Prospective renal insufficiency cohort evaluation: PRICE

项目摘要 审评委的研究于2001年启动，并于2003年年中招募了第一批参与者。在此 多年来，审评委的研究始终达到了第一阶段和第三阶段的招募目标， 在研究期间保持高水平的参与者随访。我们已经出版了150多本 手稿，并正在进入第四阶段（2018-2023）的资助，在此期间，我们 希望随访第3阶段（2013-2017; n=1520）新招募的受试者和 1期（2003-2008; n=3939），仍在研究中活跃。 我们提出了12个特定目标，这些目标在本次竞争性U 01更新中对每个临床中心都是通用的 应用程序，并提供背景和方法，以纳入和新的 评估结果纳入审评委的研究。特别是，我们正在增加创新措施， 小时的心率变异性，通过加速度计进行的身体活动和通过Zephyr进行的呼吸率 BioPatch，并通过ZIO XT Patch进行14天的连续ECG监测。此外，我们计划 使用当前技术获得阿基亚临床发作的家庭监测措施， 允许手指针刺肌酸酐测量和尿蛋白、白蛋白和肌酸酐测量， 在家中获得并上传至CRIC临床中心。在本应用程序中，我们将重点介绍 中心在审评委研究中的生产力，特别是将展示 在了解心力衰竭（CRIC中最常见的单一CV终点）方面可用 研究，通过生物监测使用这些新技术，沿着我们的网站的经验 在这一领域进行试点研究。 在本申请中，我们将回顾CKD的重要方面以及我们的临床中心对 审评委的努力。此应用程序包括我们的网站（101）的进度报告以及建议 在我们的研究机构以及我们的研究机构之外进行数据共享和招募研究者 参与评估和发表这项具有里程碑意义的肾病研究的结果， 社区，将进一步NIDDK的使命，以促进肾脏健康和设计 减轻美国CKD成人人群CKD负担的干预措施。

PROJECT SUMMARY The CRIC Study was initiated in 2001 and enrolled its first participants in mid 2003. In the intervening years the CRIC Study has consistently met recruitment goals in Phase 1 and Phase 3, and maintained a high level of participant follow up during the study. We have published over 150 manuscripts and are entering the potential for a fourth phase (2018-2023) of funding during which we hope to follow up the newly recruited participants from Phase 3 (2013-2017; n=1520) and those from Phase 1 (2003-2008; n=3939) who are still active in the study. We propose 12 Specific Aims that are common to each clinical center in this competing U01 renewal application and provide background and methodology to incorporate and number of new measurements into the CRIC Study. In particular, we are adding innovative measures that record 48 hours of heart rate variability, physical activity by accelerometry and breathing rate via the Zephyr BioPatch, and 14 days of continuous ECG monitoring via the ZIO XT Patch. In addition, we plan obtain measures of in-home monitoring for subclinical episodes of AKI using current technologies that allow a fingerstick creatinine measurement and urine protein, albumin and creatinine measures to be obtained at home and uploaded to the CRIC clinical center. In this application we will focus on our Center's productivity in the CRIC study and in particular will showcase the remarkable opportunity available in the understanding of heart failure, the single most common CV endpoint in the CRIC study, through biometric monitoring using these new technologies, along with our site's experience with a pilot study in this area. In this application we will review important aspects of CKD and contributions of our clinical center to the CRIC effort. This application includes a progress report from our site (101) as well as proposals for data sharing and the recruitment of investigators at our Institution as well as outside our Institution to participate in evaluating and publishing findings from this landmark study in the Nephrologic Community that will further the mission of the NIDDK to promote kidney health and to design interventions that mitigate the burden of CKD in the US adult populations with CKD.