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A multimodal approach to understanding the development of neurovascular coupling

了解神经血管耦合发展的多模式方法

基本信息

批准号：
10202746
负责人：
Patrick James Drew
金额：
$ 42.07万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-25 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10202746
关键词：
Adolescent Adult Affect Age Anesthesia procedures Animals Astrocytes Behavior Behavioral Biological Assay Blood Vessels Blood Volume Blood flow Brain Cardiovascular system Cerebrovascular Circulation Child Collaborations Conflict (Psychology)Coupling Development Developmental Process Electrophysiology (science)Functional Magnetic Resonance Imaging Human Image Infant Investigation Knowledge Laser Scanning Microscopy Locomotion Measures Motor Movement Mus Nature Near-infrared optical imaging Neonatal Neurodevelopmental Disorder Neurons Optics Pericytes Pharmacology Procedures Research Rest Rodent Role Scientist Sensory Signal Transduction Somatosensory Cortex Synapses Techniques Testing Vibrissae awake cardiovascular effects cognitive function constriction density experimental study hemodynamics imaging modality insight juvenile animal mouse model multimodality neural circuit neurodevelopment neuroimaging neurovascular coupling novel optical imaging postnatal development postnatal period relating to nervous system response two photon microscopy two-photon

项目摘要

Abstract: Hemodynamic signals allow us to non-invasively assay neural activity and could provide great insight into neural changes during postnatal development. However, it is not clearly understood how neural activity is related to changes in blood flow and oxygenation in the neonatal and juvenile brain. Previous studies in anesthetized animals and sedated humans have come to conflicting results as to the sign and magnitude of neurovascular coupling, and this unresolved issue has stalled the use of hemodynamic imaging in infants and children. In this proposal, we will determine how neurovascular coupling changes during postnatal development in the somatosensory cortex of the awake mouse brain, how this change in neurovascular coupling impacts BOLD fMRI signals, and how behavioral state can alter neurovascular coupling. We will use a multimodal approach, combining optical imaging (intrinsic optical signal imaging and 2-photon microscopy), electrophysiology, and fMRI to elucidate the relationship of hemodynamic signals to neural activity from the levels of single vessels up to the whole brain. We will mechanistically dissect the roles of local neural activity and cardiovascular effects on hemodynamic signals. The research proposed here will enable the use of hemodynamic imaging to study neural activity, plasticity, and neurodevelopmental disorders in infants and juvenile humans and animals.

翻译后摘要：血流动力学信号使我们能够非侵入性测定神经活动，并可以提供对出生后发育过程中的神经变化有很好的了解。然而，人们并不清楚新生儿和青少年的神经活动与血流和氧合变化的关系个脑袋以前在麻醉动物和镇静人类中的研究得出了相互矛盾的结果关于神经血管耦合的迹象和幅度，这个未解决的问题已经阻碍了使用婴儿和儿童的血流动力学成像。在本提案中，我们将确定如何出生后发育过程中大鼠躯体感觉皮层神经血管耦联的变化清醒的小鼠大脑，这种神经血管耦合的变化如何影响BOLD fMRI信号，以及如何行为状态可以改变神经血管耦合。我们将使用多模式方法，结合光学成像（内在光学信号成像和双光子显微镜），电生理学，和 fMRI从单个神经元水平阐明血流动力学信号与神经活动的关系血管一直延伸到整个大脑我们将机械地剖析局部神经活动的作用，对血液动力学信号的心血管效应。这里提出的研究将使使用研究婴儿神经活动、可塑性和神经发育障碍的血流动力学成像和幼年人类和动物。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neurovascular coupling and bilateral connectivity during NREM and REM sleep.

DOI：
10.7554/elife.62071
发表时间：
2020-10-29
期刊：
eLife
影响因子：
7.7
作者：
Turner KL;Gheres KW;Proctor EA;Drew PJ
通讯作者：
Drew PJ

Neurovascular coupling: motive unknown.

DOI：
10.1016/j.tins.2022.08.004
发表时间：
2022-11
期刊：
TRENDS IN NEUROSCIENCES
影响因子：
15.9
作者：
Drew, Patrick J.
通讯作者：
Drew, Patrick J.

Development of brain-wide connectivity architecture in awake rats.

DOI：
10.1016/j.neuroimage.2018.05.009
发表时间：
2018-08-01
期刊：
NeuroImage
影响因子：
5.7
作者：
Ma Z;Ma Y;Zhang N
通讯作者：
Zhang N

nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice.

DOI：
10.7554/elife.60533
发表时间：
2020-10-05
期刊：
eLife
影响因子：
7.7
作者：
Echagarruga CT;Gheres KW;Norwood JN;Drew PJ
通讯作者：
Drew PJ

Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.

DOI：
10.1038/s42003-023-05121-5
发表时间：
2023-07-17
期刊：
COMMUNICATIONS BIOLOGY
影响因子：
5.9
作者：
Gheres, Kyle W. W.;Unsal, Hayreddin S. S.;Han, Xu;Zhang, Qingguang;Turner, Kevin L. L.;Zhang, Nanyin;Drew, Patrick J. J.
通讯作者：
Drew, Patrick J. J.