Training in Basic and Translational Digestive Sciences

基础和转化消化科学培训

• 批准号: 10207610
• 负责人: CHUNG OWYANG
• 金额: $ 27.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207610
• 关键词: Science; Training

The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades. Since its inception in 1989, our original NIDDK-funded training program supported a large number of physician scientists and clinical investigators, many of whom now maintain full time academic positions in the U.S. The original grant, which was designed mainly to train physician scientists, was until 2009 continuously funded for 20 years. In 2012 we started a new training program that focuses solely on training postdoctoral (MD, PhD, MD/PhD) and predoctoral PhD candidate scientists interested in basic and translational digestive sciences. In addition to eight gastroenterologist physician scientists (all R01 holders), we have expanded our research base to include an additional 17 R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (7), Department of Pathology (3), Department of Cell and Developmental Biology (2), Department of Microbiology and Immunology (2), Division of Infectious Diseases (1), Division of Metabolism, Endocrinology, & Diabetes (1), and Division of Hematology/Oncology (1). This program consolidates the major investigators who are conducting gastrointestinal research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in basic and translational digestive sciences. Our group of 25 program faculty are all members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986, and bring a long history of collaboration and team science. The training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) neurobiology of obesity and appetite control, visceral pain and neurosignaling regulating GI motility; 2) molecular and cellular mechanisms of inflammation, tissue injury and repair; 3) cell growth, differentiation, neoplastic development and programmed cell death. Continued support is requested for 3 predoctoral trainees seeking PhDs in one of eight disciplines that range from Physiology to Cell and Molecular Biology, and for 3 postdoctoral trainees. The program will be co-directed by Chung Owyang, MD (Chief of the Division of Gastroenterology) and Bishr Omary, MD, PhD (Chair of Physiology), and includes coursework, seminars, strong mentoring and other enriching features. The efforts of the trainees will be supported by 25,000 ft2 of research space and more than $20 million of annual NIH research funding. The combined mass and diversity of available resources and the demonstrated successes of the training faculty past and current mentees provide strong evidence that this program will be highly successful in training the next generation of investigators interested in basic and translational digestive sciences.

密歇根大学在过去的几年里在胃肠道科学方面有着极好的培训历史。 几十年自1989年成立以来，我们最初的NIDDK资助的培训计划支持了大量的 医生科学家和临床研究人员，其中许多人现在保持全职学术职位， 美国最初的赠款主要用于培训医生科学家，一直持续到2009年。 资助了20年。在2012年，我们开始了一个新的培训计划，专注于培养博士后 (MD，博士，医学博士/博士）和博士前博士候选人的科学家感兴趣的基础和翻译消化 以理工科为重除了八名胃肠病学家医生科学家（所有R 01持有者）外，我们还扩大了我们的 研究基地，包括一个额外的17个R 01资助的基础和医生的科学家从部门 分子与综合生理学（7），病理学系（3），细胞与发育学系 生物学（2），微生物学和免疫学系（2），传染病科（1）， 代谢、内分泌学和糖尿病（1），血液学/肿瘤学分部（1）。这个程序 巩固了在密歇根大学进行胃肠道研究的主要研究人员 医学院成为一个强大的导师核心，用于培养医生科学家和生物医学 对基础和转化消化科学感兴趣的研究人员。我们的25名项目教师都是 自1986年以来由NIH资助的密歇根消化疾病核心中心（P30 DK 34933）的成员，以及 带来了合作和团队科学的悠久历史。培训计划侧重于三个主题领域 提供参与教师之间的特殊跨学科合作：1）神经生物学 肥胖和食欲控制，内脏疼痛和神经信号调节GI运动; 2）分子和细胞 炎症、组织损伤和修复机制; 3）细胞生长、分化、肿瘤发展 和程序性细胞死亡要求继续支持3名博士前学员在其中一个寻求博士学位， 8个学科，从生理学到细胞和分子生物学，3名博士后。的 该项目将由Chung Owyang医学博士（胃肠病学科主任）和Bishr共同指导 奥玛丽，医学博士，博士（生理学主席），包括课程，研讨会，强大的指导和其他 丰富功能。学员的努力将得到25，000平方英尺的研究空间和超过1000平方英尺的研究空间的支持。 每年2000万美元的NIH研究经费。现有资源的总量和多样性以及 培训教师过去和现在的学员所取得的成功有力地证明了这一点， 该计划将非常成功地培训下一代的调查人员感兴趣的基本和 转化消化科学