Molecular interception and immunological characterization of age-associated disease

年龄相关疾病的分子拦截和免疫学表征

基本信息

  • 批准号:
    10190562
  • 负责人:
  • 金额:
    $ 63.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-21 至 2026-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY In developed countries, noncommunicable diseases such as cancer, cardiovascular disease, chronic respiratory illness, and diabetes account for the majority of deaths among people aged 70 and older. The global economic burden to care for patients with noncommunicable diseases is astronomical. In 2010, it cost an estimated 47 trillion dollars in 2010-2030, which is equivalent to 75% of global gross domestic product in 2010, to provide care for patients with chronic disease. Clearly, we need a better strategy to identify patients at greatest risk so that we can prevent disease development or provide earlier intervention. Our recent work has suggested that a decline in immune function is a major, potentially modifiable, risk factor for the development of cardiovascular disease. It remains unclear, however, at what point in the patient’s lifespan does the immune system age and contribute to disease, how genetic and environmental factors affect immune age, and whether decline in immune function is also associated with the development of other noncommunicable diseases associated with chronological aging. Project 2 is designed to understand the relationship between immune-aging (whose deepened understanding and relationship to flu response we assess in Project 1) and the development of diseases associated with chronological aging - an association that we hypothesize begins in middle-age but extends throughout the individual’s life span. In Project 2, first, we add a middle age cohort of twins (MAT-SELA) demographically similar to the SELA cohort, to not only expand the age range of patients to be profiled, but also to disentangle the effects of genetics and the environment to immune aging. To further isolate the environmental effects on immune age, we will also compare the immune age of a super fit older cohort (AL-SELA) with that of the SELA cohort, who are normal, older patients leading sedentary lifestyles. Second, we perform an in-depth analysis of how immune age affects the development of cardiovascular disease, building from our previous work, by serially profiling the immune age of patients who are at greatest risk for developing atherosclerosis (e.g., plaque build-up, heart attack or stroke), monitoring these patients by non-invasive imaging for the development and/or progression of cardiovascular disease, and documenting any major adverse clinical events. Furthermore, we apply advanced immune-based assays developed by our lab to interrogate the molecular and cellular components of the atherosclerotic plaque, extending our recent finding that flu specific T cells are found in the atherosclerotic plaque, in order to better understand the underlying mechanisms behind recent clinical observations that having the flu increases the risk of heart attack and stroke. Lastly, we will determine if immune age contributes to other non-communicable diseases by comparing the immune gene signatures associated with advanced aging in our cohorts with publicly available databases to associate the immune state with disease likelihood, severity, and prognosis.
项目摘要 在发达国家,癌症、心血管疾病、慢性呼吸道疾病等非传染性疾病 疾病和糖尿病是70岁及以上老年人死亡的主要原因。全球经济 照顾非传染性疾病患者的负担是天文数字。2010年,估计花费了47 在2010-2030年期间,将投入2000亿美元,相当于2010年全球国内生产总值的75%, 对于慢性病患者。显然,我们需要一个更好的策略来识别风险最大的患者, 我们可以预防疾病发展或提供早期干预。我们最近的研究表明, 免疫功能下降是心血管疾病发展的一个主要的、潜在的、可改变的危险因素。 疾病然而,目前还不清楚患者的免疫系统在生命周期的哪个阶段老化, 有助于疾病,遗传和环境因素如何影响免疫年龄,以及免疫力是否下降, 功能也与其他非传染性疾病的发展有关, 时间老化项目2旨在了解免疫衰老(其 加深了对我们在项目1)中评估的流感应对的理解和关系, 与时间老化相关的疾病-我们假设这种关联始于中年, 贯穿于个体的一生。在项目2中,首先,我们添加了一个中年双胞胎队列(MAT-SELA) 在人口统计学上与SELA队列相似,不仅扩大了待分析患者的年龄范围,而且 解开遗传和环境对免疫衰老的影响。为了进一步隔离环境 影响免疫年龄,我们还将比较一个超级适合老年队列(AL-SELA)的免疫年龄与 SELA队列,他们是正常的,老年患者,生活方式久坐不动。第二,我们深入 分析免疫年龄如何影响心血管疾病的发展,建立在我们以前的工作, 通过连续分析处于发展动脉粥样硬化最大风险的患者的免疫年龄(例如, 斑块积聚、心脏病发作或中风),通过非侵入性成像监测这些患者, 和/或心血管疾病进展,并记录任何主要不良临床事件。此外,委员会认为, 我们应用我们实验室开发的先进的基于免疫的测定来询问分子和细胞, 动脉粥样硬化斑块的组成部分,扩展了我们最近的发现,即流感特异性T细胞在动脉粥样硬化斑块中发现。 动脉粥样硬化斑块,为了更好地了解最近临床 观察发现,患流感会增加心脏病发作和中风的风险。最后,我们将确定是否免疫 年龄有助于其他非传染性疾病,通过比较与 在我们的队列中使用公开可用的数据库将免疫状态与疾病联系起来, 可能性、严重性和预后。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Mark Morris Davis其他文献

Mark Morris Davis的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Mark Morris Davis', 18)}}的其他基金

Systems biological assessment of T cell responses to vaccination
T 细胞对疫苗接种反应的系统生物学评估
  • 批准号:
    10584571
  • 财政年份:
    2022
  • 资助金额:
    $ 63.87万
  • 项目类别:
Systems biological assessment of T cell responses to vaccination
T 细胞对疫苗接种反应的系统生物学评估
  • 批准号:
    10419280
  • 财政年份:
    2022
  • 资助金额:
    $ 63.87万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10190558
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
High resolution longitudinal immune monitoring for elucidating immune aging dynamics
高分辨率纵向免疫监测阐明免疫衰老动态
  • 批准号:
    10190557
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10687220
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
High resolution longitudinal immune monitoring for elucidating immune aging dynamics
高分辨率纵向免疫监测阐明免疫衰老动态
  • 批准号:
    10491673
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10491674
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
High resolution longitudinal immune monitoring for elucidating immune aging dynamics
高分辨率纵向免疫监测阐明免疫衰老动态
  • 批准号:
    10687219
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
Molecular interception and immunological characterization of age-associated disease
年龄相关疾病的分子拦截和免疫学表征
  • 批准号:
    10687228
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
Molecular interception and immunological characterization of age-associated disease
年龄相关疾病的分子拦截和免疫学表征
  • 批准号:
    10491684
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:

相似海外基金

Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
  • 批准号:
    495182
  • 财政年份:
    2023
  • 资助金额:
    $ 63.87万
  • 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
  • 批准号:
    2601817
  • 财政年份:
    2021
  • 资助金额:
    $ 63.87万
  • 项目类别:
    Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
  • 批准号:
    2029039
  • 财政年份:
    2020
  • 资助金额:
    $ 63.87万
  • 项目类别:
    Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
  • 批准号:
    9888417
  • 财政年份:
    2019
  • 资助金额:
    $ 63.87万
  • 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
  • 批准号:
    17K11318
  • 财政年份:
    2017
  • 资助金额:
    $ 63.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9320090
  • 财政年份:
    2017
  • 资助金额:
    $ 63.87万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    10166936
  • 财政年份:
    2017
  • 资助金额:
    $ 63.87万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9761593
  • 财政年份:
    2017
  • 资助金额:
    $ 63.87万
  • 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
  • 批准号:
    BB/M50306X/1
  • 财政年份:
    2014
  • 资助金额:
    $ 63.87万
  • 项目类别:
    Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
  • 批准号:
    288272
  • 财政年份:
    2013
  • 资助金额:
    $ 63.87万
  • 项目类别:
    Miscellaneous Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了