Training Program in Free Radical and Radiation Biology

项目摘要/摘要： 放射肿瘤科的自由基和放射生物学培训计划 霍尔登综合癌症中心成立于1998年，旨在提供跨学科的毕业生和博士后 研究生培训，重点是六个目标，包括：1)传授对辐射的基本了解 生物学、自由基生物学和癌症生物学；2)提供在实验方面取得卓越成绩的机会 辐射生物学、自由基生物学和分子肿瘤学；3)为学员提供假设技能 推动研究，执行严格的实验设计，并严格评估科学结果 同行评议的出版物；4)提供合作基础研究和翻译研究的真实体验 让临床和基础科学学院参与，以促进自由基和 从工作台到床边的放射生物学；5)为学员提供必要的批判性思维技能 在口头和书面陈述中有效地传播科学知识；以及6)鼓励学员 寻求创新的方法来测试放射生物学和氧化还原癌症生物学的基本机制 强调开发新的干预措施，以限制癌症对健康的影响。 我们建议每年支持三名博士后和三名博士后实习生。我们有一个 国际公认的教职员工，在同行评议资助方面取得了一致的成功记录 放射生物学、氧化还原生物学和癌症生物学的研究/出版。我们建议有26个资金充足的 和敬业的项目教员(初级和高级教员)，接受多样化的知识基础 它协同地整合了自由基和辐射方面的跨学科研究生课程 爱荷华大学生物医学科学伞项目中的生物学和癌症生物学。这个 26名教职员工包括15名教授、8名副教授和3名助理教授 其中5人来自放射肿瘤学，3人来自外科，5人来自内科，3人来自生物化学，2人来自 药理学，解剖学和细胞生物学2人，儿科3人，微生物学/免疫学各1人， 放射学、分子生理学和生物物理学。教育活动包括一对一辅导，由 教授，与癌症相关的国家认可的研究项目，介绍工作并在 全国性会议、2个项目特定期刊俱乐部/周、1个研讨会/周、1个翻译研究 会议/周，在最先进的辐射和自由基研究核心实验室进行技术培训 以程序为基础。正规的研究生课程包括辐射、氧化还原和癌症课程。 生物学以及医学物理学课程，重点是图像引导的癌症治疗。这个 教师正在进行的与癌症相关的跨学科研究涵盖了从基础到基础的广泛领域 从机械学研究到翻译性临床前研究以及临床研究。该项目成立于1961年。 并培训了150多名从事癌症研究、氧化还原生物学和生物医学科学工作的科学家。

Project Summary/Abstract: The Free Radical and Radiation Biology Training Program in the Department of Radiation Oncology and the Holden Comprehensive Cancer Center was established in 1998 to provide interdisciplinary graduate and post- graduate training with a focus on six goals including: 1) Impart a fundamental understanding of radiation biology, free radical biology, and cancer biology; 2) Provide opportunities to achieve excellence in experimental radiation biology, free radical biology, and molecular oncology; 3) Provide trainees with skills in hypothesis driven research, execution of rigorous experimental designs, and rigorous evaluation of scientific results for peer-reviewed publication; 4) Offer real-world experiences in collaborative basic and translational research involving both clinical and basic science faculty to facilitate the movement of knowledge in free radical and radiation biology from the bench-to-bedside; 5) Provide trainees with the critical thinking skills necessary to effectively communicate scientific knowledge in both oral and written presentations; and 6) Encourage trainees to pursue innovative approaches to test basic mechanisms underlying radiobiology and redox cancer biology emphasizing the development of novel interventions to limit the health impact of cancer. We are proposing to support three predoctoral and three postdoctoral trainees per year. We have an internationally recognized faculty with a consistent track record of success in peer reviewed funded research/publications in radiobiology, redox biology, and cancer biology. We propose to have 26 well-funded and dedicated program faculty members (both junior and senior faculty) embracing a diverse knowledge base that synergistically integrates both the interdisciplinary graduate programs in Free Radical and Radiation Biology as well as Cancer Biology in the Biomedical Sciences Umbrella program at the University of Iowa. The 26 program faculty members consist of 15 Professors, 8 Associate Professors, and 3 Assistant Professors of which 5 are from Radiation Oncology, 3 from Surgery, 5 from Internal Medicine, 3 from Biochemistry, 2 from Pharmacology, 2 from Anatomy and Cell Biology, 3 from Pediatrics and 1 each from Microbiology/Immunology, Radiology, and Molecular Physiology and Biophysics. Educational activities include one-on-one mentoring by faculty, cancer-related nationally recognized research projects, presenting work and receiving feedback at national meetings, 2 program specific journal clubs/week, 1 seminar/week, 1 translational research meeting/week, and technical training in the state of-the-art Radiation and Free Radical Research core lab based in the program. Formal graduate level coursework includes classes in radiation, redox, and cancer biology as well as a course in medical physics with an emphasis on image guided cancer therapy. The interdisciplinary cancer related research being pursued by the faculty spans a wide spectrum from basic mechanistic studies to translational preclinical as well as clinical studies. The program was established in 1961 and has trained more that 150 scientists working in cancer research, redox biology, and biomedical sciences.