Synthesizing Best Practice to Accelerate Access to Emerging HIV Prevention Modalities

7.项目摘要 该项目是对《综合最佳做法以加速获得新的艾滋病毒预防措施》的补充 模式。母项目采用实施科学方法来支持联邦 通过发展生物行为基础设施（即，经验上的严谨知识， 指导方针，工具），将支持扩大有效的PrEP交付计划，并促进健康公平， 传播新的生物医学艾滋病毒预防战略。该补充旨在进行 合作，实施科学研究，既将加强EHE活动在HRSA资助的卫生 中心，并制定一套统一的实践知情，程序级指标，以方便比较 在不同环境和司法管辖区的实施进展。该补充是与东南部合作 艾滋病教育和培训中心（SE AETC），这是一个由HRSA资助的机构，专注于培训、技术 支持，并在组成东南地区的八个州实施转型。协同 SE AETC，该补充将收集来自东南地区接受HRSA资助的五家诊所的数据 根据HRSA 20-091进行艾滋病毒预防，并将这些数据与从10个诊所收集的数据进行比较， 通过不同的SE AETC倡议获得艾滋病毒预防计划的资金。该补充剂结合 SE AETC的实践和以社区为中心的专业知识，以及研究和实施科学 专家的母项目，以实现以下具体目标：（1）指定一套统一的过程 （2）制定一套与项目实施和评估最相关的指标和成果指标; 统一的衡量标准，以衡量艾滋病毒预防实施逻辑模型的其他关键组成部分;（3）制定 并为这些统一的指标试行一个基于网络的统一数据收集和管理系统， 自动报告和可视化表示程序性能，最大限度地减少合作伙伴诊所站点的负担; （4）研究决定因素、实施战略、机制和结果之间的关系 为了更好地了解如何以及在何种条件下预防艾滋病毒， 最有效地实现预期的结果。拟议项目有可能产生重大影响， 不仅对合作临床研究中心的数据收集和分析产生影响，还对更大范围的数据协调产生影响 以及NIH和HRSA之间的实施科学合作。我们的项目特别关注 美国东南部地区，该国艾滋病毒新感染者的负担过重。这 实践驱动型实施科学研究对于支持联邦机构的数据驱动， 维持EHE投资影响所需的战略决策过程。

7. PROJECT SUMMARY This project is a supplement to Synthesizing Best Practice to Accelerate Access to Emerging HIV Prevention Modalities. The parent project applies an implementation science approach to support the federal Ending the HIV Epidemic “protect” goal by developing biobehavioral infrastructure (i.e., empirically rigorous knowledge, guidelines, tools) that will support expansion of effective PrEP delivery programs and promote health equity in the dissemination of emerging biomedical HIV prevention strategies. This supplement is designed to conduct collaborative, implementation science research that will both enhance EHE activities at HRSA-funded health centers and develop a unified set of practice-informed, program-level metrics to facilitate comparison of implementation progress across settings and jurisdictions. The supplement is a collaboration with the Southeast AIDS Education and Training Center (SE AETC), which is a HRSA-funded agency focused on training, technical support, and practice transformation in the eight states that comprise the Southeast region. In collaboration with SE AETC, this supplement will collect data from five clinics in the Southeast region that received HRSA funding for HIV prevention under HRSA 20-091, and will compare these data to those collected from ten clinics that receive funding for HIV prevention programs through a different SE AETC initiative. The supplement combines the practice and community-focused expertise of the SE AETC with the research and implementation science expertise of the parent project, in order to achieve the following specific aims: (1) Specify a unified set of process and outcome metrics most relevant for both program implementation and evaluation; (2) Operationalize a set of unified metrics to measure other critical components of HIV prevention implementation logic models; (3) Develop and pilot a web-based, uniform data collection and management system for these unified metrics that would automate reports and visual representation of program performance with minimal burden on partner clinic sites; and (4) Examine the association among determinants, implementation strategies, mechanisms, and outcomes across partner clinical sites in order to better understand how and under what conditions HIV prevention programs most effectively achieve desired outcomes. The proposed project has the potential to have a significant impact, not only on data collection and analysis at the partner clinical sites, but also for larger data harmonization and implementation science collaboration between NIH and HRSA. Our project focuses specifically on the Southeast region of the U.S., which bears a disproportionate burden of new HIV infections in the country. This type of practice-driven implementation science research is vital to supporting federal agencies in the data-driven, strategic decision-making process necessary to sustain the impact of the EHE investment.