Short Course on the Genetics of Addiction

摘要 在本申请中提出的关于成瘾遗传学的年度短期课程建立在 本课程的上一次迭代，将为学生提供了解基因的机会 药物成瘾研究在人体和模型生物体中的应用和方法。方法论 说明包括从与成瘾相关的表型研究中获得的例子、文献和数据集， 关于成瘾遗传学主要进展的全体会议，以及讨论会议，在讨论中，每个学生 介绍他们在基因方法应用方面的工作，并讨论讲座引发的一般问题。 学生将能够设计和解释成瘾的基因和基因组研究，因为他们 与他们的具体研究问题有关，以定位机会和资源之间的推断 他们还将利用现有的在线数据资源来支持他们的研究。 这些目标将在未来五年内每年通过为期五天的强化课程实现 于夏末在缅因州巴尔港的杰克逊实验室(JAX)提供。2020年，该课程将举办 9月20日至26日，9月20日抵达并举行招待会，9月26日出发。 参赛者将因其在与课程相关的领域中的杰出研究潜力而被选中，并将拥有 有机会与一群著名的计算生物学家、生物信息学家、生物学家和 来自日本宇宙航空研究开发机构和其他机构的遗传学家。授课课程和实践培训的结合将是 白天提供，晚上进行非正式讨论。学生入学是故意的 保持较小(35个)，以实现理想的师生互动水平。食宿将在以下地点提供 日本宇宙航空研究开发机构拥有的公海会议中心，它创造了一个非常有利于互动的氛围 在学生和教职员工之间。主要的重点将放在吸引有前途的年轻调查人员 参加这一课程，并积极促进将妇女和任职人数不足的少数群体纳入 培养教授多样性的努力。

ABSTRACT The annual Short Course on the Genetics of Addiction proposed in this application builds on the successes of the previous iteration of this Course and will provide students with an opportunity to learn about genetic applications and approaches to drug addiction research in humans and model organisms. The methodological instruction includes examples, literature and data sets drawn from studies of addiction-related phenotypes, plenary sessions on major progress in addiction genetics, and discussion sessions in which students each present their work on applications of genetic methods, and discuss general questions provoked by the lectures. Students will leave the course able to design and interpret genetic and genomic studies of addiction as they relate to their specific research question, to locate the opportunities and resources for extrapolation between human genetics and model organisms, and to utilize current online data resources to support their research. These aims will be accomplished annually over the next five years through an intensive five-day course to be offered in late summer at the Jackson Laboratory (JAX) in Bar Harbor, Maine. In 2020, the course will be held September 20-26, with arrivals and a reception on September 20 and departures on September 26. Participants will be chosen for their outstanding research potential in fields relevant to the course and will have the opportunity to interact with a group of prominent computational biologists, bioinformaticists, biologists, and geneticists from JAX and other institutions. A combination of didactic sessions and hands-on training will be offered during the day and informal discussions will be held in the evening. Student enrollment is deliberately kept small (35) to achieve a desirable level of student-faculty interaction. Food and lodging will be provided at the JAX-owned Highseas Conference Center, which creates an atmosphere highly conducive to interactions between students and faculty. A major emphasis will be placed on attracting promising young investigators to participate in this course and to actively promote the inclusion of women and under-represented minorities in an effort to cultivate diversity in the professoriate.