Training in Basic and Translational Digestive Sciences

描述(由申请人提供)：在过去的几十年里，密歇根大学在胃肠科学方面有着卓越的培训历史。自开始以来，我们最初的NIDDK资助的培训项目支持了大量的内科科学家，其中许多人现在美国拥有全职学术职位。最初的拨款主要用于培训内科科学家，直到最近才连续资助了20年。我们现在已经开发了一个新的项目，只专注于培养对基础消化科学和翻译消化科学感兴趣的博士后(MD、PhD、MD/PhD)和博士后候选人科学家。除了7名星肠病内科科学家(OwYang、Merchant、Wiley、Kao、ToDisney o、Zimmermann、Wang，均为R01持有者)外，我们还扩大了研究范围，包括来自分子和综合生理学系(Oary、Rui、Samuelson、Shah、Williams)、病理系(Nunez)、细胞与发育生物学系(Gumucio)、传染病科(Young)以及代谢、内分泌学和糖尿病科(Myers)的9名R01资助的基础和内科科学家。该计划将在密歇根大学医学院进行胃肠道研究的主要研究人员整合为一个强大的核心导师，以培训对基础和翻译感兴趣的内科科学家和生物医学研究人员 消化科学。我们的16名项目教员都是自1986年以来由NIH(P30 DK34933)资助的密歇根消化系统疾病核心中心的成员，并带来了悠久的合作和团队科学的历史。培训计划集中在三个主题领域，为参与培训的教师提供特殊的跨学科合作：1)肽控制、内脏疼痛和调节胃肠道运动的神经信号的神经生物学；2)炎症、组织损伤和修复的分子和细胞机制；3)细胞生长、分化和程序性细胞死亡。请求为4名博士前实习生和4名博士后实习生提供支持，这些博士后受训人员在从生理学到细胞和分子生物学的8个学科中的一个学科中寻求博士学位。该计划将由Chung OwYang医学博士(胃肠病学部主任)和Bishr Oary医学博士(生理学主席)共同指导，包括独特的课程、研讨会、强大的指导和其他丰富的功能。受训者的努力将得到2万平方英尺的研究空间和每年超过2000万美元的NIH研究资金的支持。大量和多样化的可用资源，以及教员先前受训人员取得的成功，提供了切实的证据，表明该项目将在培训对基础和翻译消化科学感兴趣的下一代研究人员方面取得成功。

DESCRIPTION (provided by applicant): The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades. Since its inception in 1989, our original NIDDK-funded training program supported a large number of physician scientists, many of whom now maintain full time academic positions in the U.S. The original grant, which was designed mainly to train physician scientists was until recently continuously funded for 20 years. We now have developed a new program that focuses solely on training postdoctoral (MD, PhD, MD/PhD) and predoctoral PhD candidate scientists interested in basic and translational digestive sciences. In addition to seven astroenterologist physician scientists (Owyang, Merchant, Wiley, Kao, Todisco, Zimmermann, Wang, all R01 holders), we have expanded our research base to include an additional nine R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (Omary, Rui, Samuelson, Shah, Williams), Department of Pathology (Nunez), Department of Cell and Developmental Biology (Gumucio), Division of Infectious Diseases (Young) and Division of Metabolism, Endocrinology, & Diabetes (Myers). This program consolidates the major investigators who are conducting gastrointestinal research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in basic and translational digestive sciences. Our group of 16 program faculty are all members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986, and bring a long history of collaboration and team science. The training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) neurobiology of peptide control, visceral pain and neurosignaling regulating GI motility; 2) molecular and cellular mechanisms of inflammation, tissue injury and repair; 3) cell growth, differentiation and programmed cell death. Support is requested for 4 predoctoral trainees seeking PhDs in one of eight disciplines that range from Physiology to Cell and Molecular Biology and for 4 postdoctoral trainees. The program will be co-directed by Chung Owyang , MD (Chief of the Division of Gastroenterology) and Bishr Omary, MD, PhD (Chair of Physiology) and includes unique coursework, seminars, strong mentoring and other enriching features. The efforts of the trainees will be supported by 20,000 ft2 of research space and more than $20 million of annual NIH research funding. The combined mass and diversity of available resources and the demonstrated successes of the faculty's prior trainees provide tangible evidence that this program will be successful in training the next generation of investigators interested in basi and translational digestive sciences.