Free Radical Cancer Biology Program

自由基癌症生物学计划

基本信息

  • 批准号:
    7900743
  • 负责人:
  • 金额:
    $ 1.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-07-01 至 2010-06-30
  • 项目状态:
    已结题

项目摘要

Research in the Free Radical Cancer Biology Program focuses on oxidative events in cancer, including free radicals, cell redox state and effects of anticancer drugs, radiation and other types of anticancer therapy. The overall goals of the members of this program are to identify ways of manipulating cellular redox state to improve cancer therapy and to understand the changes in oxidation associated with neoplastic disease. There are four major overlapping themes within the Program's research. Theme 1 - Understanding the role of oxidative and nitrosative events and signaling in cancer biology. Theme 2 - Augmenting cancer therapy using modulation of antioxidant enzymes, free radicals or oxidative strategies Theme 3 - The role of nitric oxide in cancer biology and cancer treatment Theme 4 - Understanding why neoplasia is more frequent and sometimes has a different biology as we age. The major accomplishments of the Free Radical Cancer Biology Program over the past funding period include the findings that (a) AdMnSOD transduction is an effective treatment for animal models of human oral cancer, (b) nitric oxide augments cell cytotoxicity of doxorubicin for a malignant breast cancer cell, but not for a cardiac cells, (c) there is a role for DNA methylation in the establishment and/or maintenance of cell-type specific gene expression, (d) there is a blunted ability in old animals to buffer potentially harmful oxidants being produced within a cell following an acute stress, and (e) that the antioxidant enzyme phospholipid glutathione peroxidase influences the growth rate of cells by altering the peroxide tone. There are numerous past and present productive collaborations both between members of the Program, and with members of other Cancer Center programs. For example, the Program Project Grant in Oxidative Events in Cancer Therapy and our participation in the Aging and Cancer P20 involve many members and are highly interactive and programmatic. The Free Radical Cancer Biology Program consists of 17 members from 9 departments and 2 colleges. Peer-reviewed, research funding for this program totals $2,230,523 with $1,624,781 coming from the NCI.
自由基癌症生物学项目的研究重点是癌症中的氧化事件,包括自由基、细胞氧化还原状态和抗癌药物、辐射和其他类型的抗癌治疗的作用。该计划成员的总体目标是确定操纵细胞氧化还原状态的方法,以改善癌症治疗,并了解与肿瘤疾病相关的氧化变化。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Douglas Robert Spitz其他文献

Douglas Robert Spitz的其他文献

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{{ truncateString('Douglas Robert Spitz', 18)}}的其他基金

Project 2: Exploiting Labile Iron Pools for Improving NSCLC Therapy Using Pharmacological Ascorbate
项目 2:利用药理学抗坏血酸利用不稳定铁池改善 NSCLC 治疗
  • 批准号:
    10240531
  • 财政年份:
    2018
  • 资助金额:
    $ 1.96万
  • 项目类别:
Project 2: Exploiting Labile Iron Pools for Improving NSCLC Therapy Using Pharmacological Ascorbate
项目 2:利用药理学抗坏血酸利用不稳定铁池改善 NSCLC 治疗
  • 批准号:
    10005908
  • 财政年份:
    2018
  • 资助金额:
    $ 1.96万
  • 项目类别:
Developmental Research Program
发展研究计划
  • 批准号:
    8850629
  • 财政年份:
    2015
  • 资助金额:
    $ 1.96万
  • 项目类别:
Enhancing Metabolic Oxidative Stress and Therapy Responses in Cancer Stem Cells
增强癌症干细胞的代谢氧化应激和治疗反应
  • 批准号:
    8623548
  • 财政年份:
    2013
  • 资助金额:
    $ 1.96万
  • 项目类别:
Enhancing Metabolic Oxidative Stress and Therapy Responses in Cancer Stem Cells
增强癌症干细胞的代谢氧化应激和治疗反应
  • 批准号:
    8776281
  • 财政年份:
    2013
  • 资助金额:
    $ 1.96万
  • 项目类别:
Radiation and Free Radical Research Core
辐射和自由基研究核心
  • 批准号:
    7900763
  • 财政年份:
    2009
  • 资助金额:
    $ 1.96万
  • 项目类别:
Enhancement of Cancer Therapy Using Ketogenic Diets
使用生酮饮食增强癌症治疗
  • 批准号:
    7639109
  • 财政年份:
    2009
  • 资助金额:
    $ 1.96万
  • 项目类别:
The Use of 2-Deoxyglucose in Head and Neck Cancer Therapy
2-脱氧葡萄糖在头颈癌治疗中的应用
  • 批准号:
    8197317
  • 财政年份:
    2008
  • 资助金额:
    $ 1.96万
  • 项目类别:
The Use of 2-Deoxyglucose in Head and Neck Cancer Therapy
2-脱氧葡萄糖在头颈癌治疗中的应用
  • 批准号:
    7613858
  • 财政年份:
    2008
  • 资助金额:
    $ 1.96万
  • 项目类别:
The Use of 2-Deoxyglucose in Head and Neck Cancer Therapy
2-脱氧葡萄糖在头颈癌治疗中的应用
  • 批准号:
    7741711
  • 财政年份:
    2008
  • 资助金额:
    $ 1.96万
  • 项目类别:

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飓风和社会缓冲对自由放养动物模型生物衰老的影响
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