课题基金 / 基金详情

SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP
支持开展研究以评估藤黄果对 NTP 的毒理学潜力
批准号:
10213574
负责人:
BARNEY SPARROW
金额:
$70.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-26 至 2020-09-25

项目摘要

项目成果

BARNEY SPARROW的其他基金

相关文献

中文摘要
翻译
藤黄提取物(GCE)被提名进行测试,因为它被广泛用作饮食辅助剂,但缺乏足够的毒性数据。它在2016年美国最畅销的膳食补充剂中排名第六(Smith等人,2017年)。GCE是从藤黄果胶(更名为藤黄)的果皮中制备的,含有GCE的产品作为不含麻黄的减肥辅助剂在市场上销售。据称,GCE的作用包括抑制食欲、抑制脂肪合成和通过产热来燃烧脂肪。通常,使用GCE作为减肥补充剂是通过每天三次饭前服用的片剂,总剂量约为每天4500-6000毫克(60公斤的人每天约为75-100毫克/公斤)。由于推荐的GCE方案(每天3次与食物一起服用)以及传统上将藤黄作为印度菜肴的配料使用,剂量饲料被选为给药途径,而不是口服灌胃,后者通常与草药测试文章一起使用,并提供每日推注剂量。在本年度内,编写和审查了研究的实验室报告草稿,目前正在最后定稿
英文摘要
Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Production of TempOSeq data for the DrugMatrix reference library
  • 批准号:
    10710454
  • 项目类别:
  • 资助金额:
    $110.04万
  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位:
Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) Phase 2
  • 批准号:
    10213572
  • 项目类别:
  • 资助金额:
    $100.0万
  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位:
Evaluation of HepaRG cells as a screen for chemical toxicity and assay optimization
  • 批准号:
    10700772
  • 项目类别:
  • 资助金额:
    $3.76万
  • 财政年份:
    2017
  • 负责人:
    BARNEY SPARROW
  • 依托单位: