Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit

儿科重症监护病房脓毒症治疗后的儿科康复

基本信息

  • 批准号:
    10688179
  • 负责人:
  • 金额:
    $ 24.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Sepsis in children is a leading cause of death and morbidity, yet little is known about its impact on physical function after hospital discharge. Building upon the candidate’s prior biobehavioral research, this proposed K99/R00 application will utilize symptom science approaches to explore the potential role of pro-inflammatory mediators as they pertain to physical function in critically ill children who survive sepsis. This proposed application aligns well with the mission of the National Institute for Nursing Research, “to promote and improve the health and quality of life of individuals, families and communities.” The overall purpose of this K99/R00 application, Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (PAR-19-343), is to prepare the candidate for an independent career as a nurse scientist with a robust program of research in pediatric critical care and symptom science. In the initial mentored phase (K99), the candidate will utilize existing data to (A1) develop PEdiatric Recovery after sepSIS Treatment in the Pediatric Intensive Care Unit (PERSIST-PICU), a multivariable model to identify risk physical dysfunction risk in critically ill children who survive sepsis. Sub aims include (A1.1) associating the critically ill child’s course of illness with physical function after PICU discharge; and (A1.2) associating the role of inflammation during critical illness on physical function after PICU discharge. The candidate will develop a model through advanced statistical methods to identify children who are a-risk for physical dysfunction after PICU discharge. In the independent phase (R00), the candidate will conduct a prospective longitudinal cohort study to (A2) refine PERSIST-PICU model with new biological measures of inflammation. Identification of critically ill children with sepsis who are at-risk for physical dysfunction after discharge will provide an opportunity for early intervention to optimize their physical function after critical illness. The mentored phase of this award (K99) will include training by a well-crafted, interprofessional team of scientists who are experts in the proposed study design and advanced biostatistical modeling of inflammatory biomarkers in pediatric critical care. In addition, the candidate has proposed an individualized training plan to meet her unique training needs. The training plan includes attendance at the MOSAIC UE5 educational conference, seminars, scientific meetings and targeted coursework. The candidate’s stellar mentorship team, tailored research plan and findings within this K99/R00 application will prepare her well for transition to independence as a nurse scientist in pediatric critical care and symptom science.
项目总结/摘要 脓毒症是儿童死亡和发病的主要原因,但对其对身体的影响知之甚少。 出院后的功能。基于候选人先前的生物行为研究,这一建议 K99/R 00应用程序将利用症状科学方法探索促炎因子的潜在作用。 介质,因为它们与脓毒症存活的危重儿童的身体功能有关。这一拟议 应用程序与国家护理研究所的使命非常一致,即“促进和改善 个人、家庭和社区的健康和生活质量”。本K99/R 00的总体目的 最大化科学和学术独立职业机会(MOSAIC) 博士后职业过渡奖,以促进多样性(PAR-19-343),是准备候选人的 作为一名护士科学家的独立职业生涯,在儿科重症监护方面有一个强大的研究计划, 症状科学在最初的指导阶段(K99),候选人将利用现有数据(A1)开发 儿科重症监护病房(PERSIST-PICU)中脓毒症治疗后的儿科恢复,a 多变量模型,以确定危险的身体功能障碍的危险重症儿童谁生存败血症。子目标 包括(A1.1)将危重患儿的病程与出院后的身体功能联系起来; 和(A1.2)将危重病期间的炎症对PICU出院后身体功能的作用联系起来。 候选人将通过先进的统计方法开发一个模型,以识别有患病风险的儿童 PICU出院后的身体功能障碍。在独立阶段(R 00),候选人将进行 前瞻性纵向队列研究,(A2)使用新的生物学指标完善PERSIST-PICU模型, 炎症脓毒症危重患儿的识别,这些患儿在接受治疗后有发生身体功能障碍的风险。 出院将提供早期干预的机会,以优化他们的身体功能, 病该奖项的指导阶段(K99)将包括由一个精心制作的跨专业团队进行培训, 在拟议的研究设计和炎症的先进生物统计建模方面的专家 儿科重症监护中的生物标志物。此外,候选人还提出了个性化的培训计划, 满足其独特的培训需求。培训计划包括参加MOSAIC UE 5教育 会议,研讨会,科学会议和有针对性的课程。候选人的明星导师团队, 在K99/R 00应用程序中定制的研究计划和研究结果将为她过渡到 作为儿科重症监护和症状科学的护士科学家的独立性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MALLORY A PERRY-EADDY其他文献

MALLORY A PERRY-EADDY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MALLORY A PERRY-EADDY', 18)}}的其他基金

Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit
儿科重症监护病房脓毒症治疗后的儿科康复
  • 批准号:
    10679122
  • 财政年份:
    2022
  • 资助金额:
    $ 24.9万
  • 项目类别:
Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit
儿科重症监护病房脓毒症治疗后的儿科康复
  • 批准号:
    10451762
  • 财政年份:
    2021
  • 资助金额:
    $ 24.9万
  • 项目类别:
Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit
儿科重症监护病房脓毒症治疗后的儿科康复
  • 批准号:
    10191080
  • 财政年份:
    2021
  • 资助金额:
    $ 24.9万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.9万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了