Administrative Core

行政核心

• 批准号: 10207345
• 负责人: Arlene H. Sharpe
• 金额: $ 37.75万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-05 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207345
• 关键词: Administrative Personnel; Animals; Applications Grants; Award; Bioinformatics; CRISPR screen; CRISPR/Cas technology; Caliber; Cells; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communication; Communities; Conflict (Psychology); Conflict of Interest; Data; Data Analyses; Ensure; Funding; Genetic Screening; Goals; Grant; Group Meetings; Guidelines; Hospitals; Human; Human Resources; Human Subject Research; Immunity; Individual; Infrastructure; Institutes; Institution; Lead; Leadership; Manuscripts; Mediating; Methods; Monitor; Online Systems; Pilot Projects; Preparation; Principal Investigator; Procedures; Process; Progress Reports; PubMed; Public Policy; Reporting; Research Personnel; Research Project Grants; Research Support; Resolution; Resource Sharing; Schedule; Scientist; Secure; Services; Structure; System; Teleconferences; Time; Travel; United States National Institutes of Health; Validation; acute infection; adaptive immune response; base; career; conflict resolution; data management; data portal; data sharing; in vivo; innovation; innovative technologies; medical schools; meetings; member; mouse model; novel; operation; organizational structure; programs; screening; success; web portal

The major objectives of the Administrative Core are to institute an infrastructure that facilitates productive interactions among the U19 Program investigators of this grant application, “Defining regulators of immunity to acute infection using CRISPR screens” and implements our Pilot Project program. The Administrative Core will serve as a centralized, transparent organizational structure to provide administrative support that enables the Principal investigators and their personnel to focus on their experimental and scientific goals. Dr. Sharpe, Program Director of the overall U19 grant, will provide leadership and direction for operations of the Administrative Core, which will be based at Harvard Medical School. Dr. Haining, Co-Director of this U19 grant and Core A, will lead the Pilot Grant Program. The Administrative Core will be responsible for carrying out the following functions: a) Provide the infrastructure for overall management and co-ordination; b) Facilitate and promote interactions and communication between program investigators, scientific advisors and administrative personnel; c) Plan and coordinate annual External Scientific Advisory Group (ESAG) meetings; d) Organize and coordinate travel for ESAG members; e) Assist the Program Directors and Principal Investigators with oversight of scientific, fiscal, regulatory and compliance matters, and with preparation and review of yearly progress reports and financial reports; f) Implement a plan for data management/sharing among investigators; and g) Implement the Pilot Project Program. The Administrative Core will also resolve all conflicts that may arise. To achieve these goals, Core A has the following specific aims: Aim 1: To provide infrastructure for overall management and coordination. Core A will provide administrative support and coordination to promote communication and interactions among Project and Core investigators, including the scheduling of regular teleconferences/face-to-face meetings and annual meetings, preparing and submitting annual progress reports, providing fiscal oversight and ensuring institutional compliance with fiscal, regulatory and scientific issues, and conflict resolution. Aim 2: To maintain a web-based portal for data sharing via a secure Dropbox. Core A will host and manage a secure Dropbox portal for data sharing within the U19. This easy access to data will maximize transparency, encourage collaboration, and aid in monitoring project progress and how collaborators are utilizing core services. Aim 3: To implement the Pilot Project Program. Core A will develop an effective process to solicit review and award high caliber innovative Pilot Projects that use our in vivo CRISPR platform, and monitor their progress. We will encourage applications from early career investigators. Through these specific Aims, we will create an Administrative Core structured to implement processes/procedures to enable the success of this highly collaborative program.

行政核心的主要目标是建立一个基础设施， U19计划研究人员之间富有成效的互动，“定义 使用CRISPR筛选急性感染免疫力的调节因子”，并实施我们的试点项目 程序.行政核心将作为一个集中、透明的组织结构， 提供行政支持，使主要研究人员及其工作人员能够专注于 他们的实验和科学目标。夏普博士，整个U19赠款的项目主任，将 为行政核心的运作提供领导和指导，行政核心将设在 哈佛医学院。海宁博士，U19资助和核心A的联合主任，将领导试点资助 程序.行政核心将负责履行以下职能： 全面管理和协调的基础设施; B）促进和促进互动， 项目研究人员、科学顾问和行政人员之间的沟通; c）计划 并协调外部科学咨询小组（ESAG）年度会议; d）组织和 协调ESAG成员的旅行; e）协助项目主任和主要研究者 监督科学、财政、监管和遵约事项，并编制和审查 年度进度报告和财务报告; f）执行数据管理/共享计划， （四）实施试点项目。行政核心还将解决所有 可能出现的冲突。为了实现这些目标，核心A有以下具体目标：目标1： 为全面管理和协调提供基础设施。核心A将提供行政 支持和协调，以促进项目和核心之间的沟通和互动 包括定期电话会议/面对面会议和年度会议的时间安排 会议，编写和提交年度进展报告，提供财政监督，并确保 在财政、监管和科学问题上的体制合规以及冲突解决。目标2： 维护一个基于Web的门户网站，通过安全的Dropbox共享数据。核心A将托管和管理 一个安全的Dropbox门户，用于在U19内共享数据。这种对数据的轻松访问将最大限度地提高 透明度，鼓励合作，并协助监测项目进度以及合作者如何 使用核心服务。目标3：实施试点项目方案。核心A将开发一个 有效的流程，以征求审查和奖励高素质的创新试点项目，使用我们的体内 CRISPR平台，并监测其进展。我们将鼓励从职业生涯的早期申请 investigators.通过这些具体的目标，我们将建立一个行政核心， 实施流程/程序，以使这一高度协作的计划取得成功。