Training in Basic and Translational Digestive Sciences

基础和转化消化科学培训

• 批准号: 10207610
• 负责人: CHUNG OWYANG
• 金额: $ 27.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207610
• 关键词: Science; Training

The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades. Since its inception in 1989, our original NIDDK-funded training program supported a large number of physician scientists and clinical investigators, many of whom now maintain full time academic positions in the U.S. The original grant, which was designed mainly to train physician scientists, was until 2009 continuously funded for 20 years. In 2012 we started a new training program that focuses solely on training postdoctoral (MD, PhD, MD/PhD) and predoctoral PhD candidate scientists interested in basic and translational digestive sciences. In addition to eight gastroenterologist physician scientists (all R01 holders), we have expanded our research base to include an additional 17 R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (7), Department of Pathology (3), Department of Cell and Developmental Biology (2), Department of Microbiology and Immunology (2), Division of Infectious Diseases (1), Division of Metabolism, Endocrinology, & Diabetes (1), and Division of Hematology/Oncology (1). This program consolidates the major investigators who are conducting gastrointestinal research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in basic and translational digestive sciences. Our group of 25 program faculty are all members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986, and bring a long history of collaboration and team science. The training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) neurobiology of obesity and appetite control, visceral pain and neurosignaling regulating GI motility; 2) molecular and cellular mechanisms of inflammation, tissue injury and repair; 3) cell growth, differentiation, neoplastic development and programmed cell death. Continued support is requested for 3 predoctoral trainees seeking PhDs in one of eight disciplines that range from Physiology to Cell and Molecular Biology, and for 3 postdoctoral trainees. The program will be co-directed by Chung Owyang, MD (Chief of the Division of Gastroenterology) and Bishr Omary, MD, PhD (Chair of Physiology), and includes coursework, seminars, strong mentoring and other enriching features. The efforts of the trainees will be supported by 25,000 ft2 of research space and more than $20 million of annual NIH research funding. The combined mass and diversity of available resources and the demonstrated successes of the training faculty past and current mentees provide strong evidence that this program will be highly successful in training the next generation of investigators interested in basic and translational digestive sciences.

在过去的几年里，密歇根大学在胃肠科学方面的培训有着卓越的历史 几十年。自1989年成立以来，我们最初由NIDDK资助的培训计划支持了大量 内科科学家和临床研究人员，他们中的许多人现在在 美国最初的拨款主要用于培训内科科学家，一直持续到2009年 资助了20年。2012年，我们启动了一项新的培训计划，仅专注于博士后培训 (医学博士、博士、医学博士/博士)和对基础消化和翻译消化感兴趣的博士前博士生 科学。除了八名胃肠病内科科学家(都是R01持有者)外，我们还扩大了我们的 研究基地将包括另外17名由R01资助的基础和内科科学家 分子与综合生理学(7)，病理学系(3)，细胞与发育系 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--文摘内容 代谢、内分泌学、糖尿病(1)和血液/肿瘤科(1)。本节目 整合了在密歇根大学进行胃肠研究的主要研究人员 把医学院打造成培养内科科学家和生物医学的强大导师核心 对基础和翻译消化科学感兴趣的研究人员。我们的25名项目教职员工都是 自1986年以来，由NIH(P30 DK34933)资助的密歇根消化疾病核心中心的成员，以及 带来源远流长的协作和团队科学。培训方案侧重于三个主题领域 在参与的教职员工之间提供卓越的跨学科合作：1) 肥胖和食欲控制，内脏疼痛和神经信号调节胃肠动力；2)分子和细胞 炎症、组织损伤和修复的机制；3)细胞生长、分化、肿瘤发展 以及程序性细胞死亡。要求继续为3名博士前实习生提供支持，他们正在攻读下列学科之一的博士学位 8个学科，从生理学到细胞和分子生物学，以及3名博士后实习生。这个 该项目将由Chung OwYang医学博士(消化内科主任)和Bishr共同指导 医学博士，博士(生理学主席)，包括课程、研讨会、强有力的指导和其他 丰富功能。受训者的努力将得到25,000平方英尺的研究空间和超过 美国国立卫生研究院每年2000万美元的研究经费。可用资源的数量和多样性以及 过去和现在培训教师的成功证明有力地证明了这一点。 该计划将非常成功地培养对基础和 翻译消化科学。