Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking among Homeless Adults

项目总结/摘要 无家可归的成年人酒精依赖的可能性是普通成年人的8倍， 然而，很少有研究探讨了这一弱势群体饮酒的诱因。这种缺乏 信息是为无家可归的成年人开发有效的酒精治疗方法的障碍， 排除在临床试验之外。R34 AA 024584 - 01 A1正在开发和测试一种“即时”自适应 智能手机干预，以减少无家可归的男性和女性的酒精使用。我们已经完成了第一阶段 （识别预测即将饮酒的“当下”风险因素），并接近完成阶段 2（开发预测算法、治疗消息和基于治疗消息传递消息的应用程序 4小时内“立即饮酒”的风险）。在第三阶段，我们将测试可行性、可接受性和 该应用程序在无家可归的成年人新样本中的初步疗效。根据公共卫生建议 在2019冠状病毒病期间，我们于2020年2月下旬开始缩减人类受试者活动。遵守 根据大学指令，我们于2020年3月17日停止了人类受试者活动。我们希望恢复人类实验 研究于2020年7月。2019冠状病毒病的干扰导致了估计4个月的延迟， 人类受试者的角度;当前的补充申请是完成第3阶段（目标3）所必需的。 项目

PROJECT SUMMARY/ABSTRACT Homeless adults are 8 times as likely to be alcohol dependent compared with adults in the general population, yet few studies have examined the precipitants of alcohol use in this vulnerable population. This lack of information is a barrier to developing effective alcohol treatments for homeless adults, a population that is often excluded from clinical trials. R34 AA024584-01A1 is developing and testing a “just-in-time” adaptive smartphone intervention to reduce alcohol use in homeless men and women. We have completed Phase 1 (identification of “in-the-moment” risk factors that predict imminent drinking) and are nearly finished with Phase 2 (development of the prediction algorithm, treatment messages, and an app to deliver messages based on the risk of “imminent drinking” within four hours). In Phase 3, we will test the feasibility, acceptability, and preliminary efficacy of the app in a new sample of homeless adults. Following public health recommendations around COVID-19, we began to curtail our human subjects activities in late February, 2020. To comply with university directives, we ceased human subjects activities on 3/17/20. We expect to resume human subjects research in July, 2020. Disruptions from COVID-19 have resulted in an estimated 4 months of delay from a human subjects perspective; the current supplement request is necessary to complete Phase 3 (Aim 3) of the project.