SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

藤黄果提取物（GCE）被提名进行测试，因为它被广泛用于辅助饮食，而且缺乏足够的毒性数据。它是2016年美国第六大畅销膳食补充剂（Smith et al., 2017）。GCE是由藤黄果皮（从藤黄果重新命名）制成的，含有GCE的产品作为不含麻黄的饮食辅助产品销售。据称GCE的作用包括食欲抑制，抑制脂质合成和通过生热燃烧脂肪。一般情况下，GCE作为减肥补充剂的使用是在餐前服用胶囊，每天三次，总剂量约为4,500-6,000 mg/天（60 kg的人约为75-100 mg/kg/天）。由于推荐的GCE治疗方案（每天3次与食物一起服用）以及印度菜中藤黄作为一种成分的传统用法，选择了剂量饲料作为给药途径，而不是口服灌胃，后者通常与草药试验品一起使用，并提供每日丸剂剂量。在本年度，编写和审查了该研究的实验室报告草案，目前正在最后确定这些报告

Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized