A naturalistic visual task for studying distance estimation in the mouse
A naturalistic visual task for studying distance estimation in the mouse
批准号:
10196738
负责人:
Cristopher M Niell
金额:
$21.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-07-01 至 2023-06-30
关键词:
AddressAnimalsAreaBehavioralBinocular VisionBrainBrain regionComputer ModelsCuesDepth PerceptionDissectionDistantEnvironmentEyeFoundationsFutureGerbilsHeadHead MovementsHumanImageImpairmentLesionMeasuresMediatingMethodsModelingMonocular VisionMotionMotion PerceptionMotorMotor CortexMovementMusNatureNeuronsPerformancePositioning AttributePraying MantisPreoptic AreasPrevalenceProcessRattusResearchRetinaRewardsRodentRoleSensorySignal TransductionStimulusTestingTranslationsVisionVision DisordersVision DisparityVisualVisual CortexVisual PerceptionVisual system structureWidthWorkactive visionarea striatabasebrain pathwaycell typedetectorexperimental studygazeinnovationinsightneural circuitneuromechanismoptogeneticspreventrelating to nervous systemretinal imagingsuperior colliculus Corpora quadrigeminavisual tracking
中文摘要
项目摘要
视觉通过提供有关环境的感官信息,
例如到相关对象的距离。视觉感知的一个关键特征是积极探索
通过眼睛、头部和身体的平移来呈现视觉场景。视觉皮层被认为
联合收割机将这些自发的运动信号与视觉输入结合起来,
环境保护虽然最近的研究表明,小鼠V1神经元中有很大一部分
编码运动信息,而不是简单地充当视觉特征检测器,V1功能模型
在很大程度上忽略了运动传出和感觉传入的贡献。我们的目的是阐明
从运动视差研究深度知觉的神经机制
基本的视觉计算,结合观察者的自我运动和视网膜图像位移,
计算到环境中物体的距离。
我们将首先调整行为学,自由移动沙鼠/大鼠距离估计任务,以小鼠,
确定老鼠在跳过缝隙时用来测量深度的视觉线索的类型。然后我们将
操纵视觉皮层的活动及其来自大脑区域的传递运动相关信息的输入
信号,以测试它们在运动视差距离估计中的作用。的
在R21应用中提出的实验为神经系统的未来研究提供了基础。
电路级,以确定视觉和运动信号是如何集成的计算,
距离估计,特别是在自然环境中。
英文摘要
PROJECT SUMMARY
Vision facilitates navigation through the world by providing sensory information about the environment,
such as the distance to relevant objects. A key feature of visual perception is the active exploration of
the visual scene through translation of the eyes, head, and body. Visual cortex has been proposed to
combine these self-generated motor signals with visual input to compute information about objects in
the environment. While recent studies have shown that a significant fraction of neurons in mouse V1
encode movement information and do not simply act as visual feature detectors, models of V1 function
have largely ignored motor efference and sensory reafferent contributions. We aim to elucidate the
neural mechanisms underlying active vision by investigating depth perception from motion parallax - a
fundamental visual computation that combines observer self-motion and retinal image displacement to
calculate the distance to objects in the environment.
We will first adapt an ethological, freely-moving gerbil/rat distance estimation task to mice in order to
determine the types of visual cues mice use to gauge depth when jumping across a gap. We will then
manipulate the activity of visual cortex and its inputs from brain regions conveying movement-related
signals, in order to test their roles specifically in distance estimation from motion parallax. The
experiments proposed in this R21 application provide the foundation for future studies at the neural
circuit level, to determine how visual and movement signals are integrated for computations such as
distance estimation, particularly in a natural context.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The interaction of cortical and subcortical processing in natural sensory behavior
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批准号:10455297
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项目类别:
-
资助金额:$169.07万
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财政年份:2022
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负责人:Cristopher M Niell
-
依托单位:
Navigating Educational Trajectories in Neuroscience
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批准号:10656153
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项目类别:
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资助金额:$25.76万
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财政年份:2022
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负责人:Cristopher M Niell
-
依托单位:
A naturalistic visual task for studying distance estimation
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批准号:10415984
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项目类别:
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资助金额:$17.16万
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财政年份:2021
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负责人:Cristopher M Niell
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依托单位:
Neural coding and functional organization of the octopus visual system
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批准号:10310780
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项目类别:
-
资助金额:$13.73万
-
财政年份:2021
-
负责人:Cristopher M Niell
-
依托单位:
Neural coding and functional organization of the octopus visual system
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批准号:10053626
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项目类别:
-
资助金额:$106.38万
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财政年份:2020
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负责人:Cristopher M Niell
-
依托单位:
Neural coding and functional organization of the octopus visual system
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批准号:10709768
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项目类别:
-
资助金额:$36.56万
-
财政年份:2020
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负责人:Cristopher M Niell
-
依托单位:
Neural pathways and behavioral state in the visual system
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批准号:9251289
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项目类别:
-
资助金额:$35.63万
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财政年份:2013
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负责人:Cristopher M Niell
-
依托单位:
Neural pathways and behavioral state in the mouse visual system
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批准号:8481290
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项目类别:
-
资助金额:$35.63万
-
财政年份:2013
-
负责人:Cristopher M Niell
-
依托单位:
Neural pathways and behavioral state in the visual system
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批准号:8651495
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项目类别:
-
资助金额:$34.91万
-
财政年份:2013
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负责人:Cristopher M Niell
-
依托单位:
Connecting developmental mechanisms to visual function and perception
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批准号:8358286
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项目类别:
-
资助金额:$217.5万
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财政年份:2012
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负责人:Cristopher M Niell
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依托单位:
Development of connectivity in mouse visual cortex
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批准号:6999674
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项目类别:
-
资助金额:$4.4万
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财政年份:2005
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负责人:Cristopher M Niell
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依托单位:
海外基金