SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP
支持开展研究以评估藤黄果对 NTP 的毒理学潜力
基本信息
- 批准号:10213574
- 负责人:
- 金额:$ 70万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-26 至 2020-09-25
- 项目状态:已结题
- 来源:
- 关键词:Amniotic FluidBody Weight decreasedBolus InfusionCytologyDataDesire for foodDietDoseEphedraEvaluationFetusFoodFruitGarciniaGarcinia cambogiaLaboratoriesLipidsMusOralPersonsPlasmaPregnancyRattusRegimenReportingRouteSamplingSperm Count ProcedureSperm MotilityTestingThermogenesisTimeTissuesToxic effectToxicologyVaginabasedietary supplementsexposed human populationfat burningsperm analysis
项目摘要
Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized
藤黄提取物(GCE)被提名进行测试,因为它被广泛用作饮食辅助剂,但缺乏足够的毒性数据。它在2016年美国最畅销的膳食补充剂中排名第六(Smith等人,2017年)。GCE是从藤黄果胶(更名为藤黄)的果皮中制备的,含有GCE的产品作为不含麻黄的减肥辅助剂在市场上销售。据称,GCE的作用包括抑制食欲、抑制脂肪合成和通过产热来燃烧脂肪。通常,使用GCE作为减肥补充剂是通过每天三次饭前服用的片剂,总剂量约为每天4500-6000毫克(60公斤的人每天约为75-100毫克/公斤)。由于推荐的GCE方案(每天3次与食物一起服用)以及传统上将藤黄作为印度菜肴的配料使用,剂量饲料被选为给药途径,而不是口服灌胃,后者通常与草药测试文章一起使用,并提供每日推注剂量。在本年度内,编写和审查了研究的实验室报告草稿,目前正在最后定稿
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BARNEY SPARROW其他文献
BARNEY SPARROW的其他文献
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{{ truncateString('BARNEY SPARROW', 18)}}的其他基金
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为 DrugMatrix 参考库生成 TempOSeq 数据
- 批准号:
10710454 - 财政年份:2017
- 资助金额:
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10700772 - 财政年份:2017
- 资助金额:
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多种测试药物对大鼠功能性心血管变化的评价
- 批准号:
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- 资助金额:
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10026342 - 财政年份:2017
- 资助金额:
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NTP Study Conducted at NIOSH- Evaluation of the Subchronic Toxicity of a Satratoxin Producing Chemotype Strain of Stachybotrys Chartarum
NIOSH 进行的 NTP 研究 - 产 Satratoxin 的 Stachybotrys Chartarum 化学型菌株的亚慢性毒性评估
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9795258 - 财政年份:2017
- 资助金额:
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- 批准号:
10700771 - 财政年份:2017
- 资助金额:
$ 70万 - 项目类别:
Evaluation of multiple test agents for functional cardiovascular changes in rats
多种测试药物对大鼠功能性心血管变化的评价
- 批准号:
10710453 - 财政年份:2017
- 资助金额:
$ 70万 - 项目类别:
Evaluation and use of 2D and 3D HepaRG cells to screen for chemical toxicity
评估和使用 2D 和 3D HepaRG 细胞筛选化学毒性
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- 资助金额:
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