The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

联系人 PD/PI：Jackson、Rebecca D 概述 摘要 自成立以来，俄亥俄州立大学临床和临床中心的首要使命是 转化科学 (CCTS) 雄心勃勃：推进当今的发现以改善健康。我们 通过提供临床和转化科学（CTS）资源、教育、 和培训途径，并通过促进变革性方法的进步来催化和维持 转化科学创新。我们与我们的儿科合作伙伴全国儿童医院合作， 已经为具有变革性的转化生物医学科学制定了一致的愿景。至 继续我们的使命，我们建议从催化转化科学创新和团队出发 本地科学，以促进有意义的临床和转化科学合作 社区、学术界、行业和政府合作伙伴以及 CTSA 联盟的成员。 我们将加强和扩大 CTS 多元化员工队伍的培训、职业发展和可持续性 通过提供全面的、可获得的教育资源和机会（劳动力 发展）并让广泛的利益相关者成为全方位转化的合作伙伴 从研究开始到结果传播，研究作为积极的团队参与者（协作和 订婚）。我们将提供新的方法和资源，以加强对那些已经经历过这种情况的人群的包容。 传统上被排除或孤立研究，支持和加强跨越转化的研究 通过积极减少参与研究的障碍并促进研究成果的转化来扩大研究范围 临床和人群以及整个生命周期的发现（整合）。此外，我们还将推动 创新、质量和效率，通过综合系统推进转化科学 转化研究资源（方法和过程）。最后，我们将嵌入信息学和数据 涵盖 OSU-CCTS 中所有项目以及整个转化研究领域的分析解决方案 （信息学）通过在安全的数据环境中集成和询问研究数据，开发和 采用促进研究的创新方法和工具，并为数据科学提供重要基础 对于转化科学工作者来说。未来5年，我们将提供强大的研究基础设施 以及以当地创新为基础并由 采用 CTSA 联盟确定的最佳实践。通过利用我们的跨学科科学 凭借优势、专业知识和观点，OSU-CCTS 将促进生物医学研究转化。与一个 致力于实验，我们将找出差距和挑战，系统地开发和研究 （展示）新的方法和途径，并传播有效的战略和教育举措 这将改变当地和全国的临床和转化科学。 项目总结/摘要第 275 页 联系人 PD/PI：Jackson、Rebecca D

Contact PD/PI: Jackson, Rebecca D OVERVIEW SUMMARY Since our inception, the overarching mission of The Ohio State University’s Center for Clinical and Translational Science (CCTS) has been ambitious: to advance today’s discoveries to improve health. We do this by providing an integrated environment of clinical and translational science (CTS) resources, education, and training pathways and by promoting transformative methodologic advances to catalyze and sustain translational science innovation. In collaboration with our pediatric partner, Nationwide Children’s Hospital, we have developed an aligned vision for translational biomedical science that has been transformative. To continue with our mission, we propose to advance from catalyzing translational science innovation and team science locally to facilitating meaningful clinical and translational science collaborations with community, academic, industry, and government partners and with members of the CTSA Consortium. We will enhance and expand the training, career development, and sustainability of a diverse CTS workforce through the provision of comprehensive, accessible education resources and opportunities (Workforce Development) and engage a broad range of stakeholders as partners in the full spectrum of translational research as active team participants from study inception through dissemination of results (Collaboration and Engagement). We will provide new approaches and resources to enhance inclusion of populations that have traditionally been excluded or studied in isolation and support and enhance studies that span the translational research spectrum by actively reducing barriers to research study participation and catalyzing the translation of discoveries to the clinic and population and across the lifespan (Integration). Moreover, we will promote innovation, quality, and efficiency to advance translational science through an integrated system of translational research resources (Methods and Processes). Finally, we will embed informatics and data analytic solutions across all programs in the OSU-CCTS and across the full spectrum of translational research (Informatics) by integrating and interrogating research data within a secure data environment, develop and adopt innovative methods and tools that facilitate research, and provide a critical foundation in data sciences for the translational science workforce. Over the next 5 years, we will provide a robust research infrastructure and comprehensive research training programs informed by local innovations and strengthened by the adoption of best practices identified by the CTSA Consortium. By leveraging our interdisciplinary scientific strengths, expertise, and perspectives, the OSU-CCTS will catalyze biomedical research translation. With a commitment to experimentation, we will identify gaps and challenges, systematically develop and study (demonstrate) new methods and approaches, and disseminate effective strategies and educational initiatives that will transform clinical and translational science both locally and nationally. Project Summary/Abstract Page 275 Contact PD/PI: Jackson, Rebecca D