Translational Research Training in Sleep Medicine

描述(申请人提供)：这是T32 HL082610的修订申请，“睡眠医学中的转化性研究培训”。作为对先前审查的回应，我们重新组织了项目主管，增加了经验丰富的生物统计学家导师，并解决了每个审查人员的其他意见。该计划的目标是培训未来一代临床和基础研究人员在睡眠医学的翻译方法。睡眠障碍会在心肺、新陈代谢和神经系统中产生广泛的疾病。尽管最近在睡眠和昼夜节律的基础科学方面取得了科学突破，但很少有受过睡眠医学翻译科学培训的面向临床的研究人员。制定成功的转化性睡眠医学培训计划需要一个强有力的多学科合作的基础，以代表该领域的科学观点的多样性。匹兹堡大学就有这样的合作。来自医学院内三个学院(医学、公共卫生、护理)和六个部门(精神病学、肺部医学、肾脏医学、神经病学、行为医学、神经科学)的大量合作研究人员目前正在接受外部资助，用于睡眠研究。此外，该大学在睡眠研究方面拥有出色的基础设施和学术资源，包括临床神经科学研究中心、睡眠和昼夜节律实验室、流行病学系内的两个现场中心，以及专门研究睡眠障碍动物模型的基础研究实验室。该培训计划的主要重点将是博士后培训，其次是有指导的医学生研究。该大学的教员和资源最初将每年培训两名博士后研究员，到第三年增加到四名受训人员。该计划主要面向从肺部医学、精神病学、神经病学和内科领域招募的医学博士科学家。培训计划的核心将是一种有指导的研究体验，它将是多学科的，以翻译为重点，以对睡眠生理学的透彻理解为基础，并以绩效里程碑为基础。该计划将包括最初沉浸在为期八周的动物和人类睡眠生理学的“基本培训”课程中，持续强调展示和发表研究成果，个人规定的课程作业，以及准备职业发展奖(K系列应用程序)。该计划将包括对实习生和教师导师的预定反馈和评估，并将由一个由系主任和其他T32计划主任组成的研究顾问小组以及外部顾问委员会监督。医学生的研究体验是为了特别激发人们对睡眠医学的兴趣，并在更广泛的意义上解决翻译研究面临的关键“管道”问题。

DESCRIPTION (provided by applicant): This is a revised application of T32 HL082610, "Translational Research Training in Sleep Medicine." In response to the previous review, we have reorganized the Program directorship, added experienced biostatistician mentors, and addressed each of the reviewers' other comments. The goal of this Program is to train the future generation of clinical and basic researchers in a translational approach to Sleep Medicine. Sleep disturbances produce wide-ranging morbidities in cardiopulmonary, metabolic, and neurological systems. Despite recent scientific breakthroughs in the basic science of sleep and circadian rhythms, there are few clinically-oriented investigators trained in the translational science of Sleep Medicine. Developing a successful training program in translational Sleep Medicine requires a foundation of vigorous multidisciplinary collaborations to represent the diversity of scientific perspectives in the field. Such collaborations exist at the University of Pittsburgh. A critical mass of collaborating researchers from three schools (Medicine, Public Health, Nursing) and six Departments or Divisions within the School of Medicine (Psychiatry, Pulmonary Medicine, Renal Medicine, Neurology, Behavioral Medicine, Neuroscience) currently receive external funding for sleep research. In addition, the University has an outstanding infrastructure and academic resources in sleep research including the Clinical Neuroscience Research Center, the Sleep and Circadian Rhythms Laboratory, two field centers within the Department of Epidemiology, and a basic research laboratory specializing in animal models of sleep disorders. The Training Program's primary focus will be on post-doctoral training, with a secondary focus on mentored medical student research. The faculty and resources of the University will initially train two postdoctoral fellows per year, building to four trainees by the third year. The Program is intended primarily for M.D. scientists recruited from the fields of Pulmonary Medicine, Psychiatry, Neurology, and Internal Medicine. The core of the Training Program will be a mentored research experience that will be multidisciplinary in nature, translational in focus, grounded in a thorough understanding of sleep physiology, and structured by performance-based milestones. The Program will feature initial immersion in an eight week "basic training" course in animal and human sleep physiology, ongoing emphasis on presentation and publication of research findings, individually-prescribed coursework, and preparation of a career development award (K-series applications). The Program will include scheduled feedback and evaluation of both trainees and faculty mentors, and will be overseen by a Research Advisory Group consisting of Department Chairs and other T32 Program Directors, as well as an External Advisory Board. The medical student research experiences are designed to stimulate interest in Sleep Medicine specifically, and to address the critical "pipeline" issue facing translational research in a more general sense.