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Three-Dimensional UTE Magnetic Resonance Imaging of the Osteochondral Junction

骨软骨连接处的三维 UTE 磁共振成像

基本信息

批准号：
10207470
负责人：
Yajun Ma
金额：
$ 16.81万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10207470
关键词：
3-Dimensional Affect Age American Blood Vessels Bone Marrow Bone plates Cadaver Cartilage Clinical Clinical Treatment Cone Degenerative polyarthritis Diagnosis Disease Evaluation Extracellular Matrix Degradation Fatty acid glycerol esters Goals Histology Human Image Inflammation Joints Knee joint Ligaments Magnetic Resonance Imaging Marrow Metalloproteases Monitor Morphology Nerve Osteoclasts Pathogenesis Pathologic Patients Performance Physiologic pulse Play Preparation Protons Public Health Radial Recovery Reference Standards Relaxation Replacement Arthroplasty Reporting Resolution Role Sampling Scanning Scheme Series Signal Transduction Societies Source Specimen Stress System Techniques Tendon structure Time Tissues Up-Regulation Weight Weight-Bearing state Work arthropathies articular cartilage bone calcification clinical Diagnosis contrast imaging cost density healthy volunteer improved in vivo in vivo imaging interest knee replacement arthroplasty osteochondral tissue quantitative imaging radio frequency sex subchondral bone substantia spongiosa

项目摘要

Abstract Osteoarthritis (OA) is one of the most prevalent diseases in the US, affecting over 50 million Americans with an annual cost of more than $60 billion per year. The major public health issues associated with OA are likely to become even more important as our society ages. OA is considered a whole joint disease with pathologic changes that often involve all of the constituent joint tissues. Of increasing interest is the region of the osteochondral junction (OCJ), which encompasses the tissues between the deep uncalcified layers of cartilage and the marrow spaces of the trabecular bone. It includes the deep radial uncalcified cartilage, tidemark, calcified cartilage (CC), and subchondral bone (SCB) plate. While these tissues are avascular in the normal joint, in OA, osteoclasts are activated and form channels through the subchondral bone plate, allowing blood vessels and nerves to extend from the marrow into deep cartilage. This is associated with a cascade of abnormalities, including local inflammation and upregulation of metalloproteinase activity, extracellular matrix degradation, reduction of cartilage load-bearing capacity, and degenerative change. The OCJ may change dramatically in OA, and these changes may be relevant in its pathogenesis. Magnetic resonance imaging (MRI) is widely used to directly and non-invasively evaluate articular cartilage and plays an important role in the clinical diagnosis and treatment of OA. However, MRI of the OCJ region is difficult due to the short mean transverse relaxation times (i.e., short T2 or T2*) of deep radial uncalcified articular cartilage, calcified cartilage, and subchondral bone, which result in little or no signal when conventional pulse sequences are used. In this study we aim to develop 3D adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-Cones) techniques for direct volumetric morphological imaging and quantitative mapping of the OCJ, to validate the signal sources, and finally develop translational 3D IR-Cones techniques for OCJ imaging in vivo. In Aim 1 we will further develop and validate 3D IR-Cones techniques for morphological and quantitative imaging of the OCJ in osteochondral samples from cadaveric human knee joints (n=10). We will investigate the effect of spatial resolution, long T2 suppression, RF power, and gradient strengths, as well as T1, T2*, and proton density weightings in OCJ imaging on a 3T Bruker small-bore scanner and a clinical 3T scanner, respectively. We will correlate morphological and quantitative Cones findings with µCT and histology. In Aim 2 we will develop translational 3D IR-Cones techniques for morphological and quantitative imaging of the OCJ in knee joints of healthy volunteers (n=10) and patients subject to total knee replacement (n=10). The excised osteochondral samples from relatively normal (n=10) and more degenerated regions (n=10) will be re-scanned with clinical and 3D IR-Cones sequences, followed by µCT imaging and histology. In vivo and ex vivo 3D IR- Cones imaging of the OCJ will be compared and correlated with µCT imaging and histology.

摘要

项目成果

期刊论文数量（32）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The effect of cartilage dehydration and rehydration on quantitative ultrashort echo time biomarkers.

DOI：
10.21037/qims-23-359
发表时间：
2023-10-01
期刊：
Quantitative imaging in medicine and surgery
影响因子：
2.8
作者：
通讯作者：

Assessment of mechanical properties of articular cartilage with quantitative three-dimensional ultrashort echo time (UTE) cones magnetic resonance imaging.

DOI：
10.1016/j.jbiomech.2020.110085
发表时间：
2020-12-02
期刊：
Journal of biomechanics
影响因子：
2.4
作者：
Namiranian B;Jerban S;Ma Y;Dorthe EW;Masoud-Afsahi A;Wong J;Wei Z;Chen Y;D'Lima D;Chang EY;Du J
通讯作者：
Du J

AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.

AcidoCEST-UTE MRI 显示膝骨关节炎的酸性微环境。

DOI：
10.3390/ijms23084466
发表时间：
2022-04-18
期刊：
International journal of molecular sciences
影响因子：
5.6
作者：
通讯作者：

High contrast cartilaginous endplate imaging using a 3D adiabatic inversion-recovery-prepared fat-saturated ultrashort echo time (3D IR-FS-UTE) sequence.

DOI：
10.1002/nbm.4579
发表时间：
2021-10
期刊：
NMR in biomedicine
影响因子：
2.9
作者：
Lombardi AF;Wei Z;Wong J;Carl M;Lee RR;Wallace M;Masuda K;Chang EY;Du J;Ma YJ
通讯作者：
Ma YJ

Evaluation of enzymatic proteoglycan loss and collagen degradation in human articular cartilage using ultrashort echo time-based biomarkers: A feasibility study.