Translational Research Training in Sleep Medicine

本申请是T32 HL082610《睡眠医学转化性研究培训》的第二次续展。 目前处于我们第二个五年资助期的第42个月。这项计划的广泛目标是训练未来 一代临床和基础研究人员以一种转化的方法来研究睡眠医学。在未来5年内 期间，我们建议将重点放在新兴的睡眠健康概念上-具体地说， 睡眠影响健康的机制，以及改善健康的睡眠干预措施的评估。我们的 哲学是，有效的睡眠医学研究培训包含翻译内容， 多学科教员，以及基于能力的成果。在这种理念的指导下，我们的培训计划 包括：主要关注有经验的、资金充足的睡眠医学研究人员的指导性研究； 团队指导，与代表互补内容和方法领域的共同导师一起，并仔细 评估导师和受训者的进展；教学工作，包括睡眠研究方法的迷你课程， 对当前文献的批判性评价、专业发展和负责任的研究行为； 可衡量的成果，包括学员出版物、演示文稿和赠款申请；个人和 准备职业发展奖申请的小组指导.个人规定 正规课程；以及获得哥伦比亚大学广泛的培训和研究支助资源 匹兹堡，包括临床和转化科学研究所(CTSI)。培训计划 包括两部分：1)为国家招聘的内科医生提供2-3年博士后培训奖学金 心理学、流行病学和神经科学专业的科学家和博士毕业生。我们建议 保持当前项目规模为4名博士后。2)医学生的研究经验， 包括两条路径：为期10周的暑期研究计划和纵向学术项目 通过四年的医学院学习。我们建议每年招收4名医学生参加这些项目。 在我们最初的8年半时间里，我们的实习生取得了相当大的成功：我们的14名博士后发表了 在培训期间平均有6.1篇同行评审的论文；12/14提交了F或K奖申请；以及 7/9完成审查程序的人(78%)获得了K奖。我们的影响力和成功 培训计划已经扩展到由睡眠指导的其他皮特项目的以睡眠为重点的博士后 医学培训教师：所有4名申请者(100%)都获得了职业发展奖。我们的16位医生 学生提交了12篇摘要，发表了8篇同行评议论文。我们已经系统地评估了 我们的计划包括我们的学员、大学顾问委员会和外部顾问委员会。基于这些 评估，我们建议进一步加强方案，更加结构化的导向，更早的评估 辅导者-辅导者“适合”，简化的会议和教育计划，技术辅助的多 机构讲习班，并加强招聘MD和代表性不足的少数族裔受训人员。

This application is the second renewal of T32 HL082610, “Translational Research Training in Sleep Medicine,” currently in Month 42 of our second 5-year grant period. The broad aim of this program is to train the future generation of clinical and basic researchers in a translational approach to sleep medicine. For the next 5-year period, we propose to sharpen our focus on the emerging concept of sleep health—specifically, on the mechanisms whereby sleep influences health, and the evaluation of sleep interventions to improve health. Our philosophy is that effective research training in sleep medicine incorporates translational content, multidisciplinary faculty, and competency-based outcomes. Guided by this philosophy, our training program includes: A primary focus on mentored research with experienced, well-funded sleep medicine investigators; Team mentoring, with co-mentors representing complementary content and methodologic areas, and careful evaluation of mentor and mentee progress; Didactic work including mini-courses in sleep research methods, critical appraisal of current literature, professional development, and responsible conduct of research; Measurable outcomes, including trainee publications, presentations, and grant applications; Individual and group instruction in the preparation of career development award applications; Individually-prescribed formal coursework; and access to the broad training and research support resources of the University of Pittsburgh, including those of the Clinical and Translational Science Institute (CTSI). The training program includes two components: 1) A 2-3 year postdoctoral training fellowship for nationally-recruited physician scientists and PhD graduates of psychology, epidemiology, and neuroscience programs. We propose to maintain the current program size of 4 postdocs. 2) Research experiences for medical students, which comprise two pathways: a 10-week Summer Research Program and a Longitudinal Scholarly Project running through four years of medical school. We propose to enroll 4 medical students each year in these programs. During our initial 8½ years, our trainees have enjoyed considerable success: Our 14 postdocs have published an average of 6.1 peer-reviewed papers during training; 12/14 have submitted F or K Award applications; and 7/9 who have completed the review process (78%) have received K awards. The influence and success of our training program has extended to sleep-focused postdocs in other Pitt programs who are mentored by Sleep Medicine training faculty: All 4 who applied (100%) received career development awards. Our 16 medical students have submitted 12 abstracts and published 8 peer-reviewed papers. We have systematically evaluated our program with our trainees, University Advisory Board, and External Advisory Board. Based on these evaluations, we propose to further strengthen the program with more structured orientation, earlier evaluation of mentor-mentee “fit,” streamlined meetings and educational programs, technology-assisted multi- institutional workshops, and enhanced recruitment of MD and under-represented minority trainees.