Support for the Conduct of Studies to Evaluate the Impact of Genetic Background and Potential Treatments of SARS-CoV-2 Induced Pneumonia

支持开展研究以评估遗传背景的影响和 SARS-CoV-2 引起的肺炎的潜在治疗方法

• 批准号: 10700771
• 负责人: BARNEY SPARROW
• 金额: $ 5万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2023-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10700771
• 关键词: 2019-nCoV; Acute Respiratory Distress Syndrome; Affect; COVID-19; COVID-19 pneumonia; COVID-19 treatment; Complication; Disease; Elderly; Genetic; High Prevalence; Individual; Intensive Care; Lung; Medical; Mus; Patients; Pneumonia; Respiratory Failure; novel; severe COVID-19

COVID19 is a novel zoonosis which has the potential for severe complications. Approximately 20% of affected individuals develop severe pneumonia progressing to acute respiratory distress syndrome (ARDS). Complication rates increase with advanced age, and 6-15% of patients over 70 years die due to COVID19. Severe COVID19 is manifesting primarily as ARDS and respiratory failure, leading to high prevalence of prolonged intensive care utilization, and thus to overwhelmed medical facilities. Currently there is no proven treatment for COVID19 severe disease. Keywords: SARS-CoV-2, COVID-19

COVID19是一种新的人畜共患病，有可能出现严重的并发症。大约20%的受影响个人发展为严重肺炎，发展为急性呼吸窘迫综合征(ARDS)。并发症的发生率随着年龄的增加而增加，70岁以上的患者中有6%-15%死于COVID19。严重的COVID19主要表现为ARDS和呼吸衰竭，导致长期使用重症监护的高流行率，从而使医疗设施不堪重负。目前还没有被证明有效的治疗COVID19严重疾病的方法。 关键词：SARS-CoV-2，新冠肺炎