IMPACC-MEDVAMC
IMPACC-MEDVAMC
基本信息
- 批准号:10202368
- 负责人:
- 金额:$ 16.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2022-02-28
- 项目状态:已结题
- 来源:
- 关键词:Airway DiseaseAllergicAllergic inflammationAnimal ModelAntifungal AgentsAsthmaB-LymphocytesBindingBiologicalBlood Coagulation FactorBudgetsCOVID-19CellsChronicCleaved cellClinicalClinical Course of DiseaseClinical DataCoagulantsCohort StudiesCoinDataData CollectionDecision MakingDiagnosisDiseaseEnrollmentEpithelial CellsFibrinogenFungal AntigensGoalsGrowthHumanITGAM geneITGB2 geneImmuneImmune System DiseasesImmune responseImmunityImmunophenotypingIn VitroIndividualInhalationInnate Immune ResponseInpatientsInstitutionIntegrinsInterventionLeadLinkLower respiratory tract structureLung InflammationMacrophage-1 AntigenMediatingMedical centerMedicineMoldsMolecularMolecular ProfilingMusMutationPathogenesisPathway interactionsPatientsPeptide HydrolasesPhenotypePhysiologicalReproduction sporesResearchRoleSTAT6 geneSamplingSignal TransductionT-LymphocyteTLR4 geneTestingTissue-Specific Gene ExpressionUnited States National Institutes of HealthVirus Diseasesairway epitheliumairway hyperresponsivenessallergic airway diseaseallergic airway inflammationasthmaticbasechronic rhinosinusitiscohortcollegecoronavirus diseasefungushuman diseaseimmune activationimprovedmacrophagemolecular markermonocyteparent grantpatient subsetspreventresponsesample collectionscreeningtranscriptometranscriptome sequencingtrend
项目摘要
The objective of this supplement proposal is to understand the causes of airway diseases and thereby improve
diagnosis and therapy of these common and debilitating of human ailments. The Immunophenotyping
Assessment in a COVID-19 Cohort (IMPACC) study coordinates a national, multi-institution consortium,
collecting detailed clinical data and biologic samples from hospitalized COVID-19 infected individuals, with the
goal of identifying immune signatures/molecular biomarkers associated with clinical disease course, to allow
the prioritization of clinical interventions and decision making. This supplement supports Baylor College of
Medicine's and the Michael E. DeBakey VA Medical Center's (MEDVAMC) participation in IMPACC to facilitate
screening and enrollment of inpatients with COVID-19. The proposed supplement research is within the scope
of parent grant R01 AI135803, Fungal Pathogenesis of Moderate to Severe Asthma. This supplement is
submitted for the purpose of Clinical data and sample collection/processing and the scope will be confined to
patients confirmed to have COVID-19. Based on projected trends in COVID-19 disease in MEDVAMC, we
estimate that up to 50 COVID-19 patients can be enrolled within 6 months. As enrollees will be followed for up
to one year, the budget extends to 18 months. Data to be collected will consist of both primary and secondary
clinical and mechanistic endpoints as well as exploratory clinical and mechanistic endpoints.
这项补充建议的目的是了解呼吸道疾病的原因,从而改善
诊断和治疗这些常见的、使人衰弱的疾病。免疫表型
新冠肺炎队列研究(IMPACC)中的评估协调了一个全国性的多机构联盟,
收集住院新冠肺炎感染者的详细临床数据和生物样本,
识别与临床病程相关的免疫特征/分子生物标记物的目标,以允许
确定临床干预和决策的优先顺序。本附录支持贝勒学院
Mediced和Michael E.DeBakey VA医疗中心(MEDVAMC)参与IMPACC以促进
住院新冠肺炎患者的筛查和入选。建议的补充研究在以下范围内
家长基金R01 AI135803,中重度哮喘的真菌发病机制。这份副刊是
为临床数据和样本收集/处理的目的而提交,范围将限于
确诊患有新冠肺炎的患者。根据MEDVAMC对新冠肺炎病的预测趋势,我们
预计6个月内可入选多达50名新冠肺炎患者。因为参赛者将被跟踪
到一年,预算延长到18个月。要收集的数据将包括主要数据和次要数据
临床和机械终端以及探索性临床和机械终端。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DAVID B CORRY其他文献
DAVID B CORRY的其他文献
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{{ truncateString('DAVID B CORRY', 18)}}的其他基金
Molecular and Cellular Dissection of miRNAs in Controlling Allergic Airway Inflammation in Mice
miRNA 在控制小鼠过敏性气道炎症中的分子和细胞解析
- 批准号:
10477187 - 财政年份:2020
- 资助金额:
$ 16.29万 - 项目类别:
Molecular and Cellular Dissection of miRNAs in Controlling Allergic Airway Inflammation in Mice
miRNA 在控制小鼠过敏性气道炎症中的分子和细胞解析
- 批准号:
10664926 - 财政年份:2020
- 资助金额:
$ 16.29万 - 项目类别:
Molecular and Cellular Dissection of miRNAs in Controlling Allergic Airway Inflammation in Mice
miRNA 在控制小鼠过敏性气道炎症中的分子和细胞解析
- 批准号:
10012111 - 财政年份:2020
- 资助金额:
$ 16.29万 - 项目类别:
MECHANISM AND FUNCTION OF LET-7, A NOVEL MODULATOR OF TH17-DEPENDENT EMPHYSEMA
TH17 依赖性肺气肿的新型调节剂 Let-7 的机制和功能
- 批准号:
10240489 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
MECHANISM AND FUNCTION OF LET-7, A NOVEL MODULATOR OF TH17-DEPENDENT EMPHYSEMA
TH17 依赖性肺气肿的新型调节剂 Let-7 的机制和功能
- 批准号:
10470262 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
Pathogenesis of Polymicrobial Cerebritis-Related Dementia
多种微生物脑炎相关痴呆的发病机制
- 批准号:
10119639 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
FUNGAL PATHOGENESIS OF MODERATE TO SEVERE ASTHMA
中度至重度哮喘的真菌发病机制
- 批准号:
10357580 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
MECHANISM AND FUNCTION OF LET-7, A NOVEL MODULATOR OF TH17-DEPENDENT EMPHYSEMA
TH17 依赖性肺气肿的新型调节剂 Let-7 的机制和功能
- 批准号:
9766362 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
MECHANISM AND FUNCTION OF LET-7, A NOVEL MODULATOR OF TH17-DEPENDENT EMPHYSEMA
TH17 依赖性肺气肿的新型调节剂 Let-7 的机制和功能
- 批准号:
10001079 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
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