A critical role for rapid estrogen signaling in alcohol addiction and anxiety
快速雌激素信号在酒精成瘾和焦虑中的关键作用
基本信息
- 批准号:10190744
- 负责人:
- 金额:$ 46.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-10 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdoptedAlcohol consumptionAlcohol dependenceAlcohol withdrawal syndromeAlcoholsAmygdaloid structureAnatomyAnxietyAnxiety DisordersAutomobile DrivingBehaviorBehavior ControlBehavioralBehavioral MechanismsBiological AvailabilityBiosensorBrainCalciumCell NucleusCellsCorticotropin-Releasing HormoneDataDiseaseDoseDrug usageE211Electrophysiology (science)EstradiolEstrogen ReceptorsEstrogensEstrusExperimental DesignsFemaleFiberGlutamatesGonadal Steroid HormonesHormonesImageIn Situ HybridizationInterneuron functionLasersLeadMass Spectrum AnalysisMeasuresMembraneMenstrual cycleNeuronsNeuropeptidesOpticsOutputPeriodicityPeripheralPharmacologyPhenotypePhotometryPlayPopulationPreventionRNA InterferenceRecording of previous eventsResearchResolutionRiskRisk FactorsRoleSignal TransductionSliceSourceStressStructure of terminal stria nuclei of preoptic regionSynapsesTechnologyTimeWomanWorkaddictionalcohol comorbidityalcohol exposurealcohol use disorderbinge drinkingdrinkingdrinking behaviorexperimental studyin vivomalemennegative affectneural circuitneurophysiologyneuropsychiatric disordernovelnovel therapeutic interventionoptogeneticsreceptorreceptor bindingrecruitrelating to nervous systemreproductiveresponsesensorsexstress reactivitystressorsynaptic functiontooltransmission process
项目摘要
Project Summary/Abstract
Binge alcohol drinking and high stress reactivity are leading risk factors for anxiety and alcohol use disorders,
and women are at twice the risk for co-expression of these diseases. The sex hormone estrogen has been
implicated in playing a modulatory role in anxiety and alcohol/drug use and may be related to the telescoping
of addiction observed in women by amplifying the positive and negative components of binge alcohol
consumption and withdrawal. Further, alcohol consumption itself may be able to stimulate estrogen synthesis
to promote drinking behavior, suggesting that estrogen signaling may be an important mechanism in addiction
for both males and females. However, the mechanisms by which estrogen regulates neuronal function to
control these behaviors is unknown. We hypothesize that estrogen signals at membrane-bound receptors
located at discrete synaptic nodes of limbic circuitry to modulate their control of behavior, and that this
mechanism is prominent at baseline in females but becomes more important in males across alcohol drinking
exposure. In the proposed work, we examine the locus and mechanism of endogenous estrogen signaling, its
effect on circuit function and corresponding behavior, and alcohol-induced plasticity in estrogen modulation in
both males and females.
项目摘要/摘要
酗酒和高度应激反应是焦虑和酒精使用障碍的主要风险因素,
而女性同时患有这些疾病的风险是女性的两倍。性激素雌激素一直是
在焦虑和酒精/药物使用中起调节作用,并可能与伸缩有关
通过放大酗酒的积极和消极成分在女性中观察到的成瘾
消费和撤退。此外,饮酒本身可能会刺激雌激素的合成。
促进饮酒行为,提示雌激素信号可能是成瘾的重要机制
无论是男性还是女性。然而,雌激素调节神经功能的机制
控制这些行为是未知的。我们假设雌激素信号在膜结合受体上
位于边缘回路的离散突触节点,调节它们对行为的控制,这
这种机制在女性的基线上很突出,但在男性饮酒后变得更加重要
曝光。在拟议的工作中,我们研究了内源性雌激素信号转导的位置和机制,其
酒精对雌性大鼠神经回路功能和行为的影响及酒精诱导的可塑性
无论是雄性还是雌性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kristen Elizabeth Pleil其他文献
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{{ truncateString('Kristen Elizabeth Pleil', 18)}}的其他基金
A critical role for rapid estrogen signaling in alcohol addiction and anxiety
快速雌激素信号在酒精成瘾和焦虑中的关键作用
- 批准号:
10447201 - 财政年份:2019
- 资助金额:
$ 46.58万 - 项目类别:
The DNA methylation code governing the ensemble representation of morphine-context association
DNA甲基化密码控制吗啡-背景关联的整体表示
- 批准号:
9766748 - 财政年份:2019
- 资助金额:
$ 46.58万 - 项目类别:
A critical role for rapid estrogen signaling in alcohol addiction and anxiety
快速雌激素信号在酒精成瘾和焦虑中的关键作用
- 批准号:
10659024 - 财政年份:2019
- 资助金额:
$ 46.58万 - 项目类别:
The DNA methylation code governing the ensemble representation of morphine-context association
DNA甲基化密码控制吗啡-背景关联的整体表示
- 批准号:
9906873 - 财政年份:2019
- 资助金额:
$ 46.58万 - 项目类别:
A critical role for rapid estrogen signaling in alcohol addiction and anxiety
快速雌激素信号在酒精成瘾和焦虑中的关键作用
- 批准号:
10013109 - 财政年份:2019
- 资助金额:
$ 46.58万 - 项目类别:
The role of excitatory inputs to BNST CRF neurons in alcohol drinking behavior
BNST CRF 神经元兴奋性输入在饮酒行为中的作用
- 批准号:
8805040 - 财政年份:2015
- 资助金额:
$ 46.58万 - 项目类别:
The role of excitatory inputs to BNST CRF neurons in alcohol drinking behavior
BNST CRF 神经元兴奋性输入在饮酒行为中的作用
- 批准号:
9379322 - 财政年份:2015
- 资助金额:
$ 46.58万 - 项目类别:
The role of excitatory inputs to BNST CRF neurons in alcohol drinking behavior
BNST CRF 神经元兴奋性输入在饮酒行为中的作用
- 批准号:
9461824 - 财政年份:2015
- 资助金额:
$ 46.58万 - 项目类别:
The effect of alcohol drinking on NPY modulation of inhibition in the BNST
饮酒对 BNST 中 NPY 抑制调节的影响
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8469284 - 财政年份:2012
- 资助金额:
$ 46.58万 - 项目类别:
The effect of alcohol drinking on NPY modulation of inhibition in the BNST
饮酒对 BNST 中 NPY 抑制调节的影响
- 批准号:
8314809 - 财政年份:2012
- 资助金额:
$ 46.58万 - 项目类别:
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