Research and Mentoring in Innovative Patient Oriented Pain and Opioid Science

项目摘要：此K24应用程序的主要目标是允许Beth Darnall博士(1)提供高- 在以患者为中心的研究(POR)中对职业生涯早期研究人员的质量和密集指导；以及(2) 获得新的研究方法培训，以支持数字健康研究在人群中的扩展 阿片类药物使用障碍的连续体。K24奖将为Darnall博士提供关键的保护时间 POR和指导，否则将花费在行政和临床责任上。达纳尔博士是 斯坦福大学学院斯坦福止痛创新实验室副教授兼主任 医学部。Darnall博士计划将她对可扩展数字行为医学的研究范围扩展到 患有慢性疼痛和处方阿片类药物滥用的人，然后进行全国虚拟 随机对照试验，以调查对疼痛和阿片类药物结局的影响。她的指导计划包括 组织指导：(1)设计和实施POR研究；(2)准备科学论文和 演讲；(3)撰写和提交成功的研究资助申请；(4)道德和负责任的 进行研究；以及(5)专业精神和学术进程的成功导航，以实现 科学上的独立。受训人员将来自多种现有来源，包括斯坦福临床 和翻译科学奖(CTSA)，疼痛部门关于疼痛和物质使用的NIDA T32计划 精神障碍，疼痛部门的疼痛心理学和董事会认证的疼痛医生奖学金计划， 斯坦福大学本科教育副教务长奖学金(VPUE)，以及她的多个活跃的国家 和国际研究合作。Darnall博士将通过组合来完成她的指导计划 个人和小组会议、协作指导、角色建模和参与跨部门 在讲座和国家会议上。此外，她将把她的学员紧密地融入斯坦福CTSA 导师计划和斯坦福大学教师多样性和发展办公室提供的广泛服务， 包括NIH K系列和R系列拨款密集型写作计划。她的职业发展计划 包括数字健康设计方面的培训，以优化增强用户的数字行为治疗 参与和应对，以及关于执行科学、阿片类药物政策和高级 来自斯坦福大学教师领导力项目的指导。达纳尔博士有出色的资源，长期- 长期成功的研究合作，以及大量活跃的资金组合。拟议的K24 研究和其他计划中的项目有望在研究方面带来新的方向和创新 疼痛和阿片类药物使用障碍的连续体，并显著有助于我们对 这些禁用条件。Darnall博士将利用K24和她现有的资源提供关键的 培训致力于开展有影响力的、以患者为中心的研究的下一代科学家。

Project Summary: The primary goals of this K24 application are to allow Beth Darnall, PhD to (1) provide high- quality and intensive mentorship of early-career investigators in patient-oriented research (POR); and (2) acquire new training in research methodologies to support expansion of digital health research in populations on the continuum of opioid use disorder. A K24 award will provide Dr. Darnall with the critical protected time for POR and mentoring that would otherwise be spent on administrative and clinical responsibilities. Dr. Darnall is Associate Professor and Director of the Stanford Pain Relief Innovations Lab at the Stanford University School of Medicine. Dr. Darnall proposes to extend her line of research on scalable digital behavioral medicine to people with comorbid chronic pain and prescription opioid misuse, and then conduct a national virtual randomized controlled trail to investigate impacts on pain and opioid outcomes. Her mentoring plan includes structured mentoring in: (1) designing and implementing POR studies; (2) preparing scientific papers and presentations; (3) writing and submitting successful research grant applications; (4) ethical and responsible conduct of research; and (5) professionalism and successful navigation of the academic process to achieve scientific independence. Trainees will be derived from multiple current sources including the Stanford Clinical and Translational Science Award (CTSA), the Pain Division's NIDA T32 program on pain and substance use disorder, the Pain Division's pain psychology and board certified pain physician fellowship programs, the Stanford fellowship for the Vice Provost for Undergraduate Education (VPUE), and her multiple active national and international research collaborations. Dr. Darnall will accomplish her mentoring plan through a combination of individual and group meetings, collaborative mentoring, role modeling, and participation in interdepartmental lectures and at national meetings. Additionally, she will closely integrate her mentees into the Stanford CTSA mentoring program and the extensive offerings of the Stanford Office for Faculty Diversity and Development, including the NIH K-series and R-series grant intensive writing programs. Her career development plan includes training in digital health design to optimize digital behavioral treatments for enhanced user engagement and response, as well as trainings in implementation science, opioid policy, and advanced mentoring from the Stanford Faculty Leadership Program. Dr. Darnall has outstanding resources, long- standing successful research collaborations, and a substantial active funding portfolio. The proposed K24 research and other planned projects are expected to lead to new directions and innovations in research on pain and the continuum of opioid use disorder, and significantly contribute to our scientific understanding of these disabling conditions. Dr. Darnall will leverage the K24 and her existing resources to provide crucial training to the next generation of scientists dedicated to conducting impactful patient-oriented research.