Breaking through the Gram-negative cell barrier

突破革兰氏阴性细胞屏障

• 批准号: FT180100123
• 负责人: A/Prof Karl Hassan
• 金额: $ 61.31万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT180100123
• 关键词: Breaking; through; Gram; negative; cell

This project aims to develop fundamental knowledge of the cell envelope in Gram-negative bacteria, which functions as a permeability barrier to small molecules. Combining innovative functional genomics with biochemistry, this project will determine how small molecules can pass across the cell envelope, and the chemical properties that they need to do so. Some Gram-negative bacteria are human pathogens and cause serious infections, whereas others are used in biotechnology for biosynthetic chemical production or bioremediation. This project expects to help the future development of new antibiotics and assist in the design of strains to be used in biotechnological applications.

该项目旨在开发革兰氏阴性细菌细胞包膜的基础知识，其功能是小分子的渗透性屏障。该项目将创新的功能基因组学与生物化学相结合，将确定小分子如何穿过细胞包膜，以及它们需要的化学性质。一些革兰氏阴性菌是人类病原体，会引起严重感染，而另一些则用于生物合成化学品生产或生物修复的生物技术。该项目预计将帮助未来新抗生素的开发，并协助设计用于生物技术应用的菌株。