Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)

基于认知和神经调节的干预研究计划（RP-CNBI）

• 批准号: 10392461
• 负责人: Benjamin Michael Hampstead
• 金额: $ 87.67万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10392461
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Clinical; Clinical Trials; Cognition; Consensus; Data; Developing Countries; Development; Elderly; Environment; Equipment; Evaluation; Faculty; Funding; Geography; Goals; Health; Healthcare Systems; Infrastructure; International; Internet; Intervention; Intervention Studies; Knowledge; Learning; Mentors; Mentorship; Meta-Analysis; Methodology; Michigan; Outcome; Outcome Measure; Pharmacology; Positioning Attribute; Postdoctoral Fellow; Program Accessibility; Research; Research Personnel; Resources; Role; Time; Training; Translations; Travel; Treatment outcome; Underserved Population; Universities; Wages; analog; base; clinically relevant; indexing; interest; meetings; neuroimaging; neuroregulation; next generation; post-COVID-19; programs; ranpirnase; repository; success; treatment planning; treatment trial; virtual

Abstract Project description: The NIA’s Alzheimer’s disease and related dementia (ADRD) Milestone 8 focuses on the development and translation of non-pharmacologic interventions and is particularly timely given four facts. First, existing pharmacologic agents have shown limited success. Second, the number of older adults with ADRD is rapidly increasing. Third, mounting evidence indicates that non-pharmacologic interventions can enhance cognition and everyday functioning, potentially delaying clinical decline. Fourth, no Milestone 8 goals have been accomplished to date. Thus, the primary goals of the proposed Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI) are to create a sustainable and robust infrastructure (Goal 1), provide thorough training to the next generation of ADRD researchers (Goal 2), and develop consensus statements and centralized analytic platforms (Goal 3). Infrastructure will include access to well characterized older adults with ADRD, a neuroimaging platform that facilitates treatment planning and outcome evaluation, cutting-edge equipment, a tele-video-health platform, treatment and outcome measure repositories, dedicated staff to support studies, and pilot funding. Training provides a mixture of didactic and experiential- based learning, including mentorship from an international panel of experts in cognition-oriented treatments (COTs) and neuromodulation, and both salary support and travel funds for junior faculty and post-doctoral fellows. We will hold two consensus meetings that establish practice standards and identify knowledge gaps in years 2 (focused on COTs) and 5 (focused on neuromodulation), which directly address Milestone 8A. To provide empirical support for these meetings, we will refine a beta-version of a centralized repository of COT trials, known as CogTale, and develop a neuromodulation-based analogue that will be known as NeuroTale. These repositories contain key methodological and outcome details of relevant clinical trials and automatically calculate quality indices and effect sizes used to perform automated meta-analyses on selected data. The RP- CNBI is extremely well positioned for success given the outstanding research environment at the University of Michigan, including the NIA P30 funded Michigan Alzheimer’s Disease Research Center, and VA Ann Arbor Healthcare System. The PI’s role as vice-chair (ascending to chair in 2021) of the Alzheimer’s Association Non-pharmacologic Intervention Professional Interest Area (NPI-PIA) expands the Program’s reach by making collaborative and mentoring opportunities available to a wide range of professionals interested in ADRD, especially those from underserved populations and developing nations. Although physically located at the University of Michigan, the RP-CNBI leverages the post COVID-19 integration of virtual (tele-/video-/internet- based) to create a collaborative, widely-accessible program that is agnostic to geography. The combination of these resources will enhance methodologic rigor, training, and access to resources necessary for high-quality non-pharmacologic intervention research, collectively enhancing Milestones 8A-E.

摘要 项目描述：NIA的阿尔茨海默病和相关痴呆症（ADRD）里程碑8侧重于 非药物干预措施的发展和转化，鉴于四个事实，这是特别及时的。 首先，现有的药物制剂显示出有限的成功。第二，老年人的数量 ADRD正在迅速增加。第三，越来越多的证据表明，非药物干预可以 增强认知和日常功能，可能延缓临床衰退。四、没有里程碑8目标 已经完成了。因此，提出的认知研究计划的主要目标 和基于神经调节的干预措施（RP-CNBI）旨在创建一个可持续和强大的基础设施 (Goal 1），为下一代ADRD研究人员提供全面培训（目标2）， 共识声明和集中的分析平台（目标3）。基础设施将包括进入水井 ADRD的特征老年人，一个促进治疗计划和结果的神经影像学平台 评估、尖端设备、远程视频保健平台、治疗和成果衡量资料库， 专门的工作人员支持研究和试点资金。培训提供了教学和体验的混合体- 基于学习，包括来自认知导向治疗的国际专家小组的指导 （COTs）和神经调节，以及初级教师和博士后的工资支持和差旅费 伙计们我们将举行两次共识会议，建立实践标准，并确定知识差距， 第2年（专注于COT）和第5年（专注于神经调节），直接解决里程碑8A。到 为这些会议提供经验支持，我们将改进COT集中存储库的测试版 试验，称为CogTale，并开发一种基于神经调节的类似物，称为NeuroTale。 这些数据库包含相关临床试验的关键方法和结果细节， 计算用于对选定数据进行自动荟萃分析的质量指数和效应量。RP- CNBI是非常好的成功定位鉴于在大学的优秀的研究环境 密歇根州，包括NIA P30资助的密歇根州阿尔茨海默病研究中心和VA安阿伯 医疗系统。PI作为阿尔茨海默氏症协会副主席（2021年升为主席）的角色 非药物干预专业兴趣区（NPI-PIA）通过使 为对ADRD感兴趣的广泛专业人士提供合作和指导机会， 特别是那些来自得不到充分服务的人口和发展中国家的人。虽然物理上位于 密歇根大学，RP-CNBI利用COVID-19后的虚拟（远程/视频/互联网）集成， 基于）创建一个协作的，广泛访问的程序，是不可知的地理。的组合 这些资源将提高方法的严谨性，培训和获得高质量的必要资源 非药物干预研究，共同增强Millipid 8A-E。