Microbial multi-stress responses: from intracellular networks to communities

项目摘要/摘要 细菌通过生理应激反应在恶劣或严酷的环境中生存。这些应激反应 塑造生活在我们体内、我们身上和周围的微生物群落。尽管压力反应很重要，但我们 对微生物如何耐受复杂的压力组合知之甚少。 这项提案将回答有关微生物应激反应的三个主要问题。1)做什么 细菌对多种应激源的反应？)压力如何重塑微生物的组成和稳定性 社区？3.)我们能以多快的速度了解新发现的细菌的压力反应？在回答中 这些问题，几个假设将使用一致的实验和理论框架进行评估。 致病性链球菌的应激反应网络将被描述在多个尺度上。从长远来看， 我们的目标是开发工具来分析和定位人类微生物群中复杂的应激反应。

Project Summary/Abstract Bacteria mount a physiologic stress response to survive hostile or stringent conditions. These stress responses shape the microbial communities that live in, on, and around us. Despite the importance of stress responses, we know little about how microbes tolerate complex combinations of stressors. This proposal will answer three overarching questions regarding microbial stress responses. 1.) How do bacteria response to multiple stressors? 2.) How does stress reshape the composition and stability of microbial communities? 3.) How quickly can we learn the stress responses of newly discovered bacteria? In answering these questions, several hypotheses will be evaluated using a consistent experimental and theoretical framework. The stress response networks of pathogenic streptococci will be characterized across multiple scales. Long term, our goal is to develop tools to analyze and target complex stress responses in the human microbiome.