Clinical and Translational Core

临床和转化核心

基本信息

  • 批准号:
    10197906
  • 负责人:
  • 金额:
    $ 21.48万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-15 至 2022-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary / Abstract: Clinical & Translational Core (CTC) The goal of the Stanford Clinical & Translational Core (CTC) is to facilitate high-impact diabetes research by SDRC members. At Stanford, pioneers in cutting-edge technologies of diverse science fields are often in search of clinical collaborators with human subjects to `translate' their findings to the clinic. Similarly, clinical investigators often fail to innovate based on a lack of awareness or accessibility to improved or novel methodologies. In addition, teams of scientists and clinicians attempting to translate their work often encounter hurdles with regulatory processes, recruitment/retention, sample management, and thoughtful data collection, leading to inefficient use of time, sample loss, failure to complete studies, and disincentive to provide banked samples for collaborators. The CTC will address these specific needs by leveraging existing Stanford resources to focus on diabetes-specific research, thus enhancing our institution's ability to perform innovative high-impact interdisciplinary studies that surpass the capabilities of a single investigator/laboratory. An online survey revealed that 76% of SDRC investigators intend to use the CTC. The CTC will be led by a team of directors that are national leaders in their fields of diabetes-related research: Drs. Gardner, McLaughlin and Desai. The CTC will develop and provide three core services: 1) A biorepository of existing and prospectively collected samples with standardization of collection and sample tracking, and links to clinical data, all accessible via a centralized hub; 2) Advanced support in analytics including study design, database design with setup of data capture in REDCap and linkage to the electronic medical record and biorepository, data management, and data analysis, and 3) Clinical trial support that includes the creation of a Clinical Registry for recruitment, and guidance in the logistics and conduct of trials, as well as for maximizing retention and compliance. 4) The CTC will orient SDRC investigators and their teams and train them to use each of these core services effectively. The CTC will provide access to innovative methodologies and computer-based systems for designing studies, recording data, logging samples, and linking sample results to phenotypic and metabolic data. The Stanford CTC will leverage expertise in scientific methods and research-support systems developed on campus but that are underused or not yet tailored to diabetes research. Institution-wide support exists for collaborative and “team” science, for modernizing data collection methods, and for resource sharing. Use of the CTC by SDRC members will advance the planning, execution and communication of coordinated, collaborative, and transformative clinical and translational research.
项目摘要/摘要:临床和转化核心(CTC) 斯坦福大学临床与转化核心(CTC)的目标是通过以下方式促进高影响力的糖尿病研究: SDRC成员。在斯坦福大学,不同科学领域尖端技术的先驱们经常在 寻找与人类受试者的临床合作者,将他们的发现“翻译”到临床。同样,临床 调查人员往往未能创新的基础上缺乏认识或可访问性,以改善或新颖的 方法论。此外,科学家和临床医生团队试图翻译他们的工作经常遇到 监管流程、招募/保留、样本管理和周到的数据收集方面的障碍, 导致时间利用效率低下、样本损失、无法完成研究,以及不鼓励提供库存 合作者的样本。气候技术中心将利用现有的斯坦福大学 资源集中在糖尿病的具体研究,从而提高我们的机构的能力,进行创新 高影响力的跨学科研究,超越了单一研究者/实验室的能力。一个在线 调查显示,76%的SDRC调查人员打算使用CTC。 CTC将由糖尿病相关研究领域的国家领导人组成的董事团队领导: Drs.加德纳,麦克劳克林和德赛。CTC将开发和提供三项核心服务: 现有和预期采集样品的生物储存库,采集和样品标准化 跟踪和链接到临床数据,所有这些都可通过集中式中心访问; 2)分析方面的高级支持 包括研究设计、数据库设计,在REDCap中设置数据采集并与电子 医疗记录和生物储存库、数据管理和数据分析,以及3)临床试验支持, 包括创建临床登记处以进行招募,并指导试验的后勤和实施, 以及用于最大化保留和顺应性。4)CTC将指导SDRC调查人员及其 团队,并培训他们有效地使用这些核心服务。 气候技术中心将为设计研究提供创新方法和计算机系统, 记录数据、记录样品并将样品结果与表型和代谢数据相关联。斯坦福大学 CTC将利用校园内开发的科学方法和研究支持系统的专业知识, 未被充分利用或尚未针对糖尿病研究进行调整。全机构支持协作和 “团队”科学,使数据收集方法现代化和资源共享。SDRC使用CTC 成员将推进协调、协作和 变革性临床和转化研究。

项目成果

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CHRISTOPHER D GARDNER其他文献

CHRISTOPHER D GARDNER的其他文献

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{{ truncateString('CHRISTOPHER D GARDNER', 18)}}的其他基金

Cardiovascular and Chronic Disease Prevention Training Program
心血管及慢性病预防培训计划
  • 批准号:
    10576305
  • 财政年份:
    2022
  • 资助金额:
    $ 21.48万
  • 项目类别:
Cardiovascular and Chronic Disease Prevention Training Program
心血管及慢性病预防培训计划
  • 批准号:
    10347666
  • 财政年份:
    2022
  • 资助金额:
    $ 21.48万
  • 项目类别:
Do Genotype Patterns Predict Weight Loss Success for Low Carb vs. Low Fat Diets?
基因型模式是否可以预测低碳水化合物与低脂肪饮食的减肥成功?
  • 批准号:
    8723168
  • 财政年份:
    2012
  • 资助金额:
    $ 21.48万
  • 项目类别:
Do Genotype Patterns Predict Weight Loss Success for Low Carb vs. Low Fat Diets?
基因型模式是否可以预测低碳水化合物与低脂肪饮食的减肥成功?
  • 批准号:
    8238015
  • 财政年份:
    2012
  • 资助金额:
    $ 21.48万
  • 项目类别:
Do Genotype Patterns Predict Weight Loss Success for Low Carb vs. Low Fat Diets?
基因型模式是否可以预测低碳水化合物与低脂肪饮食的减肥成功?
  • 批准号:
    9130922
  • 财政年份:
    2012
  • 资助金额:
    $ 21.48万
  • 项目类别:
Do Genotype Patterns Predict Weight Loss Success for Low Carb vs. Low Fat Diets?
基因型模式是否可以预测低碳水化合物与低脂肪饮食的减肥成功?
  • 批准号:
    8545170
  • 财政年份:
    2012
  • 资助金额:
    $ 21.48万
  • 项目类别:
Do Genotype Patterns Predict Weight Loss Success for Low Carb vs. Low Fat Diets?
基因型模式是否可以预测低碳水化合物与低脂肪饮食的减肥成功?
  • 批准号:
    8912454
  • 财政年份:
    2012
  • 资助金额:
    $ 21.48万
  • 项目类别:
Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
GSH /-精氨酸对有 CVD 风险的成年人炎症标志物的影响
  • 批准号:
    7931999
  • 财政年份:
    2009
  • 资助金额:
    $ 21.48万
  • 项目类别:
Adding Sleep Intervention to Traditional Exercise & Diet Approach to Weight Loss
在传统锻炼中添加睡眠干预
  • 批准号:
    7763911
  • 财政年份:
    2009
  • 资助金额:
    $ 21.48万
  • 项目类别:
Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
GSH /-精氨酸对有 CVD 风险的成年人炎症标志物的影响
  • 批准号:
    7739875
  • 财政年份:
    2009
  • 资助金额:
    $ 21.48万
  • 项目类别:

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