Mapping the Evidence for the WHO Classification of Tumours: a Living Evidence Gap Map by Tumour Type

绘制世界卫生组织肿瘤分类的证据：按肿瘤类型划分的活体证据差距图

• 批准号: 10040375
• 金额: $ 57.56万
• 依托单位: UNIVERSITY OF OXFORD
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10040375
• 关键词: Mapping; Evidence; WHO; Classification; Tumours

The WHO Classification of Tumours (WCT) underpins cancer diagnosis, and hence treatment and care of cancer patients, as well as research into cancer epidemiology, prevention, diagnosis, and treatment. However, decisions for such a global reference tool are not always informed by the best available evidence, and risks of incorporating misinformation into the clinical decisions pathway exist. We aim to develop a tool that maps existing evidence, showing gaps, identifying pockets of low-level evidence, and synthesis of reliable evidence. The tool will map the evidence base of the WCT in order to facilitate evidence-based decision-making in pathology, and promote the application of higher research standards in the field. We will adapt the recently developed Evidence Gap Map (EGM) methodology, first time ever to be used in biomedicine. The resulting EGMs will increase the discoverability and use of studies by the WCT decision-makers, research commissioners, researchers and others. Our WCT-EVI-MAP project is organized in three subsequent phases, where we will apply a stepwise approach to: first, develop a framework and define evidence levels based on expert consensus; second, elaborate a series of Megamaps in iterative cycles describing evidence of all tumour types; third, perform a descriptive analysis of the use of evidence in a continuous updated exercise. To overcome identified challenges, several strategies are proposed, such as using recent advances in technologies, following a strict multidisciplinary approach and integrating this project into the WCT strategic planning for the 6th edition. We believe that the WCT EVI-MAP will represent a ground-breaking advance for the WCT and research in the field, and will accelerate progress in cancer diagnosis and management. Integration of evidence-based medicine methods has been shown to have a positive impact in other specialized medical fields and our project represents a first step towards an evidence-based pathology.

世界卫生组织肿瘤分类 (WCT) 是癌症诊断、癌症患者治疗和护理以及癌症流行病学、预防、诊断和治疗研究的基础。然而，这种全球参考工具的决策并不总是以最佳可用证据为依据，并且存在将错误信息纳入临床决策路径的风险。我们的目标是开发一种工具来绘制现有证据、显示差距、识别低水平证据以及综合可靠证据。该工具将绘制WCT的证据基础，以促进病理学领域的循证决策，并促进更高研究标准在该领域的应用。我们将采用最近开发的证据差距图（EGM）方法，这是首次用于生物医学。由此产生的 EGM 将提高 WCT 决策者、研究专员、研究人员和其他人对研究的发现和使用。我们的 WCT-EVI-MAP 项目分为三个后续阶段，我们将采用逐步方法：首先，根据专家共识制定框架并定义证据级别；其次，在迭代周期中详细阐述一系列巨型地图，描述所有肿瘤类型的证据；第三，在不断更新的练习中对证据的使用进行描述性分析。为了克服已确定的挑战，提出了多种策略，例如利用最新的技术进步、遵循严格的多学科方法以及将该项目纳入第六版 WCT 战略规划中。我们相信，WCT EVI-MAP 将代表 WCT 和该领域研究的突破性进展，并将加速癌症诊断和管理的进展。循证医学方法的整合已被证明对其他专业医学领域产生积极影响，我们的项目代表了迈向循证病理学的第一步。