Core B: Clinical Core

摘要-核心B：临床核心 密歇根州ADRC临床核心(CC)支持和促进阿尔茨海默病及其相关研究 痴呆症(ADRD)通过招募纵向队列(LC)，其深刻的临床和生物标记物 特征描述支持中心的中心主题，即识别、理解和调节非 淀粉样蛋白导致大脑功能障碍和神经退行性变。消委会将继续利用其 强大的区域基础设施，将LC的活跃参与者从414人扩大到550人，同时 保持对有认知衰退风险或最早表现出认知衰退迹象的个体的关注。我们将加强 我们致力于通过继续运营我们在底特律的成功卫星位置(约40%)实现多样性 我们的LC确认为美国黑人)，并计划向大急流城扩张西班牙裔/拉丁裔 社区。与数据管理和统计(DMSc)、生物标记(BC)和 神经成像(NIC)核心，我们将通过共享UDS来加强可用的痴呆症相关研究资源 国家阿尔茨海默病协调中心的数据、生物标记物样本和神经成像扫描 国家阿尔茨海默病及相关痴呆症中央资料库。CC活动受到指导 以5个目标。目标1将促进和加强尖端临床研究。消委会将继续支持 广泛的药理学和非药理学临床试验以及观察研究 痴呆症谱系。NIA的持续资助将增强我们在 三所合作大学组成了密歇根州发展研究中心。目标2将增强老龄化和痴呆症的多样性 研究。我们将在我们成功的底特律卫星模型的基础上，扩展到大急流城 西班牙裔/拉丁裔社区。AIM 3将促进新型生物标记物的研究。消委会将与 DMSc、BC和NIC，以便于识别和评估低成本、非侵入性的血液 生物标志物，通过与结构和结构提供的A/T/N(和“V”-血管)分类进行比较 代谢成像。目标4将通过开发和改进反馈来增强参与者的体验。我们有 我们的LC参与者对了解他们的临床和生物标记物结果表现出极大的兴趣。我们 将与外联、招聘和参与核心合作，确保生物标记物的合乎道德的披露 并在适当的时候促进临床护理。目标5将促进培训下一代 痴呆症研究人员和临床医生。与研究教育部门合作，协调委员会将 利用全面的资源和多样化的培训机会，为职业生涯早期提供 调查人员在三所参与大学的校园里进行了调查。总而言之，CC将把关键 支持多学科研究的机构和区域资源，从早期发现到 治疗性干预。我们对少数族裔招募、新的生物标志物和参与者反馈的重视将 在密歇根州ADRC和更广泛的ADC网络内支持新的研究途径。

ABSTRACT – CORE B: CLINICAL CORE The Michigan ADRC Clinical Core (CC) supports and advances research on Alzheimer’s disease and related dementias (ADRD) through recruitment of a longitudinal cohort (LC), whose deep clinical and biomarker characterization supports the center’s central theme of identifying, understanding, and modulating the non- amyloid factors contributing to brain dysfunction and neurodegeneration. The CC will continue to draw on its robust regional infrastructure to expand the LC from 414 active participants to 550 participants, while maintaining a focus on individuals at risk for or showing the earliest signs of cognitive decline. We will intensify our commitment to diversity through continued operation of our successful satellite location in Detroit (~40% of our LC identifies as Black American) and a planned expansion to the Grand Rapids Hispanic/Latino community. In conjunction with the Data Management and Statistical (DMSC), Biomarker (BC), and Neuroimaging (NIC) Cores, we will strengthen available dementia-related research resources by sharing UDS data, biomarker specimens, and neuroimaging scans with the National Alzheimer’s Coordinating Center and the National Centralized Repository for Alzheimer’s Disease and Related Dementias. CC activities are guided by 5 aims. Aim 1 will facilitate and enhance cutting-edge clinical research. The CC will continue to support a wide range of pharmacologic and non-pharmacologic clinical trials as well as observational studies that span the dementia spectrum. Continued NIA funding will enhance our capacity to advance ADRD research at the three partner universities comprising the Michigan ADRC. Aim 2 will enhance diversity in aging and dementia research. We will build on our successful Detroit satellite model and expand into the Grand Rapids Hispanic/Latino community. Aim 3 will promote novel biomarker research. The CC will collaborate with the DMSC, BC and NIC to facilitate the identification and evaluation of low-cost, non-invasive blood-based biomarkers, through comparison to the A/T/N (and “V” – vascular) classification provided by structural and metabolic imaging. Aim 4 will enhance participant experience by developing and refining feedback. We have identified overwhelming interest among our LC participants in learning their clinical and biomarker results. We will partner with the Outreach, Recruitment, and Engagement Core to ensure ethical disclosure of biomarker findings and facilitate clinical care as appropriate. Aim 5 will facilitate the training of the next generation of dementia researchers and clinicians. Collaborating with the Research Education Component, the CC will leverage the comprehensive resources and diverse training opportunities available for early career investigators across the campuses of the three participating universities. In summary, the CC will link critical institutional and regional resources to support multi-disciplinary research, spanning from early detection to therapeutic intervention. Our emphasis on minority recruitment, novel biomarkers, and participant feedback will bolster new avenues of research within the Michigan ADRC and the broader ADC network.