Evolution of environmental regulation of cell states in animal life cycles
Evolution of environmental regulation of cell states in animal life cycles
批准号:
DP210100703
负责人:
Prof Bernard Degnan
金额:
$51.68万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2021
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2021-10-01 至 2024-09-30
中文摘要
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英文摘要
This project seeks to understand how the environment influences the fate of cells over an animal's life, and how this influence originated in animal evolution. Using a homegrown Australian model, a sea sponge from the Great Barrier Reef, and advanced multi-omic approaches (genomics plus cell biology), this project aims to uncover the mechanisms underlying global cell state changes that are induced through the interplay of environmental and endogenous signals at metamorphosis. Because of the evolutionary position of sponges, outcomes of this project expect to reveal the cardinal rules governing environmentally-induced cell state changes that are obligatory for most animals to complete their complex life cycles.
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