A New Model of Gestational Cannabis Exposure

妊娠期大麻暴露的新模式

基本信息

项目摘要

Summary The use of cannabis during pregnancy have dramatically increased during the last ten years. While the effects of cannabis and its components on brain development are poorly known, recent studies have observed frequent mental health problems in the offspring of mothers that used marijuana during gestation. During the third trimester of human gestation the brain undergoes a “growth spurt” that is characterized by an intensive process of synaptogenesis. This stage is followed by a period of refinement by activity-dependent neuronal plasticity where synapses reaching “correct targets” are strengthened whereas synapses reaching “incorrect targets” are pruned. The exposure to drugs and certain medications during this period have the potential to alter these processes, resulting in multiple neurobehavioral problems. It has been demonstrated in humans and animal models that developmental THC exposure reduces the expression of CB1r. In layer 2/3 of the visual cortex endocannabinoid neurotransmission is essential for the expression of iLTD and for the developmental transition between high to low GABA release probability characteristic of mature inhibitory cells in this region. Proper levels of inhibition are essential for the ocular dominance plasticity and the establishment of neuronal circuits responsible for neuronal orientation tuning and formation of orientation selectivity columns. Based on this scientific premise we hypothesize that THC exposure during the third trimester equivalent of human gestation leads to persistent reduction in endocannabinoid transmission, resulting in an impairment in iLTD and preventing maturation of inhibition. As a consequence, both ocular dominance plasticity and orientation selectivity would be impaired. Here we will use a combination of in vivo and ex vivo electrophysiology and optical imaging of intrinsic signals to test this hypothesis. The accomplishment of these experiments would result in the development of a novel model of prenatal exposure to cannabis that could be used to investigate mechanisms of action of gestational marijuana and potential interventions.
总结

项目成果

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Alexandre Esteves Medina其他文献

Alexandre Esteves Medina的其他文献

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{{ truncateString('Alexandre Esteves Medina', 18)}}的其他基金

A novel animal model to study the association between alcohol abuse during late adolescence with common conditions observed in combat Veterans
一种新的动物模型,用于研究青春期后期酗酒与退伍军人中观察到的常见状况之间的关联
  • 批准号:
    10644999
  • 财政年份:
    2022
  • 资助金额:
    $ 23.18万
  • 项目类别:
A novel animal model to study the association between alcohol abuse during late adolescence with common conditions observed in combat Veterans
一种新的动物模型,用于研究青春期后期酗酒与退伍军人中观察到的常见状况之间的关联
  • 批准号:
    10368295
  • 财政年份:
    2022
  • 资助金额:
    $ 23.18万
  • 项目类别:
A New Model of Gestational Cannabis Exposure
妊娠期大麻暴露的新模式
  • 批准号:
    10447141
  • 财政年份:
    2021
  • 资助金额:
    $ 23.18万
  • 项目类别:
Improving Neuronal Plasticity in a Mouse Model of FASD
改善 FASD 小鼠模型的神经元可塑性
  • 批准号:
    8798554
  • 财政年份:
    2014
  • 资助金额:
    $ 23.18万
  • 项目类别:
Alcohol in Neocortex Development and Plasticity
酒精在新皮质发育和可塑性中的作用
  • 批准号:
    9926203
  • 财政年份:
    2001
  • 资助金额:
    $ 23.18万
  • 项目类别:
Alcohol in Neocortex Development and Plasticity
酒精在新皮质发育和可塑性中的作用
  • 批准号:
    8583074
  • 财政年份:
    2001
  • 资助金额:
    $ 23.18万
  • 项目类别:
Alcohol in Neocortex Development and Plasticity
酒精在新皮质发育和可塑性中的作用
  • 批准号:
    8461671
  • 财政年份:
    2001
  • 资助金额:
    $ 23.18万
  • 项目类别:
Alcohol in Neocortex Development and Plasticity
酒精在新皮质发育和可塑性中的作用
  • 批准号:
    7887815
  • 财政年份:
    2001
  • 资助金额:
    $ 23.18万
  • 项目类别:
Alcohol in Neocortex Development and Plasticity
酒精在新皮质发育和可塑性中的作用
  • 批准号:
    7036983
  • 财政年份:
    2001
  • 资助金额:
    $ 23.18万
  • 项目类别:
Alcohol in Neocortex Development and Plasticity
酒精在新皮质发育和可塑性中的作用
  • 批准号:
    8660249
  • 财政年份:
    2001
  • 资助金额:
    $ 23.18万
  • 项目类别:

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