Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)

摘要 项目描述：NIA的阿尔茨海默病和相关痴呆症(ADRD)里程碑8集中在 非药物干预措施的开发和翻译，鉴于以下四个事实，尤其及时。 首先，现有的药理药物显示出的效果有限。第二，老年人的数量 ADRD正在迅速增加。第三，越来越多的证据表明，非药物干预可以 增强认知和日常功能，潜在地延缓临床衰退。第四，没有里程碑的8个目标 到目前为止已经完成了。因此，拟议的认知研究方案的主要目标是 和基于神经调节的干预(RP-CNBI)旨在创建可持续和强大的基础设施 (目标1)，为下一代ADRD研究人员提供全面培训(目标2)，并制定 协商一致声明和集中分析平台(目标3)。基础设施将包括进入油井 ADRD是一个促进治疗计划和结果的神经成像平台，以老年人为特征 评价、尖端设备、远程视频保健平台、治疗和结果衡量储存库、 专职工作人员支持研究和试点资金。培训提供了说教和体验的混合- 以学习为基础，包括国际认知导向治疗专家小组的指导 (COTS)和神经调节，以及初级教职员工和博士后的工资支持和旅费 伙计们。我们将举行两次协商一致的会议，制定实践标准并确定知识差距 第2年(专注于COTS)和第5年(专注于神经调节)，直接针对里程碑8A。至 为这些会议提供经验支持，我们将完善COT中央存储库的测试版 试验被称为CogTale，并开发出一种基于神经调节的类似物，将被称为NeuroTale。 这些资料库包含相关临床试验的关键方法和结果细节，并自动 计算用于对选定数据执行自动荟萃分析的质量指数和影响大小。RP- 鉴于加州大学卓越的研究环境，CNBI为成功做好了准备 密歇根州，包括NIA P30资助的密歇根州阿尔茨海默病研究中心和VA Ann Arbor 医疗保健系统。PI作为阿尔茨海默氏症协会副主席(2021年晋升为主席)的角色 非药物干预专业兴趣领域(NPI-PIA)通过制定 为对ADRD感兴趣的各种专业人士提供协作和指导机会， 特别是那些来自服务不足的人口和发展中国家的人。尽管实际位置在 密歇根大学的RP-CNBI利用后新冠肺炎虚拟(电话/视频/互联网- 基于)创建一个协作的、可广泛访问的、不受地理环境影响的计划。这两种技术的结合 这些资源将加强方法的严谨性、培训和获得高质量所需资源的机会 非药物干预研究，共同提升里程碑8A-E。

Abstract Project description: The NIA’s Alzheimer’s disease and related dementia (ADRD) Milestone 8 focuses on the development and translation of non-pharmacologic interventions and is particularly timely given four facts. First, existing pharmacologic agents have shown limited success. Second, the number of older adults with ADRD is rapidly increasing. Third, mounting evidence indicates that non-pharmacologic interventions can enhance cognition and everyday functioning, potentially delaying clinical decline. Fourth, no Milestone 8 goals have been accomplished to date. Thus, the primary goals of the proposed Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI) are to create a sustainable and robust infrastructure (Goal 1), provide thorough training to the next generation of ADRD researchers (Goal 2), and develop consensus statements and centralized analytic platforms (Goal 3). Infrastructure will include access to well characterized older adults with ADRD, a neuroimaging platform that facilitates treatment planning and outcome evaluation, cutting-edge equipment, a tele-video-health platform, treatment and outcome measure repositories, dedicated staff to support studies, and pilot funding. Training provides a mixture of didactic and experiential- based learning, including mentorship from an international panel of experts in cognition-oriented treatments (COTs) and neuromodulation, and both salary support and travel funds for junior faculty and post-doctoral fellows. We will hold two consensus meetings that establish practice standards and identify knowledge gaps in years 2 (focused on COTs) and 5 (focused on neuromodulation), which directly address Milestone 8A. To provide empirical support for these meetings, we will refine a beta-version of a centralized repository of COT trials, known as CogTale, and develop a neuromodulation-based analogue that will be known as NeuroTale. These repositories contain key methodological and outcome details of relevant clinical trials and automatically calculate quality indices and effect sizes used to perform automated meta-analyses on selected data. The RP- CNBI is extremely well positioned for success given the outstanding research environment at the University of Michigan, including the NIA P30 funded Michigan Alzheimer’s Disease Research Center, and VA Ann Arbor Healthcare System. The PI’s role as vice-chair (ascending to chair in 2021) of the Alzheimer’s Association Non-pharmacologic Intervention Professional Interest Area (NPI-PIA) expands the Program’s reach by making collaborative and mentoring opportunities available to a wide range of professionals interested in ADRD, especially those from underserved populations and developing nations. Although physically located at the University of Michigan, the RP-CNBI leverages the post COVID-19 integration of virtual (tele-/video-/internet- based) to create a collaborative, widely-accessible program that is agnostic to geography. The combination of these resources will enhance methodologic rigor, training, and access to resources necessary for high-quality non-pharmacologic intervention research, collectively enhancing Milestones 8A-E.