Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit

项目摘要/摘要 儿童败血症是导致死亡和发病的主要原因，但人们对其对身体的影响知之甚少。 出院后的功能。基于候选人之前的生物行为研究，这项建议 K99/R00的应用将利用症状科学方法来探索促炎的潜在作用 与脓毒症存活期危重儿童的身体功能有关的介质。这项建议 应用程序与国家护理研究所的使命很好地结合在一起，促进和改进 个人、家庭和社区的健康和生活质量。这款K99/R00的总体用途 应用，最大限度地增加科学和学术独立职业的机会(MOSAIC) 博士后职业转变促进多样性奖(PAR-19-343)，是为候选人 作为一名独立的护士科学家，拥有强大的儿科危重护理研究计划和 症状科学。在最初的指导阶段(K99)，候选人将利用现有数据来(A1)开发 在儿科重症监护病房(Persistent-PICU)接受脓毒症治疗后的儿童康复，a 多变量模型用于确定脓毒症存活期危重儿童的身体功能障碍风险。子目标 包括(a1.1)将危重儿童的病程与PICU出院后的身体功能联系起来； 以及(A1.2)将危重疾病期间的炎症对PICU出院后身体功能的作用联系起来。 候选人将通过先进的统计方法建立一个模型，以确定哪些儿童有患癌症的风险 PICU出院后的身体功能障碍。在独立阶段(R00)，候选人将进行 前瞻性纵向队列研究(A2)用新的生物学措施改进Persistent-PICU模型 发炎。脓毒症危重患儿术后有身体功能障碍风险的识别 出院后将为早期干预提供机会，以优化危重患者的身体功能 生病了。该奖项的指导阶段(K99)将包括由一个精心制作的、跨专业的 是炎症性疾病的拟议研究设计和高级生物统计建模方面的专家的科学家 儿科重症监护中的生物标志物。此外，候选人还提出了个性化培训计划，以 满足她独特的培训需求。培训计划包括参加马赛克UE5教育 会议、研讨会、科学会议和有针对性的课程。候选人的优秀导师团队， K99/R00应用程序中的定制研究计划和结果将为她过渡到 作为一名儿科重症监护和症状科学领域的护士科学家，具有独立性。

PROJECT SUMMARY/ABSTRACT Sepsis in children is a leading cause of death and morbidity, yet little is known about its impact on physical function after hospital discharge. Building upon the candidate’s prior biobehavioral research, this proposed K99/R00 application will utilize symptom science approaches to explore the potential role of pro-inflammatory mediators as they pertain to physical function in critically ill children who survive sepsis. This proposed application aligns well with the mission of the National Institute for Nursing Research, “to promote and improve the health and quality of life of individuals, families and communities.” The overall purpose of this K99/R00 application, Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (PAR-19-343), is to prepare the candidate for an independent career as a nurse scientist with a robust program of research in pediatric critical care and symptom science. In the initial mentored phase (K99), the candidate will utilize existing data to (A1) develop PEdiatric Recovery after sepSIS Treatment in the Pediatric Intensive Care Unit (PERSIST-PICU), a multivariable model to identify risk physical dysfunction risk in critically ill children who survive sepsis. Sub aims include (A1.1) associating the critically ill child’s course of illness with physical function after PICU discharge; and (A1.2) associating the role of inflammation during critical illness on physical function after PICU discharge. The candidate will develop a model through advanced statistical methods to identify children who are a-risk for physical dysfunction after PICU discharge. In the independent phase (R00), the candidate will conduct a prospective longitudinal cohort study to (A2) refine PERSIST-PICU model with new biological measures of inflammation. Identification of critically ill children with sepsis who are at-risk for physical dysfunction after discharge will provide an opportunity for early intervention to optimize their physical function after critical illness. The mentored phase of this award (K99) will include training by a well-crafted, interprofessional team of scientists who are experts in the proposed study design and advanced biostatistical modeling of inflammatory biomarkers in pediatric critical care. In addition, the candidate has proposed an individualized training plan to meet her unique training needs. The training plan includes attendance at the MOSAIC UE5 educational conference, seminars, scientific meetings and targeted coursework. The candidate’s stellar mentorship team, tailored research plan and findings within this K99/R00 application will prepare her well for transition to independence as a nurse scientist in pediatric critical care and symptom science.