Molecular mechanisms of alveolar development and regeneration
Molecular mechanisms of alveolar development and regeneration
批准号:
10201731
负责人:
PAO-TIEN CHUANG
金额:
$51.68万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2022-06-30
关键词:
AblationActomyosinAdoptedAdultAffectAlveolarAlveolar CellAlveolar Cell Type IBiological AssayBleomycinBronchopulmonary DysplasiaCandidate Disease GeneCell CommunicationCell ShapeCell physiologyCellsChronic Obstructive Airway DiseaseCytoskeletonDefectDevelopmentDiagnosisDistalElectron MicroscopyEpithelialEpithelial CellsFailureFoundationsFutureGeneticGoalsHumanKnowledgeLigandsLungLung diseasesMediatingMembraneMesenchymalMesenchymeModelingMolecularMolecular AnalysisMusMyofibroblastNatural regenerationNatureNeonatalOrganoidsPathogenesisPathway interactionsPlatelet-Derived Growth FactorPlatelet-Derived Growth Factor alpha ReceptorProcessResolutionRoleSignal PathwaySignal TransductionStromal CellsSystemTechniquesTechnologyTestingType I Epithelial Receptor Cellalveolar type II cellcell typedesigngenetic analysishuman diseaseinsightlight microscopylung developmentlung imaginglung injuryplanar cell polarityreceptorreconstitutionregenerativeresponsetranscriptome sequencing
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
This application aims to elucidate the molecular mechanisms of alveolar formation during development and in
response to lung injury. We anticipate that our study will provide new insight into the pathogenesis of human
lung diseases caused by the failure of alveolar development or regeneration, notably bronchopulmonary
dysplasia (BPD) and chronic obstructive lung disease (COPD), respectively. In preliminary studies, we have
discovered a critical role of planar cell polarity (PCP) in controlling alveolar formation. In this proposal, we aim
to test how PCP signaling mediates cell-cell interactions between alveolar cells and mesenchymal
myofibroblasts, leading to PDGF signaling, cell shape changes and alveolar formation. Our specific aims are:
(1) To test the hypothesis that Vangl2-mediated planar cell polarity is required for PDGF signaling and cell
shape changes during alveolar formation in development; (2) To test the hypothesis that a Wnt5a-Vangl2 axis
controls alveolar formation; and (3) To molecularly characterize realveolarization following lung injury in adults.
Taken together, these studies will increase our mechanistic understanding of alveolar formation during
development and following lung injury and facilitate future diagnosis and treatment of lung diseases caused
by loss of alveoli.
期刊论文(5)
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科研奖励(0)
会议论文
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DOI:
10.1016/j.devcel.2022.05.021
发表时间:
2022-07-11
期刊:
DEVELOPMENTAL CELL
影响因子:
11.8
作者:
[Zhang, Kuan, Yao, Erica, Wang, Shao-An, Chuang, Ethan, Wong, Julia, Minichiello, Liliana, Schroeder, Andrew, Eckalbar, Walter, Wolters, Paul J., Chuang, Pao-Tien]
通讯作者:
Chuang, Pao-Tien
DOI:
10.7554/elife.68598
发表时间:
2022-04-06
期刊:
ELIFE
影响因子:
7.7
作者:
[Zhang, Kuan, Yao, Erica, Chen, Biao, Chuang, Ethan, Wong, Julia, Seed, Robert, I, Nishimura, Stephen L., Wolters, Paul J., Chuang, Pao-Tien, Koenigshoff, Melanie]
通讯作者:
Koenigshoff, Melanie
DOI:
10.1038/s41467-022-34763-y
发表时间:
2022-11-25
期刊:
NATURE COMMUNICATIONS
影响因子:
16.6
作者:
[Zhang, Kuan, Yao, Erica, Chuang, Ethan, Chen, Biao, Chuang, Evelyn Y., Chuang, Pao-Tien]
通讯作者:
Chuang, Pao-Tien
DOI:
10.1371/journal.pbio.3001759
发表时间:
2022-08
期刊:
PLOS BIOLOGY
影响因子:
9.8
作者:
[Zhang, Kuan, Yao, Erica, Chuang, Ethan, Chen, Biao, Chuang, Evelyn Y., Volk, Regan F., Hofmann, Katherine L., Zaro, Balyn, Chuang, Pao-Tien]
通讯作者:
Chuang, Pao-Tien
Autonomic innervation regulates alveolar formation in development
-
批准号:10366808
-
项目类别:
-
资助金额:$57.85万
-
财政年份:2022
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Autonomic innervation regulates alveolar formation in development
-
批准号:10592271
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项目类别:
-
资助金额:$57.85万
-
财政年份:2022
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Sufu-interacting proteins provide novel insight into mammalian Hedgehog signaling
-
批准号:8888411
-
项目类别:
-
资助金额:$30.5万
-
财政年份:2015
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Sufu-interacting proteins provide novel insight into mammalian Hedgehog signaling
-
批准号:9056592
-
项目类别:
-
资助金额:$30.51万
-
财政年份:2015
-
负责人:PAO-TIEN CHUANG
-
依托单位:
The lineage and function of neuroendocrine cells in lung homeostasis and injury
-
批准号:8506375
-
项目类别:
-
资助金额:$37.37万
-
财政年份:2013
-
负责人:PAO-TIEN CHUANG
-
依托单位:
The lineage and function of neuroendocrine cells in lung homeostasis and injury
-
批准号:8881297
-
项目类别:
-
资助金额:$39.03万
-
财政年份:2013
-
负责人:PAO-TIEN CHUANG
-
依托单位:
The lineage and function of neuroendocrine cells in lung homeostasis and injury
-
批准号:9102214
-
项目类别:
-
资助金额:$39.63万
-
财政年份:2013
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Epithelial Progenitor Cells in Lung Repair and Regeneration
-
批准号:8403692
-
项目类别:
-
资助金额:$62.97万
-
财政年份:2012
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Epithelial Progenitor Cells in Lung Repair and Regeneration
-
批准号:8598931
-
项目类别:
-
资助金额:$63.36万
-
财政年份:2012
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Epithelial Progenitor Cells in Lung Repair and Regeneration
-
批准号:8786594
-
项目类别:
-
资助金额:$62.23万
-
财政年份:2012
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Epithelial Progenitor Cells in Lung Repair and Regeneration
-
批准号:8224313
-
项目类别:
-
资助金额:$69.53万
-
财政年份:2012
-
负责人:PAO-TIEN CHUANG
-
依托单位:
The molecular mechanisms by which mammalian Fused regulates motile cilia function
-
批准号:7997215
-
项目类别:
-
资助金额:$38.63万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
The molecular mechanisms by which mammalian Fused regulates motile cilia function
-
批准号:7581534
-
项目类别:
-
资助金额:$38.63万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
The molecular mechanisms by which mammalian Fused regulates motile cilia function
-
批准号:7749572
-
项目类别:
-
资助金额:$38.63万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Molecular Mechanisms of Mammalian Hedgehog Signal Transduction
-
批准号:7506250
-
项目类别:
-
资助金额:$30.9万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Molecular Mechanisms of Mammalian Hedgehog Signal Transduction
-
批准号:7658940
-
项目类别:
-
资助金额:$30.9万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Molecular Mechanisms of Mammalian Hedgehog Signal Transduction
-
批准号:7893050
-
项目类别:
-
资助金额:$30.59万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
Molecular Mechanisms of Mammalian Hedgehog Signal Transduction
-
批准号:8101173
-
项目类别:
-
资助金额:$30.29万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
The molecular mechanisms by which mammalian Fused regulates motile cilia function
-
批准号:8197207
-
项目类别:
-
资助金额:$38.24万
-
财政年份:2008
-
负责人:PAO-TIEN CHUANG
-
依托单位:
CORE--MOUSE
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批准号:6930110
-
项目类别:
-
资助金额:$23.56万
-
财政年份:2004
-
负责人:PAO-TIEN CHUANG
-
依托单位:
国内基金
海外基金
由actomyosin介导的集体性细胞迁移对唇腭裂发生的影响的研究
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批准号:82360313
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项目类别:地区科学基金项目
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资助金额:32万元
-
批准年份:2023
-
负责人:滕藤
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依托单位: