K-CORE: Curation and Knowledge Management for SPARC

K-CORE：SPARC 的策划和知识管理

• 批准号: 10214948
• 负责人: MARYANN E MARTONE
• 金额: $ 167.92万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-04 至 2024-09-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10214948
• 关键词: 3-Dimensional; Anatomy; Autonomic nervous system; Bioinformatics; Data; Data Set; Enteric Nervous System; Information Resources Management; Institutes; Knowledge; Maps; Motor Pathways; Semantics; Sensory; Services; Sympathetic Nervous System; base; data resource; knowledge graph; simulation; technology development; tool

This proposal outlines plans for the creation of K-CORE, a new core for SPARC that will provide curation of SPARC datasets, knowledge management and services for the SPARC Knowledge Graph. The latter is a semantic store that combines information on SPARC datasets annotated according to the SPARC Minimal Information Standard (MIS) with functional and anatomical topologically based connectivity knowledge for the autonomic nervous system (ANS). Included in the ANS are the sympathetic, parasympathetic and enteric nervous systems, with reference to sensory and motor pathways as necessary. Technology development in SPARC is provided by the SPARC Data and Resource Center (DRC), currently comprising DAT-CORE, which provisions the data platform, MAP-CORE, which develops 2 and 3D mapping tools and a map-based GUI, and SIM-CORE which fields the simulation platform. To date, the curation and knowledge management functions have been conducted under the purview of MAP-CORE, led by Dr. Peter Hunter at the Auckland Bioinformatics Institute with a subcontract to UCSD. However, these services are sufficiently broad and cross cutting that they should be managed through a separate core. The K-CORE team has been providing curation and knowledge management services for SPARC since 2018 and thus are deeply familiar with the project.

该提案概述了创建K-CORE的计划，K-CORE是一个新的核心，将提供 为联合国开发计划署管理数据集、知识管理和服务 Graph.后者是一个语义存储库，它组合了标注的XML数据集上的信息 根据最小信息标准（MIS）， 自主神经系统（ANS）的基于拓扑的连接性知识。列入 ANS是交感神经、副交感神经和肠神经系统， 感觉和运动通路。技术开发在中国是由 数据和资源中心（DRC），目前包括DAT-CORE，它提供 数据平台MAP-CORE，用于开发二维和三维绘图工具以及基于地图的GUI， SIM-CORE作为仿真平台。到目前为止， 管理职能在彼得博士领导的MAP-CORE的职权范围内进行 亨特在奥克兰生物信息学研究所与一个学生到加州大学圣地亚哥分校。但这些 这些服务足够广泛和交叉，因此应通过一个单独的 核心K-CORE团队一直为以下项目提供策展和知识管理服务： 自2018年以来，他一直在工作，因此对该项目非常熟悉。