Electronic Bypass for Diabetes

糖尿病电子旁路

基本信息

  • 批准号:
    10179364
  • 负责人:
  • 金额:
    $ 45.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-07-01 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

Diabetes affects more than 9% of Americans and costs over $245 billion in 2012 in USA. Recently bariatric surgery, such as Roux-en-Y gastric bypass and sleeve gastrectomy, has been proposed for treating diabetic patients with obesity due to its hypoglycemic effect on postprandial blood glucose and significant weight loss. A novel method of intestinal electrical stimulation (IES) is proposed for the treatment of diabetes in this application. In this method, IES is designed to alter gastrointestinal transit and hormones, including incretin hormones, such as glucagon like peptide-1 (GLP-1). Our preliminary studies have demonstrated acceleration of intestinal transit, an increase in postprandial GLP-1 and a reduction in blood glucose after oral glucose. Chronically, the proposed IES has resulted in improvement in glycemic control and improvement in pancreatic islets functions. According to these findings, we hypothesize that the acute hypoglycemic effect of IES in the postprandial state is attributed to IES-induced enhancement in the release of GLP-1 and possibly other hormones as well, such as ghrelin, and that the chronic hypoglycemic effect of IES in both fasting and fed states is attributed to improvement in beta-cell functions, attributed to the prevention of the detrimental effects of hyperglycemia and the ameliorating effect of IES-induced elevated GLP-1 on beta-cell functions. The project will be performed using advanced technologies (wireless stimulation and recording cages, and autonomic and continuous food intake monitoring) that allow IES to be conducted in freely moving animals. The best characterized animal model of spontaneous Type 2 diabetes, the Goto-Kakizaki (GK) rat will be used to accomplish following specific aims: 1) To optimize IES parameters, develop on-demand IES and perform closed-loop IES. First, we will systematically optimized stimulation parameters to maximize the hypoglycemic effect of IES. Then we will develop an algorithm to automatically detect food intake and then trigger IES upon food ingestion. It will be based on characteristics of intrinsic intestinal myoelectrical activity and artificial neural network. The meal triggered IES will avoid excessive stimulation. Finally, a closed-loop IES method (each stimulus is synchronized with intrinsic intestinal myoelectrical activity) will be developed to further increase the efficacy of IES for diabetes. 2) To study the hypoglycemic mechanisms of acute IES involving incretin hormones, such as GLP-1, and ghrelin, and the intestinal transit mechanisms involved in the IES-induced elevation of insulin-stimulating gastrointestinal hormones. 3) To explore cellular mechanisms of chronic IES on long-term glycemic control. Chronic IES will be performed to investigate long-term hypoglycemic effects of IES in both fasting and fed states, and mechanisms involving pancreatic islets functions, beta-cell apoptosis and proliferation, and a number of transcription factors involved in the regulation of β-cell development, differentiation and function. Possible involvement of L-cells in the distal gut will also be investigated.
糖尿病影响了超过9%的美国人,2012年在美国的花费超过2450亿美元。最近减肥

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jiande Chen其他文献

Jiande Chen的其他文献

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{{ truncateString('Jiande Chen', 18)}}的其他基金

Interrogating the pathophysiological mechanisms of constipation in patients with systemic sclerosis
探讨系统性硬化症患者便秘的病理生理机制
  • 批准号:
    10659640
  • 财政年份:
    2023
  • 资助金额:
    $ 45.33万
  • 项目类别:
AccelBand, a leg-worn transcutaneous neuromodulation device for treating neurogenic bowel dysfunction in individuals with spinal cord injury
AccelBand,一种腿戴式经皮神经调节装置,用于治疗脊髓损伤患者的神经源性肠功能障碍
  • 批准号:
    10492922
  • 财政年份:
    2022
  • 资助金额:
    $ 45.33万
  • 项目类别:
Use of novel MRI technology to study pathophysiology diabetic gastroparesis
利用新型 MRI 技术研究糖尿病性胃轻瘫的病理生理学
  • 批准号:
    10363841
  • 财政年份:
    2021
  • 资助金额:
    $ 45.33万
  • 项目类别:
Functional Neural Circuits of Stomach-Brain Interoception
胃脑内感受的功能神经回路
  • 批准号:
    10320254
  • 财政年份:
    2021
  • 资助金额:
    $ 45.33万
  • 项目类别:
Use of novel MRI technology to study pathophysiology diabetic gastroparesis
利用新型 MRI 技术研究糖尿病性胃轻瘫的病理生理学
  • 批准号:
    10701893
  • 财政年份:
    2021
  • 资助金额:
    $ 45.33万
  • 项目类别:
Functional Neural Circuits of Stomach-Brain Interoception
胃脑内感受的功能神经回路
  • 批准号:
    10698021
  • 财政年份:
    2021
  • 资助金额:
    $ 45.33万
  • 项目类别:
Home-based transcutaneous electrical acustimulation for abdominal pain
家庭经皮电针治疗腹痛
  • 批准号:
    10619029
  • 财政年份:
    2020
  • 资助金额:
    $ 45.33万
  • 项目类别:
Home-based transcutaneous electrical acustimulation for abdominal pain
家庭经皮电针治疗腹痛
  • 批准号:
    10045379
  • 财政年份:
    2020
  • 资助金额:
    $ 45.33万
  • 项目类别:
Home-based transcutaneous electrical acustimulation for abdominal pain
家庭经皮电针治疗腹痛
  • 批准号:
    10685484
  • 财政年份:
    2020
  • 资助金额:
    $ 45.33万
  • 项目类别:
Intrinsic disorder controls the function of p53 and other cancer associated IDPs
内在紊乱控制 p53 和其他癌症相关 IDP 的功能
  • 批准号:
    9279187
  • 财政年份:
    2016
  • 资助金额:
    $ 45.33万
  • 项目类别:

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