SWG1: HIV/TB Scientific Working Group

项目摘要/摘要 普罗维登斯/波士顿(P/B)CFAR的艾滋病毒-结核病科学工作组(SWG)成立于#年 2017年1月，并建立在布朗/LIFESPAN和北大艾滋病毒的互补科学专业知识基础上 和结核病(TB)研究小组及其国内和国际站点，以便了解 艾滋病毒和结核病及其各自的全球流行的双向影响。目前，关于结核病和艾滋病毒/结核病的研究 占P/B CFAR资助研究基地(FRB)的主要组成部分。有独一无二的 P/B CFAR艾滋病毒-结核病工作组有机会在三个领域开展创新研究：第一，调整重点 关于结核病的研究，以纳入艾滋病毒/结核病，解决与艾滋病毒及其自然病史有关的问题 发病机制；第二，将生物成分引入目前主要是临床和/或研究的研究 第三，吸引初级和高级研究人员进入该领域。P/B CFAR已承诺采取 通过创建这个艾滋病毒-结核病特别工作组，利用这些机会。 SWG将把目前正在研究艾滋病毒/结核病问题的调查人员与目前没有研究艾滋病毒/结核病问题的调查人员聚集在一起 参与这项研究，以分享想法并确定其目前资助的项目中潜在的子研究， 以及潜在的新项目。这将通过每两个月举行一次的午餐会议来完成，在布朗和布朗之间交替举行 和BU，CFAR赞助的年度结核病会议，SWG执行委员会将每半年举行一次会议，以 审查对这些活动的参与情况，并评估这些活动是否导致预期的结果和产出。 此外，SWG将通过将其他P/B CFAR核心的专业知识应用于 解决SWG的具体目标。因此，SWG将通过促进新的 以及通过最大限度地提高CFAR核心的生产力。

Project Summary/Abstract The Providence/Boston (P/B) CFAR's HIV-TB Scientific Working Group (SWG) was established in January 2017, and has built on the complementary scientific expertise of the Brown/Lifespan and BUMC HIV and tuberculosis (TB) research groups, and their domestic and international sites, in order to understand the bidirectional effects of HIV and TB and their respective global epidemics. Currently, research on TB and HIV/TB accounts for a major component of the funded research base (FRB) of the P/B CFAR. There are unique opportunities for the P/B CFAR HIV-TB SWG to develop innovative research in three areas: first, to refocus research on TB to incorporate HIV/TB, addressing issues pertaining to the natural history of HIV and its pathogenesis; second, to introduce biologic components to research that is at this point primarily clinical and/or behavioral; and third, to attract junior and senior researchers to the field. The P/B CFAR has committed to take advantage of these opportunities by creating this HIV-TB SWG. The SWG will bring together investigators currently working on HIV/TB issues with those not currently involved in this research to share ideas and identify potential sub-studies within their currently funded projects, as well as potential new projects. This will be done via bi-monthly lunch meetings, alternating between Brown and BU, annual CFAR sponsored TB meetings, and the SWG Executive Committee will meet semiannually to review participation in these activities and assess whether they are leading to the desired outcomes and outputs. In addition, the SWG will add to the productivity of the other P/B CFAR Cores by applying their expertise to addressing the SWG Specific Aims. Thus, the SWG will add value both by facilitating the development of new and innovative projects as well as by maximizing the productivity of the CFAR Cores.