Woodsmoke-induced disruption of Nasal Microbiome and Cytokine Profiles
木烟引起的鼻微生物组和细胞因子谱的破坏
基本信息
- 批准号:10196055
- 负责人:
- 金额:$ 15.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAir PollutantsAir PollutionAllergicAllergic rhinitisAntigensAsthmaBioinformaticsBiological Response ModifiersBiomassBuffersCause of DeathCellsCigaretteCoronavirusCross-Over StudiesDataDiseaseDoseEcosystemElectronic cigaretteEnzyme-Linked Immunosorbent AssayEpidemiologyEpithelial CellsExposure toFeedbackFoundationsFutureHomeostasisHost DefenseHourImmuneImmune responseImmune systemImmunologicsIncidenceIndividualInflammationInflammatoryInfluenzaInhalationInhalation ExposureIntestinal MucosaKnowledgeLaboratoriesLeadLinkLiquid substanceLung diseasesMediatingMicrobeModelingMucosal Immune ResponsesMucositisMucous MembraneNasal EpitheliumNoseParticulate MatterPathway AnalysisPlacebosPopulationPredispositionPreventionProcessProteinsPublic HealthRandomizedResearch DesignRespiration DisordersRespiratory MucosaRespiratory SystemRespiratory Tract InfectionsRoleSamplingSignal TransductionSmokeSmokingSourceSputumStatistical Data InterpretationStructure of mucous membrane of noseSystemTimeTissuesViralWildfireWorkair filterambient air pollutionasthmaticbeta diversitychemokinecigarette smokecommensal bacteriacytokinedysbiosisexposed human populationgut microbiomehost microbiotahuman subjectimmunoregulationinfluenzavirusmicrobialmicrobial colonizationmicrobiomemicrobiotamicroorganismnasal microbiomenovelparticleparticle exposurepathogenpollutantpublic health relevanceresident commensalsrespiratoryrespiratory disease/disorder therapyrespiratory healthrespiratory microbiomerespiratory pathogenresponsesextherapy developmentwood smoke
项目摘要
ABSTRACT
Global exposure to woodsmoke particles, primarily from wildfires and biomass burning, are an ever-increasing source of
particulate matter, which is linked to many respiratory conditions. Successful defense against woodsmoke requires
proficient immune regulation to maintain overall homeostasis. Critical to establishing an effective immune response to
inhaled antigens, the nasal mucosa are known to be colonized by a large number of fungal, bacterial and viral micro-
organisms. Disorders of the respiratory tract, however, are considered diseases of inflammation, not infection. Many studies
have shown the role of commensal resident microbes and their metabolites in the initiation and/or progression of mucosal
inflammation. For instance, incidence of allergic and inflammatory disease, including asthma and allergic rhinitis, is
associated with a lack of diverse microbial colonization. Nasal cytokines are also known to be altered in those exposed to
air pollutants (e.g., wildfire smoke), and to alter the robustness of response to viral insults, such as influenza and
coronaviruses. Thus, we hypothesize that wood smoke exposure induces dysbiosis of the nasal microbiome and an altered
inflammatory cytokine profile, which together have implications for respiratory health. We address this gap by identifying
how concurrent microbiota and cytokine profiles change in response to exposure to woodsmoke. In this crossover
study design, we will collect nasal epithelial lining fluid samples from healthy individuals at multiple time points post-
exposure to either woodsmoke or filtered air in a controlled setting, in order to generate microbiome and the cytokine
profiles. Once samples have been processed in the laboratory, we will conduct bioinformatic and statistical analyses to
describe how acutely the microbiome and cytokines are concurrently altered in response to woodsmoke. We will also
compare baseline profiles and responses in microbiome and cytokine responses by demographic and other factors. While
we focus here on a woodsmoke exposure, this work has diverse applications including for future studies of atopic disease,
ambient air pollution exposure, smoking; and potential development of therapies for respiratory disease.
抽象的
全球暴露于主要来自野火和生物质燃烧的木烟颗粒是一个不断增加的来源
颗粒物,与许多呼吸系统疾病有关。成功防御木烟需要
熟练的免疫调节以维持整体稳态。对于建立有效的免疫反应至关重要
吸入抗原后,已知鼻粘膜定植有大量真菌、细菌和病毒微生物。
有机体。然而,呼吸道疾病被认为是炎症疾病,而不是感染疾病。许多研究
已经表明共生微生物及其代谢物在粘膜炎症的发生和/或进展中的作用
炎。例如,过敏性和炎症性疾病(包括哮喘和过敏性鼻炎)的发病率
与缺乏多样化的微生物定植有关。众所周知,暴露于以下环境的人的鼻细胞因子也会发生改变:
空气污染物(例如野火烟雾),并改变对病毒侵害(例如流感和流感)的反应稳健性
冠状病毒。因此,我们假设暴露于木烟会导致鼻腔微生物群失调,并改变鼻腔微生物群的结构。
炎症细胞因子谱,它们共同对呼吸系统健康产生影响。我们通过确定来解决这一差距
同时发生的微生物群和细胞因子谱如何因暴露于木烟而发生变化。在这个跨界
在研究设计中,我们将在术后多个时间点从健康个体收集鼻上皮衬里液体样本
在受控环境下暴露于木烟或过滤空气中,以产生微生物组和细胞因子
配置文件。一旦样品在实验室处理完毕,我们将进行生物信息和统计分析,以
描述微生物组和细胞因子因木烟而同时发生变化的剧烈程度。我们还将
按人口统计和其他因素比较微生物组和细胞因子反应的基线概况和反应。尽管
我们在这里关注的是木烟暴露,这项工作有多种应用,包括未来对特应性疾病的研究,
暴露于环境空气污染、吸烟;以及呼吸系统疾病疗法的潜在发展。
项目成果
期刊论文数量(0)
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Radhika Dhingra其他文献
Radhika Dhingra的其他文献
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{{ truncateString('Radhika Dhingra', 18)}}的其他基金
Woodsmoke-induced disruption of Nasal Microbiome and Cytokine Profiles
木烟引起的鼻微生物组和细胞因子谱的破坏
- 批准号:
10375584 - 财政年份:2021
- 资助金额:
$ 15.55万 - 项目类别:
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