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Maternal exposure to childhood abuse and disparities in offspring neurodevelopment:Effects of COVID-19 pandemic-related stress

Maternal exposure to childhood abuse and disparities in offspring neurodevelopment:Effects of COVID-19 pandemic-related stress
母亲童年遭受虐待和后代神经发育差异:COVID-19 大流行相关压力的影响
批准号:
10208070
负责人:
Andrea Roberts
金额:
$57.41万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-01-01 至 2023-12-31
关键词:
2019-nCoVAddressAdministrative SupplementAdultAdverse eventAffectAntibodiesAnxietyAttention Deficit DisorderAwardBiologicalBiological AssayBiological MarkersBirthBloodBrainCOVID-19COVID-19 pandemicCessation of lifeChildChild AbuseChild DevelopmentChild RearingClinicalCollectionConceptionsDataData CollectionDevelopmentEconomicsEndocrineEnrollmentEnsureExhibitsExposure toFemale of child bearing ageFinancial HardshipFrightFunctional disorderFutureGenerationsHealthHealth Care SectorHormonalImpairmentInfectionInflammationLife Cycle StagesLinkLonelinessLow Birth Weight InfantMaternal ExposureMaternal and Child HealthMeasuresMental DepressionMissionModelingNational Institute of Child Health and Human DevelopmentNeurodevelopmental DeficitNewborn InfantNurses&apos Health StudyOccupational ExposureOccupationsOutcomeParentsParticipantPopulationPre-EclampsiaPregnancyPregnancy ComplicationsPregnant WomenPremature BirthProspective cohortReactionRecording of previous eventsRecrudescencesResearchRiskRisk FactorsSamplingSeveritiesSeverity of illnessSocial isolationSpecimenStressSymptomsSystemTestingTimeVaccinesViralVirus DiseasesVulnerable PopulationsWomanadverse event riskautism spectrum disordercohortcoronavirus diseasedesignexperiencehigh riskhypothalamic-pituitary-adrenal axishypothalamic-pituitary-thyroid axisloved onesmemberneurodevelopmentneurodevelopmental effectoffspringpandemic diseaseparent grantprematureprenatal interventionprepregnancyprospectivepsychologicpublic health interventionresponsestressor

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PROJECT SUMMARY Children of women exposed to childhood abuse exhibit increased risk for a wide array of neurodevelopmental deficits and are at elevated risk of anxiety, depression, autism, and attention deficit disorder (ADHD). The parent grant seeks to identify biological dysregulation during pregnancy that may cause this increased risk. Inflammation and hormonal dysregulation harms offspring neurodevelopment and is present in adults who have experienced childhood abuse, yet it is unknown whether dysregulation in these systems continues during the pregnancies of women exposed to abuse, the critical time for effects on offspring brains. The parent grant collects biological samples during pregnancy to measure inflammation and hormonal dysregulation in a large, prospective cohort of women. Women with histories of childhood abuse experience more stressors during pregnancy, and Aim 2 of the parent grant posits that these stressors may partially account for pregnancy biological dysregulation. In this administrative supplement, we propose to augment the study to capture key and time sensitive data on the COVID-19 pandemic. We hypothesize that pandemic-related adverse events and stress will be more common in women exposed to child abuse and will increase risk for biological dysregulation during pregnancy that is harmful to offspring development. Adverse events during pregnancy and psychological reactions to them have been linked to pregnancy complications, prematurity, low birth weight, and offspring neurodevelopmental deficits. Vulnerable populations, including women exposed to childhood abuse, are likely to experience more of these adverse events and be more negatively impacted by them. Forecasting models suggest that in the absence of a vaccine, SARS-CoV-2 is likely to continue circulating for the foreseeable future, highlighting the urgent need for robust research on the long-term health effects of the pandemic on pregnant women and their offspring. Participants enrolled via the parent award are members of the Nurses' Health Study 3, and most are clinically active, thus this study has the advantage of having direct access to a large population with high risk of occupational exposure to SARS-CoV-2. At the same time, they are vulnerable to healthcare sector downsizing and job loss, making the cohort ideal for studying the effects of pandemic-related stressors on pregnancy and birth outcomes. The supplement will collect data on COVID-19-related adverse events and COVID-19-related stress at both pre-pregnancy and pregnancy, including fear of infection, financial stress, pandemic-related depression, parenting stress, and illness and death of loved ones. This research will address the NICHD's core mission to ensure that “all children have the chance to achieve their full potential for healthy and productive lives” by identifying factors, “starting before conception, [that] can influence development across the life course and across generations.”
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Maternal Exposure to Childhood Abuse and Disparities in Offspring Neurodevelopment: Identifying Mechanisms
  • 批准号:
    10380833
  • 项目类别:
  • 资助金额:
    $66.17万
  • 财政年份:
    2019
  • 负责人:
    Andrea Roberts
  • 依托单位:
海外基金