Training in Basic and Translational Digestive Sciences

描述（由申请人提供）：在过去的几十年里，密歇根大学在胃肠科学方面有着卓越的培训历史。自1989年成立以来，我们最初的niddk资助的培训计划支持了大量的内科科学家，其中许多人现在在美国保持全职学术职位。最初的拨款主要是为了培训内科科学家，直到最近才连续资助了20年。我们现在已经开发了一个新的项目，专注于培养对基础和转化消化科学感兴趣的博士后（医学博士，博士，医学博士/博士）和博士前博士候选人。除了7位星相学家内科科学家（Owyang, Merchant, Wiley, Kao, Todisco, Zimmermann, Wang，所有R01获得者），我们还扩大了我们的研究基地，包括来自分子和综合生理学系（Omary, Rui, Samuelson, Shah, Williams），病理学系（Nunez），细胞和发育生物学学系（Gumucio）的另外9位R01资助的基础和内科科学家。传染病部（Young）和代谢、内分泌和糖尿病部（Myers）。该项目将密歇根大学医学院进行胃肠研究的主要研究人员整合为一个强大的核心导师，为对基础和转化感兴趣的内科科学家和生物医学研究人员提供培训

DESCRIPTION (provided by applicant): The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades. Since its inception in 1989, our original NIDDK-funded training program supported a large number of physician scientists, many of whom now maintain full time academic positions in the U.S. The original grant, which was designed mainly to train physician scientists was until recently continuously funded for 20 years. We now have developed a new program that focuses solely on training postdoctoral (MD, PhD, MD/PhD) and predoctoral PhD candidate scientists interested in basic and translational digestive sciences. In addition to seven astroenterologist physician scientists (Owyang, Merchant, Wiley, Kao, Todisco, Zimmermann, Wang, all R01 holders), we have expanded our research base to include an additional nine R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (Omary, Rui, Samuelson, Shah, Williams), Department of Pathology (Nunez), Department of Cell and Developmental Biology (Gumucio), Division of Infectious Diseases (Young) and Division of Metabolism, Endocrinology, & Diabetes (Myers). This program consolidates the major investigators who are conducting gastrointestinal research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in basic and translational digestive sciences. Our group of 16 program faculty are all members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986, and bring a long history of collaboration and team science. The training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) neurobiology of peptide control, visceral pain and neurosignaling regulating GI motility; 2) molecular and cellular mechanisms of inflammation, tissue injury and repair; 3) cell growth, differentiation and programmed cell death. Support is requested for 4 predoctoral trainees seeking PhDs in one of eight disciplines that range from Physiology to Cell and Molecular Biology and for 4 postdoctoral trainees. The program will be co-directed by Chung Owyang , MD (Chief of the Division of Gastroenterology) and Bishr Omary, MD, PhD (Chair of Physiology) and includes unique coursework, seminars, strong mentoring and other enriching features. The efforts of the trainees will be supported by 20,000 ft2 of research space and more than $20 million of annual NIH research funding. The combined mass and diversity of available resources and the demonstrated successes of the faculty's prior trainees provide tangible evidence that this program will be successful in training the next generation of investigators interested in basi and translational digestive sciences.