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Prospective renal insufficiency cohort evaluation: PRICE

前瞻性肾功能不全队列评估：PRICE

基本信息

批准号：
10207602
负责人：
DEBBIE L COHEN
金额：
$ 68.93万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-28 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10207602
关键词：
Accelerometer Acute Address Adult Albumins Ambulatory Blood Pressure Monitoring Ancillary Study Apple watch Area Bioinformatics Biological Biological Markers Biometry Breathing Cardiovascular Diseases Cardiovascular system Cessation of life Chronic Kidney Failure Chronic Kidney Insufficiency Clinical Cohort Studies Collaborations Communities Complex Creatinine Data Data Coordinating Center Development Devices Disease Progression Documentation Electrocardiogram Enrollment Ensure Evaluation Event Feasibility Studies Fibroblast Growth Factor Funding Goals Grant Health Heart Diseases Heart failure Home Hour Impairment Individual Institution Kidney Kidney Diseases Kidney Failure Learning Letters Manuscripts Measurement Measures Medical Genetics Medical Records Methodology Methods Mission Monitor National Institute of Diabetes and Digestive and Kidney Diseases Older Population Outcome Paper Parents Participant Patient Recruitments Patient Self-Report Pennsylvania Phase Phenotype Philadelphia Physical activity Pilot Projects Population Procedures Productivity Progress Reports Proteins Proteinuria Protocols documentation Publishing Quality Control Questionnaires Renal function Research Research Personnel Resources Risk Risk Factors Role Schedule Science Site Specimen Standardization Technology Universities Urine Variant Writing base clinical center cohort data sharing design experience fitbit follow-up heart rate variability human subject innovation kidney dysfunction longitudinal dataset meetings member new technology novel participant retention phenotypic data programs prospective quality assurance recruit response therapy design

项目摘要

PROJECT SUMMARY The CRIC Study was initiated in 2001 and enrolled its first participants in mid 2003. In the intervening years the CRIC Study has consistently met recruitment goals in Phase 1 and Phase 3, and maintained a high level of participant follow up during the study. We have published over 150 manuscripts and are entering the potential for a fourth phase (2018-2023) of funding during which we hope to follow up the newly recruited participants from Phase 3 (2013-2017; n=1520) and those from Phase 1 (2003-2008; n=3939) who are still active in the study. We propose 12 Specific Aims that are common to each clinical center in this competing U01 renewal application and provide background and methodology to incorporate and number of new measurements into the CRIC Study. In particular, we are adding innovative measures that record 48 hours of heart rate variability, physical activity by accelerometry and breathing rate via the Zephyr BioPatch, and 14 days of continuous ECG monitoring via the ZIO XT Patch. In addition, we plan obtain measures of in-home monitoring for subclinical episodes of AKI using current technologies that allow a fingerstick creatinine measurement and urine protein, albumin and creatinine measures to be obtained at home and uploaded to the CRIC clinical center. In this application we will focus on our Center's productivity in the CRIC study and in particular will showcase the remarkable opportunity available in the understanding of heart failure, the single most common CV endpoint in the CRIC study, through biometric monitoring using these new technologies, along with our site's experience with a pilot study in this area. In this application we will review important aspects of CKD and contributions of our clinical center to the CRIC effort. This application includes a progress report from our site (101) as well as proposals for data sharing and the recruitment of investigators at our Institution as well as outside our Institution to participate in evaluating and publishing findings from this landmark study in the Nephrologic Community that will further the mission of the NIDDK to promote kidney health and to design interventions that mitigate the burden of CKD in the US adult populations with CKD.

项目总结