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Therapeutics Development Core (Core B)

治疗开发核心（核心B）

基本信息

批准号：
10203939
负责人：
Xunrong Luo
金额：
$ 24.16万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10203939
关键词：
Animal Model Biological Biological Sciences Blood Vessels Cell Therapy Cells Chemicals Chemistry Chronic Kidney Failure Clinical Clinical Trials Collaborations Consultations Development Developmental Process Developmental Therapeutics Program Diabetes Mellitus Diabetic Nephropathy Disease Doctor of Philosophy Drug Kinetics Drug Targeting End stage renal failure Feedback Funding Future Goals Hematology Hematopoietic Human In Vitro Income Infrastructure Institutes Intercept International Islets of Langerhans Kidney Kidney Diseases Licensing Life Medical Device Mentors Modality Molecular Nanotechnology Neurologic Organ Pathogenesis Pharmaceutical Preparations Phenotype Pre-Clinical Model Prevention Process Production Quality Control Recombinant Proteins Renal function Replacement Therapy Research Personnel Risk Route Services Supportive care System Testing Therapeutic Tissues Toxicology Translating Translations Transplantation Treatment Efficacy Universities Validation base clinical care clinical translation commercialization design drug discovery efficacy evaluation experience high throughput screening immunoregulation in vivo in vivo imaging in vivo monitoring innovation kidney repair nanomedicine novel novel therapeutics precision drugs product development programs regenerative therapy restoration scale up screening small molecule small molecule therapeutics stem cells synergism targeted treatment technology development therapeutic development therapeutic target tool virtual

项目摘要

PROJECT SUMMARY TO THERAPEUTICS DEVELOPMENT CORE The goal of the Therapeutics Development Core (Core B) is to establish an efficient platform for supporting the development and validation of a pipeline of chemical, biological, and cellular therapeutics for the treatment of a wide spectrum of kidney diseases. Northwestern University (NU) has been at the forefront of drug discovery for a wide range of diseases, and state-of-the-art infrastructures have been built that collectively have significantly expanded our therapeutics armamentarium for many diseases including hematological, oncological, neurological, and rheumatological conditions. However, they have not been prioritized and tailored to kidney-specific therapeutics development. We propose to fill this gap by establishing a Therapeutics Development Core within the NU-GoKIDNEY Center. The Therapeutics Development Core will function as an efficient translational conduit between the Preclinical Models Core (Core A) and the Clinical and Translational Core (Core C). This Core proposes to provide a “one-stop” shop for concierge services for access and expert guidance to kidney therapeutics development, with the ultimate goal of clinical translation. It will be constructed to provide centralized consultation services for developing novel kidney disease-specific therapeutics to the NU-GoKIDNEY Center investigators for: (1) designing and testing experimental biological and small molecule therapeutics; (2) designing and testing cellular therapeutics; and (3) designing and testing nanotechnology-based precision targeting of therapeutic “payloads” to the desired cells and tissues. Core B will implement a Ph.D.-level Navigator system for maximizing service efficiency and promoting innovative collaborations. Core B will also use the soon-to-be-launched nephro-HUB to expand the core user base, track core services, enhance user interactions and promote user collaborations. Core B Directors and Navigators collectively possess extensive expertise encompassing novel cellular therapeutics development, virtual drug and biologics design, high-throughput screening platforms for efficiency determination, and nanotechnology-based precision drug targeting. Core B will formalize and capture this collective expertise under one roof, and provide investigators of the NU-GoKIDNEY Center with superior customer service combined with expert guidance in choosing the most efficient route for novel therapeutics development. By providing these core services, we anticipate that the Therapeutics Development Core will: (1) accelerate kidney therapeutics development by providing target-specific consultations and navigation through the processes of therapeutics design, development, validation and production; (2) elevate kidney disease- specific therapeutics development to the forefront of existing cutting-edge expertise and state-of-the-art infrastructures in therapeutics development at Northwestern; (3) catalyze and synergize innovative collaborations within a dynamic network of NU-GoKIDNEY Center investigators via a common platform provided by the Therapeutics Development Core.

治疗学发展核心项目总结