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中文摘要
翻译
爱荷华州神经内分泌肿瘤孢子开发研究计划的目标是带来新的 思想和创新技术,用于诊断、治疗,并最终预防 神经内分泌肿瘤。发展研究计划将提供高达50,000美元的一年 (孢子基金25,000美元和机构资源25,000美元)分别用于两个项目 根据进展情况,有可能再提供第二年的支助。预计将支持 发展研究项目将继续产生新的假说,并对其进行检验 在完全由孢子赞助的项目中或通过同行审查的外部赠款支助。中国的长期目标是 爱荷华州神经内分泌肿瘤孢子项目是将开发项目产生的发现转化为 改善神经内分泌肿瘤患者的生活时间和质量。更具体地说, 发展研究计划的目标是:(1)鼓励创新的翻译人口, 神经内分泌肿瘤的实验室和临床研究;(2)促进基础设施之间的广泛合作 神经内分泌肿瘤的转化研究中的科学、人口科学和临床学科;以及,(3) 生成新的假设,以在大规模研究项目或临床试验中进行测试,这可能会导致 神经内分泌肿瘤的发病率和死亡率显著降低。三大潜力的简要概述 包括发展研究项目,以展示正在进行的研究的深度和广度 可以应用于神经内分泌肿瘤的翻译研究,并将有资格进入爱荷华州 神经内分泌肿瘤孢子发育计划支持。 �
英文摘要
The goal of the Developmental Research Program in the Iowa Neuroendocrine Tumor SPORE is to bring new ideas and innovative techniques to bear on the diagnosis, curative therapy, and ultimately, the prevention of neuroendocrine tumors. The Developmental Research Program will provide up to $50,000 for one year ($25,000 from SPORE funds and a matching $25,000 from institutional resources) to each of two projects each year with the possibility of a second year of support based on progress. It is anticipated that support of developmental research projects will continue to result in the generation of new hypotheses that will be tested in full SPORE-sponsored projects or through peer reviewed external grant support. The long-term goal of the Iowa Neuroendocrine Tumor SPORE program is to translate the findings generated by developmental projects into an improved length and quality of life for patients with neuroendocrine tumors. More specifically, the objectives of the Developmental Research Program are to: (1) encourage innovative translational population, laboratory, and clinical studies in neuroendocrine tumors; (2) foster extensive collaboration between basic science, population science and clinical disciplines in translational research in neuroendocrine tumors; and, (3) generate new hypotheses to be tested in large-scale research projects or clinical trials that may lead to significant reduction in incidence and mortality of neuroendocrine tumors. Brief outlines of three potential developmental research projects are included to demonstrate the depth and breadth of ongoing research that can be applied to the translational research in neuroendocrine tumors and would be eligible for Iowa Neuroendocrine Tumor SPORE Developmental Program support. �
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Project 2: Exploiting Labile Iron Pools for Improving NSCLC Therapy Using Pharmacological Ascorbate
  • 批准号:
    10240531
  • 项目类别:
  • 资助金额:
    $47.73万
  • 财政年份:
    2018
  • 负责人:
    Douglas Robert Spitz
  • 依托单位:
Project 2: Exploiting Labile Iron Pools for Improving NSCLC Therapy Using Pharmacological Ascorbate
  • 批准号:
    10005908
  • 项目类别:
  • 资助金额:
    $47.73万
  • 财政年份:
    2018
  • 负责人:
    Douglas Robert Spitz
  • 依托单位:
Enhancing Metabolic Oxidative Stress and Therapy Responses in Cancer Stem Cells
  • 批准号:
    8623548
  • 项目类别:
  • 资助金额:
    $33.84万
  • 财政年份:
    2013
  • 负责人:
    Douglas Robert Spitz
  • 依托单位:
Enhancing Metabolic Oxidative Stress and Therapy Responses in Cancer Stem Cells
  • 批准号:
    8776281
  • 项目类别:
  • 资助金额:
    $33.84万
  • 财政年份:
    2013
  • 负责人:
    Douglas Robert Spitz
  • 依托单位:
海外基金