Three-Dimensional UTE Magnetic Resonance Imaging of the Osteochondral Junction

骨软骨连接处的三维 UTE 磁共振成像

基本信息

  • 批准号:
    10207470
  • 负责人:
  • 金额:
    $ 16.81万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-01 至 2023-06-30
  • 项目状态:
    已结题

项目摘要

Abstract Osteoarthritis (OA) is one of the most prevalent diseases in the US, affecting over 50 million Americans with an annual cost of more than $60 billion per year. The major public health issues associated with OA are likely to become even more important as our society ages. OA is considered a whole joint disease with pathologic changes that often involve all of the constituent joint tissues. Of increasing interest is the region of the osteochondral junction (OCJ), which encompasses the tissues between the deep uncalcified layers of cartilage and the marrow spaces of the trabecular bone. It includes the deep radial uncalcified cartilage, tidemark, calcified cartilage (CC), and subchondral bone (SCB) plate. While these tissues are avascular in the normal joint, in OA, osteoclasts are activated and form channels through the subchondral bone plate, allowing blood vessels and nerves to extend from the marrow into deep cartilage. This is associated with a cascade of abnormalities, including local inflammation and upregulation of metalloproteinase activity, extracellular matrix degradation, reduction of cartilage load-bearing capacity, and degenerative change. The OCJ may change dramatically in OA, and these changes may be relevant in its pathogenesis. Magnetic resonance imaging (MRI) is widely used to directly and non-invasively evaluate articular cartilage and plays an important role in the clinical diagnosis and treatment of OA. However, MRI of the OCJ region is difficult due to the short mean transverse relaxation times (i.e., short T2 or T2*) of deep radial uncalcified articular cartilage, calcified cartilage, and subchondral bone, which result in little or no signal when conventional pulse sequences are used. In this study we aim to develop 3D adiabatic inversion recovery prepared ultrashort echo time Cones (3D IR-Cones) techniques for direct volumetric morphological imaging and quantitative mapping of the OCJ, to validate the signal sources, and finally develop translational 3D IR-Cones techniques for OCJ imaging in vivo. In Aim 1 we will further develop and validate 3D IR-Cones techniques for morphological and quantitative imaging of the OCJ in osteochondral samples from cadaveric human knee joints (n=10). We will investigate the effect of spatial resolution, long T2 suppression, RF power, and gradient strengths, as well as T1, T2*, and proton density weightings in OCJ imaging on a 3T Bruker small-bore scanner and a clinical 3T scanner, respectively. We will correlate morphological and quantitative Cones findings with µCT and histology. In Aim 2 we will develop translational 3D IR-Cones techniques for morphological and quantitative imaging of the OCJ in knee joints of healthy volunteers (n=10) and patients subject to total knee replacement (n=10). The excised osteochondral samples from relatively normal (n=10) and more degenerated regions (n=10) will be re-scanned with clinical and 3D IR-Cones sequences, followed by µCT imaging and histology. In vivo and ex vivo 3D IR- Cones imaging of the OCJ will be compared and correlated with µCT imaging and histology.
摘要 骨关节炎(OA)是美国最常见的疾病之一,影响超过5000万美国人 每年的成本超过600亿美元。与OA相关的主要公共卫生问题是 随着我们社会的老龄化,它可能会变得更加重要。OA被认为是一种整体关节疾病, 病理变化,往往涉及所有的组成关节组织。越来越令人感兴趣的是 骨软骨交界处(OCJ),它包括深未钙化层之间的组织, 软骨和骨小梁的骨髓间隙。它包括深层桡骨未钙化软骨, 潮标、钙化软骨(CC)和软骨下骨(SCB)板。虽然这些组织在血管中是无血管的, 在正常关节中,在OA中,破骨细胞被激活并形成穿过软骨下骨板的通道, 血管和神经从骨髓延伸到深层软骨。这与一系列的 异常,包括局部炎症和金属蛋白酶活性上调,细胞外基质 降解、软骨承重能力降低和退行性变化。OCJ可能会改变 这些变化可能与其发病机制有关。磁共振成像 (MRI)广泛用于直接和非侵入性地评价关节软骨, OA的临床诊断和治疗。然而,由于短的平均值,OCJ区域的MRI是困难的 横向弛豫时间(即,短T2或T2*)的深桡骨未钙化关节软骨,钙化软骨, 和软骨下骨,当使用常规脉冲序列时,这导致很少或没有信号。 在这项研究中,我们的目标是发展三维绝热反演恢复制备超短回波时间锥(三维 IR-Cones)技术进行直接体积形态学成像和OCJ的定量映射, 验证信号源,并最终开发用于OCJ体内成像的平移3D IR-Cones技术。 在目标1中,我们将进一步开发和验证用于形态学和定量分析的3D IR锥技术。 来自尸体人膝关节的骨软骨样品中的OCJ成像(n=10)。我们将调查 空间分辨率、长T2抑制、RF功率和梯度强度以及T1、T2* 和 在3 T Bruker小口径扫描仪和临床3 T扫描仪上的OCJ成像中的质子密度加权, 分别我们将把形态学和定量锥细胞发现与µCT和组织学相关联。在目标2中 我们将开发用于OCJ形态学和定量成像的平移3D IR锥技术, 健康志愿者(n=10)和全膝关节置换术患者(n=10)的膝关节。切除的 将重新扫描相对正常(n=10)和更严重退化区域(n=10)的骨软骨样本 临床和3D IR-Cones序列,随后进行µCT成像和组织学检查。体内和离体3D IR- OCJ的锥体成像将与µCT成像和组织学进行比较和关联。

项目成果

期刊论文数量(32)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The effect of cartilage dehydration and rehydration on quantitative ultrashort echo time biomarkers.
Assessment of mechanical properties of articular cartilage with quantitative three-dimensional ultrashort echo time (UTE) cones magnetic resonance imaging.
  • DOI:
    10.1016/j.jbiomech.2020.110085
  • 发表时间:
    2020-12-02
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Namiranian B;Jerban S;Ma Y;Dorthe EW;Masoud-Afsahi A;Wong J;Wei Z;Chen Y;D'Lima D;Chang EY;Du J
  • 通讯作者:
    Du J
AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.
AcidoCEST-UTE MRI 显示膝骨关节炎的酸性微环境。
High contrast cartilaginous endplate imaging using a 3D adiabatic inversion-recovery-prepared fat-saturated ultrashort echo time (3D IR-FS-UTE) sequence.
  • DOI:
    10.1002/nbm.4579
  • 发表时间:
    2021-10
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Lombardi AF;Wei Z;Wong J;Carl M;Lee RR;Wallace M;Masuda K;Chang EY;Du J;Ma YJ
  • 通讯作者:
    Ma YJ
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Yajun Ma其他文献

Yajun Ma的其他文献

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{{ truncateString('Yajun Ma', 18)}}的其他基金

Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.
腰椎间盘超短回波时间磁共振成像。
  • 批准号:
    10446888
  • 财政年份:
    2022
  • 资助金额:
    $ 16.81万
  • 项目类别:
Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.
腰椎间盘超短回波时间磁共振成像。
  • 批准号:
    10600038
  • 财政年份:
    2022
  • 资助金额:
    $ 16.81万
  • 项目类别:
Three-Dimensional UTE Magnetic Resonance Imaging of the Osteochondral Junction
骨软骨连接处的三维 UTE 磁共振成像
  • 批准号:
    10058140
  • 财政年份:
    2020
  • 资助金额:
    $ 16.81万
  • 项目类别:

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