠功能障碍的组织病理学基础
  • DOI:
    10.1016/j.ajcnut.2024.02.028
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Paul Kelly;Kelley VanBuskirk;David Coomes;Samer Mouksassi;Gerald Smith;Zehra Jamil;Md Shabab Hossain;Sana Syed;Chelsea Marie;Phillip I Tarr;Peter B Sullivan;William A Petri;Donna M Denno;Tahmeed Ahmed;Mustafa Mahfuz;S Asad Ali;Sean R Moore;I Malick Ndao;Guillermo J Tearney;Ömer H Yilmaz;Kanekwa Zyambo
  • 通讯作者:
    Kanekwa Zyambo
Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction
环境性肠功能障碍中小肠炎症和上皮参数的多重免疫组化评估
  • DOI:
    10.1016/j.ajcnut.2024.02.033
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Kelley VanBuskirk;Monica Mweetwa;Tad Kolterman;Shyam Raghavan;Tahmeed Ahmed;S Asad Ali;SM Khodeza Nahar Begum;Ellen Besa;Donna M Denno;Zehra Jamil;Paul Kelly;Mustafa Mahfuz;Sean R Moore;Samer Mouksassi;William A Petri;Phillip I Tarr;Peter B Sullivan;Christopher A Moskaluk;Kumail Ahmed;Sheraz Ahmed;Omer H Yilmaz
  • 通讯作者:
    Omer H Yilmaz
Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers
十二指肠转录组学显示了全球多个中心环境肠道功能障碍儿童组织炎症和免疫细胞浸润的特征
  • DOI:
    10.1016/j.ajcnut.2024.02.023
  • 发表时间:
    2024-09-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Chelsea Marie;Subhasish Das;David Coomes;Tahmeed Ahmed;S Asad Ali;Junaid Iqbal;Paul Kelly;Mustafa Mahfuz;Sean R Moore;William A Petri;Phillip I Tarr;Lee A Denson;Kumail Ahmed;Sheraz Ahmed;Md Ashraful Alam;David Auble;SM Khodeza Nahar Begum;Ellen Besa;Mubanga Chama;Donna M Denno;Kanekwa Zyambo
  • 通讯作者:
    Kanekwa Zyambo

William A Petri的其他文献

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{{ truncateString('William A Petri', 18)}}的其他基金

Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
  • 批准号:
    10223165
  • 财政年份:
    2020
  • 资助金额:
    $ 53.51万
  • 项目类别:
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
  • 批准号:
    10653065
  • 财政年份:
    2020
  • 资助金额:
    $ 53.51万
  • 项目类别:
Subunit Vaccine for Cryptosporidiosis
隐孢子虫病亚单位疫苗
  • 批准号:
    10312809
  • 财政年份:
    2020
  • 资助金额:
    $ 53.51万
  • 项目类别:
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
  • 批准号:
    10443698
  • 财政年份:
    2020
  • 资助金额:
    $ 53.51万
  • 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
  • 批准号:
    10176548
  • 财政年份:
    2018
  • 资助金额:
    $ 53.51万
  • 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
  • 批准号:
    9754231
  • 财政年份:
    2018
  • 资助金额:
    $ 53.51万
  • 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
  • 批准号:
    10413887
  • 财政年份:
    2018
  • 资助金额:
    $ 53.51万
  • 项目类别:
Role of Type 2 Immunity in Innate Protection from C. difficile
2 型免疫在艰难梭菌先天保护中的作用
  • 批准号:
    10467414
  • 财政年份:
    2016
  • 资助金额:
    $ 53.51万
  • 项目类别:
Role of Type 2 Immunity in Innate Protection from C. difficile
2 型免疫在艰难梭菌先天保护中的作用
  • 批准号:
    10561651
  • 财政年份:
    2016
  • 资助金额:
    $ 53.51万
  • 项目类别:
Role of IL-23 in the Immunopathogenesis of C. difficile colitis
IL-23 在艰难梭菌结肠炎免疫发病机制中的作用
  • 批准号:
    9057951
  • 财政年份:
    2015
  • 资助金额:
    $ 53.51万
  • 项目类别:

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