课题基金 / 基金详情

SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP
支持开展研究以评估藤黄果对 NTP 的毒理学潜力
批准号:
10213574
负责人:
BARNEY SPARROW
金额:
$70.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-26 至 2020-09-25

项目摘要

项目成果

BARNEY SPARROW的其他基金

相关文献

中文摘要
翻译
藤黄果提取物(GCE)被提名进行测试,因为它被广泛用于辅助饮食,而且缺乏足够的毒性数据。它是2016年美国第六大畅销膳食补充剂(Smith et al., 2017)。GCE是由藤黄果皮(从藤黄果重新命名)制成的,含有GCE的产品作为不含麻黄的饮食辅助产品销售。据称GCE的作用包括食欲抑制,抑制脂质合成和通过生热燃烧脂肪。一般情况下,GCE作为减肥补充剂的使用是在餐前服用胶囊,每天三次,总剂量约为4,500-6,000 mg/天(60 kg的人约为75-100 mg/kg/天)。由于推荐的GCE治疗方案(每天3次与食物一起服用)以及印度菜中藤黄作为一种成分的传统用法,选择了剂量饲料作为给药途径,而不是口服灌胃,后者通常与草药试验品一起使用,并提供每日丸剂剂量。在本年度,编写和审查了该研究的实验室报告草案,目前正在最后确定这些报告
英文摘要
Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized
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Production of TempOSeq data for the DrugMatrix reference library
  • 批准号:
    10710454
  • 项目类别:
  • 资助金额:
    $110.04万
  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位:
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) Phase 2
  • 批准号:
    10213572
  • 项目类别:
  • 资助金额:
    $100.0万
  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位:
Evaluation of HepaRG cells as a screen for chemical toxicity and assay optimization
  • 批准号:
    10700772
  • 项目类别:
  • 资助金额:
    $3.76万
  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位: