Training in Basic and Translational Digestive Sciences

描述（由申请人提供）：密歇根大学在过去的几十年里在胃肠道科学方面有着悠久的历史。自1989年成立以来，我们最初的NIDDK资助的培训计划支持了大量的医生科学家，其中许多人现在在美国保持全职学术职位。我们现在已经开发了一个新的计划，专注于培养对基础和转化消化科学感兴趣的博士后（MD，PhD，MD/PhD）和博士前博士候选科学家。除了七位占星学家外，（Owyang，Merchant，Wiley，Kao，Todisco，Zimmermann，Wang，所有R 01持有者），我们扩大了我们的研究基地，包括来自分子和综合生理学系的另外9名R 01资助的基础和医生科学家（Omary，Rui，Samuelson，Shah，威廉姆斯），病理学系（Nunez），细胞和发育生物学系（Gumucio），传染病系（Young）和代谢系，内分泌学和糖尿病（Myers）。该计划巩固了在密歇根大学医学院进行胃肠道研究的主要研究人员，成为一个强大的导师核心，用于培训对基础和翻译感兴趣的医生科学家和生物医学研究人员。 消化科学我们的16名项目教师都是自1986年以来由NIH（P30 DK 34933）资助的密歇根消化系统疾病核心中心的成员，并带来了合作和团队科学的悠久历史。培训计划侧重于三个主题领域，为参与教师提供卓越的跨学科合作：1）肽控制，内脏疼痛和神经信号调节GI运动的神经生物学; 2）炎症，组织损伤和修复的分子和细胞机制; 3）细胞生长，分化和程序性细胞死亡。要求支持4名博士前实习生在从生理学到细胞和分子生物学的8个学科之一寻求博士学位，并支持4名博士后实习生。该计划将由Chung Owyang，MD（胃肠病学系主任）和Bishr Omary，MD，PhD（生理学系主任）共同指导，包括独特的课程，研讨会，强有力的指导和其他丰富的功能。学员的努力将得到20，000平方英尺的研究空间和超过2000万美元的年度NIH研究资金的支持。现有资源的组合质量和多样性以及教师先前学员的成功证明，该计划将成功地培训下一代对基础和转化消化科学感兴趣的研究人员。

DESCRIPTION (provided by applicant): The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades. Since its inception in 1989, our original NIDDK-funded training program supported a large number of physician scientists, many of whom now maintain full time academic positions in the U.S. The original grant, which was designed mainly to train physician scientists was until recently continuously funded for 20 years. We now have developed a new program that focuses solely on training postdoctoral (MD, PhD, MD/PhD) and predoctoral PhD candidate scientists interested in basic and translational digestive sciences. In addition to seven astroenterologist physician scientists (Owyang, Merchant, Wiley, Kao, Todisco, Zimmermann, Wang, all R01 holders), we have expanded our research base to include an additional nine R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (Omary, Rui, Samuelson, Shah, Williams), Department of Pathology (Nunez), Department of Cell and Developmental Biology (Gumucio), Division of Infectious Diseases (Young) and Division of Metabolism, Endocrinology, & Diabetes (Myers). This program consolidates the major investigators who are conducting gastrointestinal research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in basic and translational digestive sciences. Our group of 16 program faculty are all members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986, and bring a long history of collaboration and team science. The training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) neurobiology of peptide control, visceral pain and neurosignaling regulating GI motility; 2) molecular and cellular mechanisms of inflammation, tissue injury and repair; 3) cell growth, differentiation and programmed cell death. Support is requested for 4 predoctoral trainees seeking PhDs in one of eight disciplines that range from Physiology to Cell and Molecular Biology and for 4 postdoctoral trainees. The program will be co-directed by Chung Owyang , MD (Chief of the Division of Gastroenterology) and Bishr Omary, MD, PhD (Chair of Physiology) and includes unique coursework, seminars, strong mentoring and other enriching features. The efforts of the trainees will be supported by 20,000 ft2 of research space and more than $20 million of annual NIH research funding. The combined mass and diversity of available resources and the demonstrated successes of the faculty's prior trainees provide tangible evidence that this program will be successful in training the next generation of investigators interested in basi and translational digestive sciences.