Evolution of environmental regulation of cell states in animal life cycles

动物生命周期中细胞状态环境调节的演变

• 批准号: DP210100703
• 负责人: Prof Bernard Degnan
• 金额: $ 51.68万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100703
• 关键词: Evolution; environmental; regulation; cell; states

This project seeks to understand how the environment influences the fate of cells over an animal's life, and how this influence originated in animal evolution. Using a homegrown Australian model, a sea sponge from the Great Barrier Reef, and advanced multi-omic approaches (genomics plus cell biology), this project aims to uncover the mechanisms underlying global cell state changes that are induced through the interplay of environmental and endogenous signals at metamorphosis. Because of the evolutionary position of sponges, outcomes of this project expect to reveal the cardinal rules governing environmentally-induced cell state changes that are obligatory for most animals to complete their complex life cycles.

该项目旨在了解环境如何影响动物一生中细胞的命运，以及这种影响如何起源于动物进化。利用澳大利亚本土的模型，大堡礁的海绵和先进的多组学方法（基因组学加细胞生物学），该项目旨在揭示通过变态时环境和内源性信号的相互作用引起的全球细胞状态变化的机制。由于海绵的进化地位，该项目的成果有望揭示环境诱导的细胞状态变化的基本规则，这些变化是大多数动物完成复杂生命周期所必需的。