Inflammation and gynecologic cancer: the role of prostaglandins in ovarian cancer

炎症与妇科癌症：前列腺素在卵巢癌中的作用

• 批准号: 10196979
• 负责人: Mollie Elyse Barnard
• 金额: $ 11.42万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-18 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10196979
• 关键词: Address; Adult; Age; Area; Award; Big Data; Biological Markers; Cancer Etiology; Carcinogenesis Mechanism; Characteristics; Chemoprevention; Chemopreventive Agent; Complex; Data; Development; Diagnosis; Dinoprostone; Disease; Dose; Drug Exposure; Drug usage; Early Diagnosis; Endometrial Carcinoma; Environment; Epidemiology; Etiology; Evaluation; Exposure to; Fellowship; Foundations; Frequencies; Gene Expression; Goals; Grant; Immunity; Individual; Inflammation; Inflammatory; Influentials; Interdisciplinary Study; Knowledge; Life; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of ovary; Mentors; Molecular Epidemiology; Non-Steroidal Anti-Inflammatory Agents; Nurses' Health Study; Ovarian; Ovary; Ovulation; Pathway interactions; Pattern; Play; Postdoctoral Fellow; Postmenopause; Premenopause; Prevention; Prevention strategy; Productivity; Prostaglandins; Protocols documentation; Public Health Schools; Questionnaires; Reactive Oxygen Species; Recommendation; Reporting; Research; Research Project Grants; Research Training; Risk; Risk Factors; Role; Secure; Serous; Stains; Statistical Methods; Tissue Microarray; Tissues; Training; Tumor Pathology; Tumor Subtype; Tumor-associated macrophages; Woman; Work; Writing; cancer epidemiology; cancer risk; cancer site; carcinogenesis; career; cytokine; density; detection method; epidemiology study; experience; improved; inflammatory marker; innovation; metabolomics; modifiable risk; mortality; novel; novel marker; ovarian cancer prevention; ovarian neoplasm; overexpression; post-doctoral training; pre-doctoral; programs; prospective; skills; success; tumor; tumorigenesis; urinary; wound healing

PROJECT SUMMARY/ABSTRACT My ultimate goal is to become a leader in the field of cancer epidemiology who conducts innovative and high-impact research on the etiology and prevention of gynecologic cancers. Ovarian cancer is the most fatal gynecologic malignancy; despite advances in treatment, five-year survival is only 44%. The primary goal of my dissertation research is to improve ovarian cancer prevention by understanding the role of inflammation and immunity in ovarian tumor development, with a specific focus on prostaglandins. My research will leverage longitudinal questionnaire, biomarker, and tissue data from the Nurses’ Health Studies to determine how prediagnostic prostaglandin levels and long-term patterns of adult NSAID use are associated with risk of ovarian cancer. First, I will determine whether prediagnostic levels of urinary prostaglandin metabolite PGE-M are associated with risk of ovarian cancer. Second, using a lifecourse approach, I will evaluate the relationships of premenopausal and postmenopausal NSAID use with risk of ovarian cancer, considering timing, frequency, and duration of use. Third, since ovarian cancer is a highly heterogeneous disease, my proposed research will determine whether the association between NSAID use and risk of ovarian cancer differs by tumor aggressiveness or by density of tumor-associated macrophages, which are stimulated by prostaglandins. The results of this project will clarify if exposure to prostaglandins influences risk of ovarian cancer, and will provide information on the timing, frequency and duration of NSAID use that is most likely to be chemopreventive. As a postdoctoral fellow I will leverage my predoctoral training in the analysis of complex epidemiologic exposure data, ovarian tumor pathology, and biomarker research, while expanding my research to include the analysis of metabolomic and gene expression data. This training will allow me to better identify novel biomarkers and pathways in cancer etiology. Further, I will broaden my research focus to include the etiology of endometrial cancer. With this additional expertise, a growing network of collaborators, and training in grant writing, I will be well prepared to develop an innovative, multidisciplinary research program in cancer epidemiology.

项目总结/文摘

项目成果

Aspirin Use and the Risk of Cancer-In Reply.

阿司匹林的使用和癌症风险-回复。

• DOI: 10.1001/jamaoncol.2019.0633
• 发表时间: 2019
• 期刊: JAMA oncology
• 影响因子: 28.4
• 作者: Simon,TraceyG;Barnard,MollieE;Chan,AndrewT
• 通讯作者: Chan,AndrewT

Impact of age, race, and family history on COVID-19-related changes in breast cancer screening among the Boston mammography cohort study.

波士顿乳房 X 线摄影队列研究中，年龄、种族和家族史对乳腺癌筛查中与 COVID-19 相关的变化的影响。

• DOI: 10.1007/s10549-023-07083-y
• 发表时间: 2023
• 期刊: Breast cancer research and treatment
• 影响因子: 3.8
• 作者: Chen,Naiyu;Cheng,David;Sodipo,MichelleO;Barnard,MollieE;DuPre,NatalieC;Tamimi,RullaM;Warner,EricaT
• 通讯作者: Warner,EricaT