Supplement - Understanding The Risk of Obesity in Food-Insecure Children: The Hidden Role of Stress

项目摘要/摘要 粮食不安全是一种食物供应有限的家庭状况，目前影响着1500万美国儿童。食物-- 缺乏安全感的儿童面临与饮食相关的不良健康状况的风险；然而，潜在的机制 这些关联还没有被明确识别出来。K99/R00独立之路奖 (HD084758)专注于应激作为一种新的和重要的途径的作用来解释 粮食不安全对儿童的发育和与饮食有关的结果的影响。具体地说，R00项目是 对167名居住在密歇根州的低收入儿童和母亲的纵向研究，调查食物不安全 通过压力和与进食相关的认知过程影响体重增加。因为 涉及人类受试者的研究因新冠肺炎而被无限期暂停，这是为了 行政补充是远程完成对剩余的128个家庭的数据收集 参加了这项研究。完成剩余家庭的数据收集对于实现最初的 这项研究的目的是因为主要结果是儿童和母亲在12个月内体重增加。我 在无需面对面接触的情况下收集高质量的健康数据方面有丰富的研究经验，并拥有 为低收入儿童和母亲制定了一项高度可行的远程数据收集协议 参加了这项研究。行政补编将使我们能够立即重新开始收集数据。 并实现项目最初提出的目标。R00项目的成功完成将导致 几个可出版的手稿，并进一步协助撰写后续的NIH赠款，以了解和 改善低收入人口的粮食不安全和与饮食有关的健康差距。

PROJECT SUMMARY/ ABSTRACT Food insecurity, a household condition of limited food availability, affects 15 million US children today. Food- insecure children are at risk for adverse diet-related health conditions; however, the mechanisms underlying these associations have not been clearly identified. The K99/R00 Pathway to Independence Award (HD084758) focuses on the role of stress as a novel and important pathway to explain the adverse effects of food insecurity on children’s developmental and diet-related outcomes. Specifically, the R00 project is a longitudinal study of 167 low-income, Michigan-dwelling children and mothers investigating how food insecurity impacts weight gain through the pathways of stress and cognitive processes related to eating. Because research involving human subjects have been paused indefinitely due to COVID-19, the purpose of this Administrative Supplement is to complete data collection remotely for the 128 remaining families already enrolled in the study. Completing data collection for the remaining families is critical to achieving the original study aims because the primary outcomes are weight gain in children and mothers over a 12-month period. I have ample research experience in collecting high-quality health data without in-person contact, and have developed a highly feasible protocol for remote data collection for the low-income children and mothers already enrolled in the study. The Administrative Supplement will allow us to recommence data collection immediately and fulfill the project’s aims as originally proposed. Successful completion of the R00 project will lead to several publishable manuscripts, and further assist in writing subsequent NIH grants to understanding and improving food insecurity and diet-related health disparities in low-income populations.