NICHD Global Network for Women’s and Children’s Health Research: Research Units

NICHD 全球妇女和儿童健康研究网络：研究单位

• 批准号: 10746195
• 负责人: William A Petri
• 金额: $ 53.51万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-10 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746195
• 关键词: Address; Adherence; Adoption; Anemia; Azithromycin; Bacteriuria; Bangladesh; Birth; Budgets; COVID-19; Cellular Phone; Child; Child Development; Child Health; Childbirth; Childhood; Clinical Protocols; Clinical Research; Clinical Research Protocols; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Communicable Diseases; Communities; Conduct Clinical Trials; Country; Development; Diarrhea; Enrollment; Environment; Equipment; Equity; Ethical Review; Ethics; Fertility; Gender; Goals; Government; Grant; Health; Health care facility; Hospitals; Human Genetics; Human Resources; Human Rights; Immunology; Impairment; Income; Infant; Infant Malnutrition; Inservice Training; International; Kinetics; Laboratories; Lactation; Leadership; Low Birth Weight Infant; Mainstreaming; Maternal Mortality; Maternal and Child Health; Maternal-fetal medicine; Modeling; Mothers; National Institute of Child Health and Human Development; Neonatal Mortality; Neonatology; Neurocognitive; Occupational activity of managing finances; Oral; Outcome; Outcome Study; Paper; Pharmacodynamics; Pharmacology; Policies; Population; Pregnancy; Pregnant Women; Principal Investigator; Protocols documentation; Publications; Publishing; Recording of previous events; Registries; Rehydration Solutions; Reproductive Health; Research; Research Personnel; Reservations; Respiratory Tract Infections; Role; Rural; Rural Population; SARS-CoV-2 infection; Science; Scientist; Sepsis; Services; Site; Structure; Training; Translations; Underrepresented Minority; Universities; Urban Population; Virginia; Visit; Woman; clinical research site; community based care; data centers; data communication; design; dietary supplements; electronic data; equity, diversity, and inclusion; experience; follow-up; gender-based violence; global health; health of the mother; implementation science; improved; innovation; invention; laboratory facility; multidisciplinary; neonatal health; neurodevelopment; novel; nutrition; pediatric pharmacology; prevent; recruit; vaccine failure; vaccinology

PROJECT SUMMARY Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, and maternal mortality from childbirth, vaccine failure and impaired child development. The UVA-icddrb Research Unit (RU) addresses critical needs of women and young children by bringing to the Network strengths in infectious diseases, lactation, pharmacology, neurocognitive development, human genetics, maternal-fetal medicine, immunology, vaccinology and CTSA coordination. The RU has access to nearly 8000 pregnant women annually at our existing clinical trial sites, is highly attuned to ethical and cultural issues with local community and ethical review boards, and leads Network studies of COVID-19 in pregnancy and maternal anemia. Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul Haque have for 30 years co-led multidisciplinary teams studying maternal-child health, with over 170 co- publications and ten on-going or completed clinical studies in the last five years. They are joined at icddr,b and UVA by a diverse and multidisciplinary core team of 19 accomplished investigators in maternal-child health. Innovation: The RU conceptualized the multi-site study of COVID-19 infection during pregnancy that demonstrated minimal impact on birth outcomes, is leading a study of the role of maternal anemia on low-birth weight infants, has multi-site Network-approved protocols on maternal nutritional supplements and on asymptomatic bacteriuria and has pioneered electronic data capture for the Network. Special capabilities include infectious diseases, pharmacology, lactation, and novel clinical trial designs through the CTSA. Approach: The RU has conducted 12 clinical trials since 2016 with 99% adherence to follow-up visits, and access to 8000 pregnant women annually in existing clinical trial sites. Science to policy translation catalyzed by the partnership of the icddr,b with the Government of Bangladesh, as evidenced by the worldwide implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide, and the Matlab model of community -based care. Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases and International Health has a unique focus on Global Health, with over $16 million in annual grant support and over two dozen active clinical protocols. UVa-icddrb unique and complementary expertise will continue to bring unparalleled strengths to the Network’s goal of making sustainable improvements in maternal and child health.

项目总结

项目成果

Systemic inflammation, enteropathogenic E. Coli, and micronutrient insufficiencies in the first trimester as possible predictors of preterm birth in rural Bangladesh: a prospective study.

孟加拉国农村地区早产期的全身性炎症，肠病大肠杆菌和微量营养素不足，可能是早产的预测指标：一项前瞻性研究。

• DOI: 10.1186/s12884-024-06266-9
• 发表时间: 2024-01-24
• 期刊: BMC pregnancy and childbirth
• 影响因子: 3.1

Setting up a maternal and newborn registry applying electronic platform: an experience from the Bangladesh site of the global network for women's and children's health.

• DOI: 10.1186/s12978-020-00993-w
• 发表时间: 2020-11-30
• 期刊: Reproductive health
• 影响因子: 3.4
• 作者: Billah SM;Haque R;Chowdhury AI;Siraj MS;Rahman QS;Hossain T;Alam A;Alam M;Marie C;McGrath B;El Arifeen S;Petri WA Jr
• 通讯作者: Petri WA Jr