Rapid‐Response Macromolecular Crystallography

快速响应高分子晶体学

• 批准号: 10201648
• 负责人: CORIE Y RALSTON
• 金额: $ 35.74万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-09-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201648
• 关键词: Address; Automation; Biological; Biomedical Research; Collaborations; Collection; Communities; Country; Crystallization; Crystallography; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Funding; Goals; Home; Individual; Link; Methods; Notification; Positioning Attribute; Process; Research Personnel; Resources; Robotics; Running; Sampling; Scientist; Services; Ships; Structure; Synchrotrons; System; Techniques; Technology; Time; Training; United States National Institutes of Health; Vision; automated analysis; base; beamline; computerized data processing; experience; experimental study; high throughput screening; instrumentation; operation; programs; response; service programs; skills; staff intervention; structural biology; success; synergism; tool

Project Summary/Abstract – Technology Operations Core 1 (TOC1) The goal of the proposed ALS-ENABLE resource is to provide an integrated and state-of-the-art structural biology resource for NIH investigators across the country. TOC1 in particular brings together the eight ALS macromolecular crystallography (MX) synchrotron beamlines into one national resource, creating a unified program which extends the individual beamline strengths to the entire resource, while providing a single interface to meet the user community needs for beamtime, data collection and data processing. The ALS structural biology beamlines are state-of-the-art "mature" resources, collectively serving hundreds of users annually, with dedicated beamline scientists with strong long-term collaborations with NIH-funded PIs across the country. The three aims in TOC1 link the current automation technologies developed at the eight resource beamlines into one complete automation pipeline, extend remote access crystallography to all the resource beamlines, and formalize and unify the current collaborative crystallography efforts into one program. The ALS- ENABLE resource brings together for the first time the four independent MX groups at the ALS, their eight endstations, and the Collaborative Crystallography program into one national resource. This integration of structural biology synchrotron beamlines at the ALS allows significant synergies and efficiencies. It builds on the current success of the structural biology beamlines, enabling structural biology solutions on the most challenging and relevant biological problems, thus serving the needs of the national biomedical research community.

项目摘要/摘要-技术运作核心1 （TOC1）