NICHD Global Network for Women’s and Children’s Health Research: Research Units
NICHD 全球妇女和儿童健康研究网络:研究单位
基本信息
- 批准号:10746195
- 负责人:
- 金额:$ 53.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-10 至 2030-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAdoptionAnemiaAzithromycinBacteriuriaBangladeshBirthBudgetsCOVID-19Cellular PhoneChildChild DevelopmentChild HealthChildbirthChildhoodClinical ProtocolsClinical ResearchClinical Research ProtocolsClinical TrialsClinical Trials DesignClinical Trials NetworkCommunicable DiseasesCommunitiesConduct Clinical TrialsCountryDevelopmentDiarrheaEnrollmentEnvironmentEquipmentEquityEthical ReviewEthicsFertilityGenderGoalsGovernmentGrantHealthHealth care facilityHospitalsHuman GeneticsHuman ResourcesHuman RightsImmunologyImpairmentIncomeInfantInfant MalnutritionInservice TrainingInternationalKineticsLaboratoriesLactationLeadershipLow Birth Weight InfantMainstreamingMaternal MortalityMaternal and Child HealthMaternal-fetal medicineModelingMothersNational Institute of Child Health and Human DevelopmentNeonatal MortalityNeonatologyNeurocognitiveOccupational activity of managing financesOralOutcomeOutcome StudyPaperPharmacodynamicsPharmacologyPoliciesPopulationPregnancyPregnant WomenPrincipal InvestigatorProtocols documentationPublicationsPublishingRecording of previous eventsRegistriesRehydration SolutionsReproductive HealthResearchResearch PersonnelReservationsRespiratory Tract InfectionsRoleRuralRural PopulationSARS-CoV-2 infectionScienceScientistSepsisServicesSiteStructureTrainingTranslationsUnderrepresented MinorityUniversitiesUrban PopulationVirginiaVisitWomanclinical research sitecommunity based caredata centersdata communicationdesigndietary supplementselectronic dataequity, diversity, and inclusionexperiencefollow-upgender-based violenceglobal healthhealth of the motherimplementation scienceimprovedinnovationinventionlaboratory facilitymultidisciplinaryneonatal healthneurodevelopmentnovelnutritionpediatric pharmacologypreventrecruitvaccine failurevaccinology
项目摘要
PROJECT SUMMARY
Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately
from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, and maternal
mortality from childbirth, vaccine failure and impaired child development. The UVA-icddrb Research Unit (RU)
addresses critical needs of women and young children by bringing to the Network strengths in infectious
diseases, lactation, pharmacology, neurocognitive development, human genetics, maternal-fetal medicine,
immunology, vaccinology and CTSA coordination. The RU has access to nearly 8000 pregnant women
annually at our existing clinical trial sites, is highly attuned to ethical and cultural issues with local community
and ethical review boards, and leads Network studies of COVID-19 in pregnancy and maternal anemia.
Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul
Haque have for 30 years co-led multidisciplinary teams studying maternal-child health, with over 170 co-
publications and ten on-going or completed clinical studies in the last five years. They are joined at icddr,b and
UVA by a diverse and multidisciplinary core team of 19 accomplished investigators in maternal-child health.
Innovation: The RU conceptualized the multi-site study of COVID-19 infection during pregnancy that
demonstrated minimal impact on birth outcomes, is leading a study of the role of maternal anemia on low-birth
weight infants, has multi-site Network-approved protocols on maternal nutritional supplements and on
asymptomatic bacteriuria and has pioneered electronic data capture for the Network. Special capabilities
include infectious diseases, pharmacology, lactation, and novel clinical trial designs through the CTSA.
Approach: The RU has conducted 12 clinical trials since 2016 with 99% adherence to follow-up visits, and
access to 8000 pregnant women annually in existing clinical trial sites. Science to policy translation catalyzed
by the partnership of the icddr,b with the Government of Bangladesh, as evidenced by the worldwide
implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide, and the Matlab
model of community -based care.
Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban
and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in
the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases
and International Health has a unique focus on Global Health, with over $16 million in annual grant support and
over two dozen active clinical protocols. UVa-icddrb unique and complementary expertise will continue to bring
unparalleled strengths to the Network’s goal of making sustainable improvements in maternal and child health.
项目总结
意义:孟加拉国和其他中低收入国家的母亲和儿童遭受不成比例的痛苦
孕产妇和婴儿营养不良、新生儿因腹泻和呼吸道感染而死亡,以及孕产妇
分娩死亡率、疫苗失效和儿童发育受损。UVA-ICDDRB研究单位(RU)
通过发挥网络在传染病方面的优势,满足妇女和幼儿的迫切需求
疾病,哺乳,药理学,神经认知发育,人类遗传学,母婴医学,
免疫学、疫苗学和CTSA的协调。RU可以接触到近8000名孕妇
每年在我们现有的临床试验地点,与当地社区的伦理和文化问题高度协调
和伦理审查委员会,并领导新冠肺炎在怀孕和孕产妇贫血网络研究。
调查人员:RU首席调查员(PI)William Petri和高级外国调查员(SFI)Rashidul
30年来,哈克一直共同领导着研究母婴健康的多学科团队,有170多名
在过去五年中发表了10篇正在进行或已完成的临床研究。他们在ICDDR、b和
UVA由一个由19名在母婴健康方面有成就的研究人员组成的多元化和多学科核心团队。
创新:RU概念化了孕期新冠肺炎感染的多点研究
证明对出生结局的影响很小,正在领导一项关于母亲贫血对低出生的作用的研究
婴儿体重,有多站点网络批准的关于母亲营养补充剂等的协议
无症状菌尿,并开创了网络电子数据捕获的先河。特殊能力
包括传染病、药理学、哺乳和通过CTSA进行的新的临床试验设计。
方法:自2016年以来,RU已经进行了12项临床试验,99%的人坚持随访,以及
在现有的临床试验地点,每年可接触到8000名孕妇。科学到政策的转化是催化的
通过红十字国际委员会b与孟加拉国政府的伙伴关系,世界各地的
实施口服补液溶液,在ICDDR,b发现,并在全国范围内采用,以及MatLab
基于社区的护理模式。
环境:RU拥有无与伦比的多学科实力、实验室设施和进入城市的通道
以及农村人口的母亲和儿童。ICDDR,b是全球最重要的卫生机构之一
发展中国家拥有200多项正在进行的临床试验/方案。弗吉尼亚大学传染病学部
国际卫生组织对全球卫生有独特的关注,每年提供1600多万美元的赠款支持和
超过24个有效的临床方案。UVA-ICDDRB独特和互补的专业知识将继续带来
这是该网络在妇幼保健方面取得可持续改善的目标的无与伦比的优势。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study.
孟加拉国农村地区早产期的全身性炎症,肠病大肠杆菌和微量营养素不足,可能是早产的预测指标:一项前瞻性研究。
- DOI:10.1186/s12884-024-06266-9
- 发表时间:2024-01-24
- 期刊:
- 影响因子:3.1
- 作者:
- 通讯作者:
Setting up a maternal and newborn registry applying electronic platform: an experience from the Bangladesh site of the global network for women's and children's health.
- DOI:10.1186/s12978-020-00993-w
- 发表时间:2020-11-30
- 期刊:
- 影响因子:3.4
- 作者:Billah SM;Haque R;Chowdhury AI;Siraj MS;Rahman QS;Hossain T;Alam A;Alam M;Marie C;McGrath B;El Arifeen S;Petri WA Jr
- 通讯作者:Petri WA Jr
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William A Petri其他文献
Environmental enteropathy and malnutrition: do we know enough to intervene?
- DOI:
10.1186/s12916-014-0187-1 - 发表时间:
2014-10-14 - 期刊:
- 影响因子:8.300
- 作者:
William A Petri;Caitlin Naylor;Rashidul Haque - 通讯作者:
Rashidul Haque
The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction
环境肠道功能障碍活检倡议(EEDBI)联盟:环境肠道功能障碍的黏膜研究
- DOI:
10.1016/j.ajcnut.2024.02.003 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Donna M Denno;Sheraz Ahmed;Tahmeed Ahmed;S Asad Ali;Beatrice Amadi;Paul Kelly;Sarah Lawrence;Mustafa Mahfuz;Chelsea Marie;Sean R Moore;James P Nataro;William A Petri;Peter B Sullivan;Phillip I Tarr;Kumail Ahmed;Md Ashraful Alam;Barrett H Barnes;SM Khodeza Nahar Begum;Stephen M Borowitz;Kanta Chandwe;Fayaz Umrani - 通讯作者:
Fayaz Umrani
Histopathology underlying environmental enteric dysfunction in a cohort study of undernourished children in Bangladesh, Pakistan, and Zambia compared with United States children
孟加拉国、巴基斯坦和赞比亚营养不良儿童队列研究与美国儿童相比的环境性肠功能障碍的组织病理学基础
- DOI:
10.1016/j.ajcnut.2024.02.028 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Paul Kelly;Kelley VanBuskirk;David Coomes;Samer Mouksassi;Gerald Smith;Zehra Jamil;Md Shabab Hossain;Sana Syed;Chelsea Marie;Phillip I Tarr;Peter B Sullivan;William A Petri;Donna M Denno;Tahmeed Ahmed;Mustafa Mahfuz;S Asad Ali;Sean R Moore;I Malick Ndao;Guillermo J Tearney;Ömer H Yilmaz;Kanekwa Zyambo - 通讯作者:
Kanekwa Zyambo
Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction
环境性肠功能障碍中小肠炎症和上皮参数的多重免疫组化评估
- DOI:
10.1016/j.ajcnut.2024.02.033 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Kelley VanBuskirk;Monica Mweetwa;Tad Kolterman;Shyam Raghavan;Tahmeed Ahmed;S Asad Ali;SM Khodeza Nahar Begum;Ellen Besa;Donna M Denno;Zehra Jamil;Paul Kelly;Mustafa Mahfuz;Sean R Moore;Samer Mouksassi;William A Petri;Phillip I Tarr;Peter B Sullivan;Christopher A Moskaluk;Kumail Ahmed;Sheraz Ahmed;Omer H Yilmaz - 通讯作者:
Omer H Yilmaz
Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers
十二指肠转录组学显示了全球多个中心环境肠道功能障碍儿童组织炎症和免疫细胞浸润的特征
- DOI:
10.1016/j.ajcnut.2024.02.023 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:6.900
- 作者:
Chelsea Marie;Subhasish Das;David Coomes;Tahmeed Ahmed;S Asad Ali;Junaid Iqbal;Paul Kelly;Mustafa Mahfuz;Sean R Moore;William A Petri;Phillip I Tarr;Lee A Denson;Kumail Ahmed;Sheraz Ahmed;Md Ashraful Alam;David Auble;SM Khodeza Nahar Begum;Ellen Besa;Mubanga Chama;Donna M Denno;Kanekwa Zyambo - 通讯作者:
Kanekwa Zyambo
William A Petri的其他文献
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{{ truncateString('William A Petri', 18)}}的其他基金
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
- 批准号:
10223165 - 财政年份:2020
- 资助金额:
$ 53.51万 - 项目类别:
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
- 批准号:
10653065 - 财政年份:2020
- 资助金额:
$ 53.51万 - 项目类别:
Role of Th17 in Severe and Recurrent C. difficile Infection
Th17 在严重和复发性艰难梭菌感染中的作用
- 批准号:
10443698 - 财政年份:2020
- 资助金额:
$ 53.51万 - 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
- 批准号:
10176548 - 财政年份:2018
- 资助金额:
$ 53.51万 - 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
- 批准号:
9754231 - 财政年份:2018
- 资助金额:
$ 53.51万 - 项目类别:
University of Virginia - icddr,b Research Unit for Women's and Children's Health Research
弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位
- 批准号:
10413887 - 财政年份:2018
- 资助金额:
$ 53.51万 - 项目类别:
Role of Type 2 Immunity in Innate Protection from C. difficile
2 型免疫在艰难梭菌先天保护中的作用
- 批准号:
10467414 - 财政年份:2016
- 资助金额:
$ 53.51万 - 项目类别:
Role of Type 2 Immunity in Innate Protection from C. difficile
2 型免疫在艰难梭菌先天保护中的作用
- 批准号:
10561651 - 财政年份:2016
- 资助金额:
$ 53.51万 - 项目类别:
Role of IL-23 in the Immunopathogenesis of C. difficile colitis
IL-23 在艰难梭菌结肠炎免疫发病机制中的作用
- 批准号:
9057951 - 财政年份:2015
- 资助金额:
$ 53.51万 - 项目类别:
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