Training Program in Free Radical and Radiation Biology

项目概要/摘要： 放射肿瘤学系自由基与放射生物学培训计划 霍尔顿综合癌症中心成立于1998年，提供跨学科的研究生和博士后， 研究生培训的重点是六个目标，包括：1）传授辐射的基本认识 生物学，自由基生物学和癌症生物学; 2）提供机会，以实现卓越的实验 放射生物学、自由基生物学和分子肿瘤学; 3）为学员提供假设技能 驱动的研究，执行严格的实验设计，并严格评估科学结果， 同行评审的出版物; 4）提供合作基础和转化研究的真实经验 涉及临床和基础科学教师，以促进自由基和 从工作台到床边的辐射生物学; 5）为学员提供必要的批判性思维技能， 在口头和书面报告中有效地传达科学知识; 6）鼓励学员 追求创新的方法来测试放射生物学和氧化还原癌症生物学的基本机制 强调开发新的干预措施，以限制癌症对健康的影响。 我们建议每年资助三名博士前和三名博士后学员。我们有一个 国际公认的教师与同行评审资助的成功的一贯记录 放射生物学、氧化还原生物学和癌症生物学方面的研究/出版物。我们建议26个资金充足的 和专门的计划教师（包括初级和高级教师）拥抱多元化的知识基础 协同整合了自由基和辐射的跨学科研究生课程 爱荷华州大学生物医学科学伞计划中的生物学和癌症生物学。的 26个项目的教职员工包括15名教授，8名副教授和3名助理教授。 其中5名来自放射肿瘤科，3名来自外科，5名来自内科，3名来自生化，2名来自 药理学，2名来自解剖学和细胞生物学，3名来自儿科，1名来自微生物学/免疫学， 放射学、分子生理学和生物物理学。教育活动包括一对一的指导， 教师，癌症相关的国家认可的研究项目，提出工作和接受反馈，在 国家会议，2个项目特定的期刊俱乐部/周，1个研讨会/周，1个翻译研究 会议/周，并在最先进的辐射和自由基研究核心实验室进行技术培训 基于该计划。正式的研究生课程包括辐射、氧化还原和癌症 生物学以及医学物理学课程，重点是图像引导的癌症治疗。的 教师们正在进行的跨学科癌症相关研究涵盖了从基础到广泛的范围 从机制研究到转化临床前研究以及临床研究。该计划成立于1961年 并培养了150多名从事癌症研究、氧化还原生物学和生物医学科学的科学家。

Project Summary/Abstract: The Free Radical and Radiation Biology Training Program in the Department of Radiation Oncology and the Holden Comprehensive Cancer Center was established in 1998 to provide interdisciplinary graduate and post- graduate training with a focus on six goals including: 1) Impart a fundamental understanding of radiation biology, free radical biology, and cancer biology; 2) Provide opportunities to achieve excellence in experimental radiation biology, free radical biology, and molecular oncology; 3) Provide trainees with skills in hypothesis driven research, execution of rigorous experimental designs, and rigorous evaluation of scientific results for peer-reviewed publication; 4) Offer real-world experiences in collaborative basic and translational research involving both clinical and basic science faculty to facilitate the movement of knowledge in free radical and radiation biology from the bench-to-bedside; 5) Provide trainees with the critical thinking skills necessary to effectively communicate scientific knowledge in both oral and written presentations; and 6) Encourage trainees to pursue innovative approaches to test basic mechanisms underlying radiobiology and redox cancer biology emphasizing the development of novel interventions to limit the health impact of cancer. We are proposing to support three predoctoral and three postdoctoral trainees per year. We have an internationally recognized faculty with a consistent track record of success in peer reviewed funded research/publications in radiobiology, redox biology, and cancer biology. We propose to have 26 well-funded and dedicated program faculty members (both junior and senior faculty) embracing a diverse knowledge base that synergistically integrates both the interdisciplinary graduate programs in Free Radical and Radiation Biology as well as Cancer Biology in the Biomedical Sciences Umbrella program at the University of Iowa. The 26 program faculty members consist of 15 Professors, 8 Associate Professors, and 3 Assistant Professors of which 5 are from Radiation Oncology, 3 from Surgery, 5 from Internal Medicine, 3 from Biochemistry, 2 from Pharmacology, 2 from Anatomy and Cell Biology, 3 from Pediatrics and 1 each from Microbiology/Immunology, Radiology, and Molecular Physiology and Biophysics. Educational activities include one-on-one mentoring by faculty, cancer-related nationally recognized research projects, presenting work and receiving feedback at national meetings, 2 program specific journal clubs/week, 1 seminar/week, 1 translational research meeting/week, and technical training in the state of-the-art Radiation and Free Radical Research core lab based in the program. Formal graduate level coursework includes classes in radiation, redox, and cancer biology as well as a course in medical physics with an emphasis on image guided cancer therapy. The interdisciplinary cancer related research being pursued by the faculty spans a wide spectrum from basic mechanistic studies to translational preclinical as well as clinical studies. The program was established in 1961 and has trained more that 150 scientists working in cancer research, redox biology, and biomedical sciences.