SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

支持开展研究以评估藤黄果对 NTP 的毒理学潜力

• 批准号: 10213574
• 负责人: BARNEY SPARROW
• 金额: $ 70万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2020-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213574
• 关键词: Amniotic Fluid; Body Weight decreased; Bolus Infusion; Cytology; Data; Desire for food; Diet; Dose; Ephedra; Evaluation; Fetus; Food; Fruit; Garcinia; Garcinia cambogia; Laboratories; Lipids; Mus; Oral; Persons; Plasma; Pregnancy; Rattus; Regimen; Reporting; Route; Sampling; Sperm Count Procedure; Sperm Motility; Testing; Thermogenesis; Time; Tissues; Toxic effect; Toxicology; Vagina; base; dietary supplements; exposed human population; fat burning; sperm analysis

Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized

藤黄提取物(GCE)被提名进行测试，因为它被广泛用作饮食辅助剂，但缺乏足够的毒性数据。它在2016年美国最畅销的膳食补充剂中排名第六(Smith等人，2017年)。GCE是从藤黄果胶(更名为藤黄)的果皮中制备的，含有GCE的产品作为不含麻黄的减肥辅助剂在市场上销售。据称，GCE的作用包括抑制食欲、抑制脂肪合成和通过产热来燃烧脂肪。通常，使用GCE作为减肥补充剂是通过每天三次饭前服用的片剂，总剂量约为每天4500-6000毫克(60公斤的人每天约为75-100毫克/公斤)。由于推荐的GCE方案(每天3次与食物一起服用)以及传统上将藤黄作为印度菜肴的配料使用，剂量饲料被选为给药途径，而不是口服灌胃，后者通常与草药测试文章一起使用，并提供每日推注剂量。在本年度内，编写和审查了研究的实验室报告草稿，目前正在最后定稿