Bacterial polycyclic aromatic hydrocarbon transport and degradation

细菌多环芳烃的转运和降解

• 批准号: DP210100553
• 负责人: A/Prof Karl Hassan
• 金额: $ 29.26万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-22 至 2024-02-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100553
• 关键词: Bacterial; polycyclic; aromatic; hydrocarbon; transport

This project aims to investigate the molecular processes underpinning the degradation of polycyclic aromatic hydrocarbons (PAHs) by bacteria. PAHs are persistent environmental contaminants linked to several human diseases, including cancer. Bacteria capable of degrading PAHs could be used to naturally and effectively reduce environmental PAH loads to below safe levels. The project will apply techniques in functional genomics and biochemistry to help define the ways that PAHs are taken up from the environment by bacteria, their fate within bacterial cells, and the ways that bacteria overcome the inherent toxicity of PAHs. The knowledge generated is expected to enhance our capacity to rationally deploy bacteria for PAH degradation.

本项目旨在研究细菌降解多环芳烃的分子过程。多环芳烃是与包括癌症在内的多种人类疾病有关的持久性环境污染物。能够降解多环芳烃的细菌可以用来自然和有效地减少环境中的多环芳烃负荷低于安全水平。该项目将应用功能基因组学和生物化学技术来帮助确定细菌从环境中吸收多环芳烃的方式，它们在细菌细胞内的命运，以及细菌克服多环芳烃固有毒性的方式。所产生的知识有望提高我们合理部署细菌降解PAH的能力。