SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

支持开展研究以评估藤黄果对 NTP 的毒理学潜力

• 批准号: 10213574
• 负责人: BARNEY SPARROW
• 金额: $ 70万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2020-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213574
• 关键词: Amniotic Fluid; Body Weight decreased; Bolus Infusion; Cytology; Data; Desire for food; Diet; Dose; Ephedra; Evaluation; Fetus; Food; Fruit; Garcinia; Garcinia cambogia; Laboratories; Lipids; Mus; Oral; Persons; Plasma; Pregnancy; Rattus; Regimen; Reporting; Route; Sampling; Sperm Count Procedure; Sperm Motility; Testing; Thermogenesis; Time; Tissues; Toxic effect; Toxicology; Vagina; base; dietary supplements; exposed human population; fat burning; sperm analysis

Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized

藤黄果提取物（GCE）被提名为基于其广泛用作饮食援助和缺乏足够毒性数据的测试。这是2016年美国第六种最畅销的饮食补充剂（Smith等，2017）。 GCE是由藤黄果（Garcinia Gummi-Gutta）（从藤黄果更名）的水果的果皮中制备的，含有GCE的产品被销售为无麻质的饮食辅助工具。 GCE的据称作用包括食欲抑制，抑制脂质合成以及通过热生成燃烧脂肪。通常，将GCE用作减肥补充剂的使用是每天三次在饭前服用的囊，导致总剂量约为4,500-6,000 mg/天（60公斤人群约75-100 mg/kg/kg/kg/kg/kg/kg/kg）。由于推荐的GCE方案（每​​天使用食物3次）以及藤黄作为印度美食的一种成分，因此被选为剂量喂食作为给药途径，而不是口服饲料，而口服饲料通常是在草药测试中使用的，并每天递送大量的大球剂量。在本年度，准备和审查了研究草案，目前正在确定报告