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Neural coding and functional organization of the octopus visual system

章鱼视觉系统的神经编码和功能组织

基本信息

批准号：
10310780
负责人：
Cristopher M Niell
金额：
$ 13.73万
依托单位：
UNIVERSITY OF OREGON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2023-05-31
项目状态：
已结题

项目摘要

Abstract Cephalopods have large and complex brains, and in particularly a highly capable visual system. However, their brains evolved independently from vertebrates, and very little is known about how neural circuits in the cephalopod brain process visual information. In fact, there has never been a direct recording of receptive fields in the central visual system of cephalopods. This study will measure neural activity and visual coding in the optic lobe of Octopus bimaculoides, an emerging model organism for cephalopod research. The first aim will employ two-photon calcium imaging in the optic lobe of juvenile octopuses, combined with controlled visual stimuli, to measure receptive field properties in large ensembles of individual neurons. The second aim will combine this functional imaging with anatomical connectivity, identified via retrograde tracing, to determine how visual information is routed through the visual system and into higher brain regions associated with specific behaviors. The third aim will incorporate these experimental results into computational analysis of the visual features being encoded, and into network models of visual processing. Together, these aims will provide direct insight into the neural coding and functional organization of this unique visual system. This project will be the first to describe neural computations in the central visual system of cephalopods. Examination of a system that is evolutionarily distinct, yet functionally parallel to the vertebrate system, has the potential to illuminate novel ways by which visual processing can be carried out. Likewise, observation of convergence of functional organization in cephalopods, relative to vertebrates and other invertebrates such as Drosophila, would help identify key features necessary for the function of complex visual systems. In this diversity supplement, we request funding for Ms. Jeremea Songco, a graduate student in the Niell lab, to perform additional characterization of the anatomical organization of the optic lobe. This will extend the characterization proposed in Aim 2, to include cell types defined by transcriptional analysis. In additional to broadening the research impact of this project, this supplement will provide key training for Ms. Songco in visual processing, quantitative data analysis, and scientific communication.

摘要

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cell types and molecular architecture of the Octopus bimaculoides visual system.

DOI：
10.1016/j.cub.2022.10.015
发表时间：
2022-12-05
期刊：
CURRENT BIOLOGY
影响因子：
9.2
作者：
Songco-Casey, Jeremea O.;Coffing, Gabrielle C.;Piscopo, Denise M.;Pungor, Judit R.;Kern, Andrew D.;Miller, Adam C.;Niell, Cristopher M.
通讯作者：
Niell, Cristopher M.

Cephalopod Sex Determination and its Ancient Evolutionary Origin Revealed by Chromosome-level Assembly of the California Two-Spot Octopus.

加州两点章鱼的染色体水平组装揭示了头足类动物的性别决定及其古代进化起源。

DOI：
10.1101/2024.02.21.581452
发表时间：
2024
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Coffing,GabrielleC;Tittes,Silas;Small,ScottT;Songco-Casey,JeremeaO;Piscopo,DeniseM;Pungor,JuditR;Miller,AdamC;Niell,CristopherM;Kern,AndrewD
通讯作者：
Kern,AndrewD

Functional organization of visual responses in the octopus optic lobe.

章鱼视叶视觉反应的功能组织。