Synthesizing Best Practice to Accelerate Access to Emerging HIV Prevention Modalities

7. 项目概要 该项目是对综合最佳实践以加速获得新兴艾滋病毒预防的补充 方式。父项目应用实施科学方法来支持联邦结束 通过发展生物行为基础设施（即严格的经验知识、 指南、工具），将支持扩大有效的 PrEP 实施计划并促进卫生公平 传播新兴的生物医学艾滋病毒预防策略。本补充旨在进行 协作、实施科学研究，将增强 HRSA 资助的卫生部门的 EHE 活动 中心并开发一套统一的、基于实践的、项目级的指标，以方便比较 跨环境和司法管辖区的实施进展。该增刊是与东南部合作的 艾滋病教育和培训中心 (SE AETC)，这是一个由 HRSA 资助的机构，专注于培训、技术 支持并实践东南地区八个州的转型。与合作 SE AETC，本补充材料将收集来自东南地区接受 HRSA 资助的五家诊所的数据 根据 HRSA 20-091 进行艾滋病毒预防，并将这些数据与从十家诊所收集的数据进行比较 通过不同的 SE AETC 计划获得艾滋病毒预防计划的资金。该补充品结合了 SE AETC 的实践和以社区为中心的专业知识以及研究和实施科学 母项目的专业知识，以实现以下具体目标：（1）指定一套统一的流程 以及与计划实施和评估最相关的成果指标； (2) 实施一套 衡量艾滋病毒预防实施逻辑模型其他关键组成部分的统一指标； (3) 开发 并针对这些统一指标试行基于网络的统一数据收集和管理系统 自动化报告和项目绩效的可视化表示，对合作诊所站点的负担最小； (4) 检查决定因素、实施策略、机制和结果之间的关联 跨合作临床中心，以便更好地了解如何以及在什么条件下预防艾滋病毒 计划最有效地实现预期成果。拟议的项目有可能产生重大影响 不仅对合作伙伴临床中心的数据收集和分析产生影响，而且对更大的数据协调产生影响 NIH 和 HRSA 之间的实施科学合作。我们的项目特别关注 美国东南部地区承担着该国新发艾滋病毒感染的不成比例的负担。这个 实践驱动型实施科学研究对于支持联邦机构进行数据驱动型、 维持 EHE 投资影响所需的战略决策过程。

7. PROJECT SUMMARY This project is a supplement to Synthesizing Best Practice to Accelerate Access to Emerging HIV Prevention Modalities. The parent project applies an implementation science approach to support the federal Ending the HIV Epidemic “protect” goal by developing biobehavioral infrastructure (i.e., empirically rigorous knowledge, guidelines, tools) that will support expansion of effective PrEP delivery programs and promote health equity in the dissemination of emerging biomedical HIV prevention strategies. This supplement is designed to conduct collaborative, implementation science research that will both enhance EHE activities at HRSA-funded health centers and develop a unified set of practice-informed, program-level metrics to facilitate comparison of implementation progress across settings and jurisdictions. The supplement is a collaboration with the Southeast AIDS Education and Training Center (SE AETC), which is a HRSA-funded agency focused on training, technical support, and practice transformation in the eight states that comprise the Southeast region. In collaboration with SE AETC, this supplement will collect data from five clinics in the Southeast region that received HRSA funding for HIV prevention under HRSA 20-091, and will compare these data to those collected from ten clinics that receive funding for HIV prevention programs through a different SE AETC initiative. The supplement combines the practice and community-focused expertise of the SE AETC with the research and implementation science expertise of the parent project, in order to achieve the following specific aims: (1) Specify a unified set of process and outcome metrics most relevant for both program implementation and evaluation; (2) Operationalize a set of unified metrics to measure other critical components of HIV prevention implementation logic models; (3) Develop and pilot a web-based, uniform data collection and management system for these unified metrics that would automate reports and visual representation of program performance with minimal burden on partner clinic sites; and (4) Examine the association among determinants, implementation strategies, mechanisms, and outcomes across partner clinical sites in order to better understand how and under what conditions HIV prevention programs most effectively achieve desired outcomes. The proposed project has the potential to have a significant impact, not only on data collection and analysis at the partner clinical sites, but also for larger data harmonization and implementation science collaboration between NIH and HRSA. Our project focuses specifically on the Southeast region of the U.S., which bears a disproportionate burden of new HIV infections in the country. This type of practice-driven implementation science research is vital to supporting federal agencies in the data-driven, strategic decision-making process necessary to sustain the impact of the EHE investment.