Research and Mentoring in Innovative Patient Oriented Pain and Opioid Science

项目摘要：这个K24应用程序的主要目标是让Beth Darnall博士（1）提供高- 在面向患者的研究（POR）中对早期职业研究者的质量和强化指导;以及（2） 获得研究方法方面的新培训，以支持在人群中扩展数字健康研究 阿片类药物使用障碍的连续性。K24奖将为Darnall博士提供关键的保护时间， POR和指导，否则将花费在行政和临床责任。达纳尔博士是 斯坦福大学学院副教授兼斯坦福大学疼痛缓解创新实验室主任 医学。Darnall博士建议将她在可扩展的数字行为医学方面的研究扩展到 患有慢性疼痛和处方阿片类药物滥用共病的人，然后进行全国虚拟 随机对照试验，研究对疼痛和阿片类药物结局的影响。她的指导计划包括 结构化指导：（1）设计和实施POR研究;（2）编写科学论文， 演讲;（3）撰写并提交成功的研究资助申请;（4）道德和负责任 研究的进行;和（5）专业和学术过程的成功导航，以实现 科学独立。学员将来自多个现有来源，包括斯坦福大学临床 和转化科学奖（CTSA），疼痛司的NIDA T32疼痛和物质使用计划 疾病，疼痛司的疼痛心理学和董事会认证的疼痛医生奖学金计划， 斯坦福大学奖学金的副教务长本科教育（VPUE），和她的多个积极的国家 国际研究合作。达纳尔博士将通过结合 个人和小组会议，协作指导，角色建模，并参与跨部门 讲座和国家会议。此外，她还将把她的学员紧密地融入斯坦福大学CTSA 导师计划和斯坦福大学教师多样性和发展办公室的广泛产品， 包括NIH K系列和R系列资助的密集写作项目。她的职业发展计划 包括数字健康设计培训，以优化数字行为治疗， 参与和反应，以及执行科学，阿片类药物政策和高级 斯坦福大学教师领导力项目的指导。达纳尔博士有很好的资源，很长时间- 长期成功的研究合作，以及大量积极的资金组合。建议的K24 研究和其他计划中的项目预计将导致新的方向和创新的研究， 疼痛和阿片类药物使用障碍的连续性，并显着有助于我们的科学理解， 这些残疾人的条件。Darnall博士将利用K24和她现有的资源， 培训下一代致力于开展有影响力的以患者为导向的研究的科学家。

Project Summary: The primary goals of this K24 application are to allow Beth Darnall, PhD to (1) provide high- quality and intensive mentorship of early-career investigators in patient-oriented research (POR); and (2) acquire new training in research methodologies to support expansion of digital health research in populations on the continuum of opioid use disorder. A K24 award will provide Dr. Darnall with the critical protected time for POR and mentoring that would otherwise be spent on administrative and clinical responsibilities. Dr. Darnall is Associate Professor and Director of the Stanford Pain Relief Innovations Lab at the Stanford University School of Medicine. Dr. Darnall proposes to extend her line of research on scalable digital behavioral medicine to people with comorbid chronic pain and prescription opioid misuse, and then conduct a national virtual randomized controlled trail to investigate impacts on pain and opioid outcomes. Her mentoring plan includes structured mentoring in: (1) designing and implementing POR studies; (2) preparing scientific papers and presentations; (3) writing and submitting successful research grant applications; (4) ethical and responsible conduct of research; and (5) professionalism and successful navigation of the academic process to achieve scientific independence. Trainees will be derived from multiple current sources including the Stanford Clinical and Translational Science Award (CTSA), the Pain Division's NIDA T32 program on pain and substance use disorder, the Pain Division's pain psychology and board certified pain physician fellowship programs, the Stanford fellowship for the Vice Provost for Undergraduate Education (VPUE), and her multiple active national and international research collaborations. Dr. Darnall will accomplish her mentoring plan through a combination of individual and group meetings, collaborative mentoring, role modeling, and participation in interdepartmental lectures and at national meetings. Additionally, she will closely integrate her mentees into the Stanford CTSA mentoring program and the extensive offerings of the Stanford Office for Faculty Diversity and Development, including the NIH K-series and R-series grant intensive writing programs. Her career development plan includes training in digital health design to optimize digital behavioral treatments for enhanced user engagement and response, as well as trainings in implementation science, opioid policy, and advanced mentoring from the Stanford Faculty Leadership Program. Dr. Darnall has outstanding resources, long- standing successful research collaborations, and a substantial active funding portfolio. The proposed K24 research and other planned projects are expected to lead to new directions and innovations in research on pain and the continuum of opioid use disorder, and significantly contribute to our scientific understanding of these disabling conditions. Dr. Darnall will leverage the K24 and her existing resources to provide crucial training to the next generation of scientists dedicated to conducting impactful patient-oriented research.